Talk:Galanin

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 24 March 2020 and 29 April 2020. Further details are available on the course page. Student editor(s): Wilkinsonre. Peer reviewers: Logan Elkins, H.Bergmann01.

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Some Reference Gaps

Hello,

    I have reviewed this article and cross-referenced the article with the references listed.  Everything stated in the article agrees with the listed references, however I noticed that there were a few statements that need references.  Those statements are the following:

In the Introduction

• "The functional role of galanin remains largely unknown; however, galanin is predominantly involved in the modulation and inhibition of action potentials in neurons."
• "Galanin appears to have neuroprotective activity as its biosynthesis is increased 2-10 fold upon axotomy in the peripheral nervous system as well as when seizure activity occurs in the brain."

In the Tissue Distribution section

• "Within the central nervous system, highest concentrations are found in the hypothalamus, with lower levels in the cortex and brainstem. In the hypothalamus, it is for example found in the ventrolateral preoptic nucleus where it has sleep-promoting function."

In the Structure section

• "In these animal forms, the first 15 amino acids from the N-terminus are identical, but amino acids differ at several positions on the C-terminal end of the protein."
• "For example, porcine and rat galanin inhibit glucose-induced insulin secretion in rats and dogs but have no effect on insulin secretion in humans."
• "The galanin family of protein consists of four proteins, of which GAL was the first to be identified."
• "The other two peptides, galanin-like peptide (GALP) and alarin, were identified relatively recently and are both encoded for in the same gene, the prepro GALP gene."

In the Receptors section

• "Galanin signalling occurs through three classes of receptors, GALR1, GALR2, and GALR3, which are all part of the G protein-coupled receptor (GPCR) superfamily. Galanin receptors are expressed in the central nervous system, in the pancreas, and on solid tumours."

In Clinical Characteristics

Epilepsy Section

• "Galanin in the hippocampus is an inhibitor of glutamate but not of GABA."

Development Section

• "Galanin-mutant animals show a 13% decrease in the number of adult DRG cells as well as a 24% decrease in the percentage of cells expressing substance P. This suggests that the cell loss by apoptosis that usually occurs in the developing DRG is regulated by galanin and that the absence of galanin results in an increase in the number of cells that die."

Wilkinsonre (talk) 01:48, 7 February 2020 (UTC) Nothing on appetite ? could be interesting to add new refs Walidou47 (talk) 02:56, 7 February 2020 (UTC)