Talk:Frontal lobe epilepsy

Edits for 19 April 2006

My main edit for this article was to wikify it and add a few sources (I removed the wikify tag, but I left the cite tag until I or someone else can verify the information with non-web based publications). Also, I did a major rewrite. I mostly extruded on some points the original author only briefly touched upon, but mostly I tried to make it sound more encyclopedic (whcih included the removal of a few occurrences of the phrase "biazrre behavior," which seems subjective and potentially offensive). Other than that, just some minor grammatical fixes.TheTomato 03:57, 20 April 2006 (UTC)

• And I added external links/links to other articles, for cross-references and sources.TheTomato 04:00, 20 April 2006 (UTC)

It doesn't appear that any of the references are primary references; the link to the one that may be a primary reference is not working NeuroJoe (talk) 17:24, 13 November 2009 (UTC)

Your page is still listed as a neuroscience stub. It seems you guys have added enough information to the topic that you could remove this stub status. If you click on the neuroscience stub link at the bottom of your page it will tell you how to remove the stub status --Lildevil3221 (talk) 20:38, 19 November 2009 (UTC)

Comments

You did a good job explaining the symptoms of FLS both on the physical and the underlying neurological levels. An item that may give some added medical significance to the "Frequency" section is the relationship between a high-frequency of seizures and depression. An informative article on the "bidirectional relationship between seizure frequency in epilepsy and depressive symptoms" written by B. Metternich, K. Wagner, A. Brandt, R. Kraemer, F. Buschmann, J. Zentner, and A. Schulze-Bonhage and published in Epilepsy & behavior can be found here. Of course, there is a significant deal of overlap between the topics of depression and temporal lobe seizures in this topic and not too much information should be included here, but some coverage of the item as well as an internal link to the depression article would make your article more complete. CharlesWCII^talk 19:50, 28 November 2009 (UTC)

Thanks. We added some information on the depressant effects in the Education/learning and Cognitive function section, along with a link to the depression page. Lavallco (talk) 10:55, 7 December 2009 (UTC)

Your article is off to a good start; many key points concerning frontal lobe epilepsy have been introduced. Visual aids will help support the information presented in the text. Perhaps an image of the brain with the affected areas labeled or a comparison between healthy and damaged tissue will help your readers better visualize the path of the disease. In the Introduction of the article it is mentioned the FLE is commonly misdiagnosed and sometimes an MRI and EEG are necessary to confirm the diagnosis. It may be beneficial to the article and its readers if the reasons for the misdiagnosis is expressed, the conditions that are incorrectly accredited to the disease symptoms, and the results of the MRI and EEG that lead physicians to the correct diagnosis.KrystalMarquis (talk) 00:03, 29 November 2009 (UTC)

The definitely made the page a lot better, thanks for the idea. We also added a misdiagnosis section, again thanks for the input. Lavallco (talk) 10:55, 7 December 2009 (UTC)

You have written a very informative article. It is very helpful to have the links to other wikipedia articles, especially with the symptoms and medications. In expanding your article, you may want to include topics of future research or trials that could occur to increase the knowledge of frontal lobe epilepsy. Additionally, you may consider adding graphics to assit in your explanation of frontal lobe epilepsy. marissa.hone 29 November 2009 —Preceding undated comment added 17:17, 29 November 2009 (UTC).

Thanks. We added some graphics and tried to find some topics of future research, but were unable to. We did find lots of recent work done, such as the gamma-knife radiosurgery, though, and have included these findings. Lavallco (talk) 10:59, 7 December 2009 (UTC)

Wow, good article. I liked the detail you went into when describing different seizures in different parts of the frontal cortex. It would be interesting to read a more detailed description of the possible genetic causes of frontal lobe epilepsy described briefly in the end of the "Causes" section. As part of either the "Causes" or "Frequency" section, it would be interesting to include information about possible demographic incidences of the disease, if this information is available. In addition, I think it would be helpful to include a more detailed description of the target pathways for the medications used to treat frontal lobe epilepsy. Great article though! Matthew Cedar Warman (talk) 17:38, 29 November 2009 (UTC)

Good advice. We tried to elaborate on the genetics of the disease a little better and also added a section on the pathways of the medications. Lavallco (talk) 11:02, 7 December 2009 (UTC)

I found this article to be extremely informative and organized. I especially respect the detailed manner in which you addressed the various symptoms associated with different parts of the frontal cortex. Job well done! My only suggestion is to perhaps add a section about the psychological and/or social impacts of frontal lobe epilepsy. I tried to dig up some information for you, and it seems that most conclusive research to date deals primarily with temporal lobe epilepsy, not FLE. However, here are a few links to studies that may be helpful to you.

