Talk:Glucocorticoid receptor
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GR ligands
editWhile the GR/relaxin connection is intriguing, it is not exactly clear what is going on here (see for example http://www.fasebj.org/cgi/reprint/03-1120fjev1). The bell shape GR/relaxin binding curve is very puzzling. Therefore I thought it much safer (especially for article meant for a wide audience) to use dexamethasone instead of relaxin as an example of a GR agonist. Boghog2 18:26, 19 April 2007 (UTC)
Genomic vs. non-genomic effects
editA sentence in the current version of this article reads:
- the [GR] complex activate anti-inflammatory proteins, and repress pro-inflammatory proteins, in the cytosol.
This to me implies a non-genomic effect. Rapid, non-genomic actions of glucocorticoids have been observed and membrane associated GR has been proposed to mediate for these effects. However to the best of my knowledge, this mechanism remains controversial. In contrast transactivation and transrepression mechanisms of GR action (which are both genomics effects) are well established. Hence I believe the above sentence should be modified to read:
- the activated [GR] complex up-regulates the expression of anti-inflammatory proteins [in the nucleus], and represses the expression of pro-inflammatory proteins in the cytosol [by preventing the translocation of other transcription factors from the cytosol into the nucleus].
I realize this wording is more complicated, but I believe it is more accurate. Cheers. Boghog2 (talk) 15:23, 8 March 2009 (UTC)
Review
editEndocrine Rev doi:10.1210/er.2014-1010 (24 pg) JFW | T@lk 05:54, 23 June 2014 (UTC)
Non-parallel structure
editThe GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
I can barely make sense of that, grammatically.
The GR is expressed in almost every cell in the body and regulates genes controlling the developmental, metabolic, and immune responses.
That's now parallel, but is it correct? — MaxEnt 14:01, 22 September 2018 (UTC)
Second solution:
The GR is expressed in almost every cell in the body and regulates genes controlling development, metabolism, and [the?] immune response.