[1] (Neuropsychologic Effects of Frontal Lobe Epilepsy in Children)

[2] (Just the abstract here is free, but it provides some good basic information).

[3] (I found this one to be the most helpful. It discusses both neuropsychological and cognitive effects of FLE.)

Hope this helps! Again, great job!

Haworthk (talk) 19:12, 29 November 2009 (UTC)

Thanks, that is a really interesting topic to include. We added a Social Impacts and Quality of Life section to address it. Lavallco (talk) 11:04, 7 December 2009 (UTC)

Great article. For starters, I would place the introduction in front of the table of contents. Otherwise, it seems like the thing you were lacking the most was sources so I tried to find a couple. [[4]] This article talks about recent developments in MRI and imaging techniques on FLE patients which will allow doctors to operate more frequently on FLE patients. Up until now surgery has not been as effective as it is in TLE but doctors are hopeful that this technique will allow them to offer surgery to those FLE patients that are not helped by medication. Also, perhaps going into more detail about the genetic cause of FLE, autosomal dominant nocturnal frontal lobe epilepsy could be interesting. [[5]] This article, a primary source, goes into detail about the classifications and the genes associated with genetic FLE.Aceintheh0l3 (talk) 23:35, 29 November 2009 (UTC)

Thanks, moving the Intro above the table of contents is definitely easier to read once you get to the page. Also, thanks for the sources they were a big help. Lavallco (talk) 11:04, 7 December 2009 (UTC)

Excellent page. I particularly found the 'Treatments' section informative. I just have a couple suggestions. In the 'Introduction' section, you wrote: "There are a variety of different causes of frontal lobe epilepsy ranging from genetics to head trauma resulting in lesions to the frontal lobes." and in the 'Causes' section you wrote: "The origins of frontal lobe seizures range from tumors to head trauma to genetics." It is not really a big deal but the "head trauma to genetics" stuck out at me in both sections and I think it might help to reword one of the sentences. Also, I know a girl who has epilepsy and because of it, she is not allowed to operate motor vehicles. I think it would help the article to talk about the impacts that having epilepsy might have on someone's life. [[6]] This site might give you some good information on what it is like to have epilepsy. Rickxicity (talk) 20:56, 29 November 2009 (UTC)

Thanks, we incorporated that in the social aspects section. Lavallco (talk) 11:04, 7 December 2009 (UTC)

In the introduction it is stated that frontal lobe epilepsy is characterized by partial seizures (both simple and complex). In the symptoms section, however, it is stated that the types of seizures associated with frontal lobe epilepsy are tonic-clonic seizures(a form of generalized seizures). These conflicting statements need to be rectified. If partial seizures evolving to secondarily generalized seizures is known to occur in frontal lobe epilepsy, this should be mentioned and it will help clarify the conflicting statements regarding partial and generalized seizures.

The claim that “uncontrollable laughing or crying may occur during a seizure” should be cited. Meidenbauer (talk) 02:45, 30 November 2009 (UTC)

Thanks, we cited that statement and tried to clarify the statements regarding seizure types. Lavallco (talk) 11:04, 7 December 2009 (UTC)

Well written, I feel like I understand the subject pretty well after having read it. I was first confused however with the mention of a physical or emotional "aura" that a sufferer might experience. It might be helpful to further explain what these auras entail, or how sufferers experience them. Under symptoms, when you are talking about the medial frontal area, you have a bullet point that says "this is why it is mistaken for a psychological disorder." You could perhaps be a little more specific about why this is true, and perhaps mention one or two psychological disorders that are mistaken for. Also, I'm not sure if there is information on the subject, but if there is, it would be interesting to know the mechanism as to how the genetic mutation mentioned in the article leads to seizures. I noticed also that there was a somewhat significant difference in the age for onset of seizures between the right and left frontal lobes. Is this a negligible difference, or is there a specific reason for the difference? Finally, it might be helpful to explain how focal areas in the frontal lobes are pinpointed before surgery, i.e. is fMRI or some other procedure done for diagnosis. Rueltnj (talk) 02:55, 30 November 2009 (UTC)

Thanks for the input. We tried to correct these problems in the various places that you mentioned them. Lavallco (talk) 11:04, 7 December 2009 (UTC)

Overall, you all did a great job of researching and including thorough and well-written information on FLE. I want to just reinforce many of the comments above, because people made points that I strongly agree with. First of all, a visual aid, even a simple one identifying the frontal lobe of the brain would be a great tool for people to have a tool to visualize where all of these complications stem from (especially for those with no science/neuroscience background). Also, I believe there is a need to expand on what kind of psychological disorders are misdiagnosed when a person may actually have FLE. I feel this is very interesting and also pertinent to the public awareness of this form of epilepsy, when most of what people know about epilepsy is usually temporal lobe epilepsy. In addition, I agree with the need to expound upon how the disorder may affect the lifestyle of the patients that live with it. I know someone with epilepsy and how they must deal with symptoms, etc., however they have temporal lobe epilepsy. How does frontal lobe epilepsy affect patient’s life differently/similarly? I found valuable information and links about living with epilepsy on the Epilepsy Foundation’s website: http://www.epilepsyfoundation.org/living/

It would enhance the article to include a few specifics on living with the condition. On the website there are links to such concerns like: Employment, Transportation, Dating & Marriage, Health & Fitness, Alcohol &Drugs, Insurance, Financial Planning, Safety, and Taking Charge. Even if these are not specifically recognized within the article, this website could be placed under further reading for those interested in learning more.

There is also a mistake in formatting under the heading Causes, when you discuss the main genetic cause for FLE—“Autosomal Dominant Nocturnal Frontal Lobe Epilepsy”, both due to incorrect capitalizations and an incorrect format to link to the corresponding wikipedia article: You can just copy and paste this and you will be all set: Autosomal dominant nocturnal frontal lobe epilepsy Thanks for all the good information! aryberg89 (aryberg89) 23:20, 30 November 2009

Thanks for the help. We tried to address the information you brought up as thoroughly as possible. Lavallco (talk) 11:04, 7 December 2009 (UTC)

This article is pretty informative and well-written. A few areas could be made more specific, mostly regarding the way things actually work. The difference between simple and complex partial seizures could be elaborated. It is stated that surgery, anticonvulsants, and ketone bodies help reduce seizures, but not how or why they work. For example, I would like to know what exactly ketone bodies associate with in the brain that reduce the frequency of seizures. I also know that epilepsy is an illness that has affected many famous people-- it would be interesting to add a section about the social/cultural aspects of epilepsy (Othello, Napoleon, etc.) (alexbodo (talk) 8:13, 30 November 2009 (UTC)

Thanks for the input. We elaborated the difference between simple and complex partial seizures, as well as provided links to their respective pages. We also included pathways for the medications and a social aspect section. Lavallco (talk) 11:13, 7 December 2009 (UTC)

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Orbitofrontal cortex

I believe it to be an erroneous description of orbitofrontal function.

when listing the orbitofrontal cortex, the description is solely based on the deeply flawed somatic marker hypothesis put forward by Damasio. Damasio's entire theory rests upon a very brief description of symptoms from a single patient. he accepted the narrative of this patient completely, biographical details were omitted in his presentation of the case study which he never formally published in a journal but rather presented a rather romanticized account of the patient after a fictionalized account of phineas gage's life.

as the most highly interconnected area of the brain, with many possible impairments possible from dysfunction from the sense of smell to behavioural inhibition and metabolic differences noted in the region across every mental disorder, its function remains a mystery. the wisconsin card sorting test and STROOP test may be sensitive although they are not always sensitive even with complete destruction of the regions.

various completely different hypothesis have been presented from computational branching to the somatic marker hypothesis. but nobody will seriously claim that there is any part of the brain that determines right from wrong. — Preceding unsigned comment added by 49.176.26.249 (talk) 12:31, 4 March 2017 (UTC)

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