Talk:Glucose 6-phosphatase

Merger proposal

I had a real tough time figuring this out - there are three genes in the glucose 6-phosphatase family of proteins. The genes are G6PC, G6PC2, and G6PC3. They are distinct from each other. What I propose is that G6PC be merged into this article and the article focused more on the G6PC gene product and related diseases, and then links to the articles for the other two genes. But I am open to other suggestions. Gccwang (talk) 03:55, 15 August 2014 (UTC)

If there was a one to one correspondence between enzyme and gene (e.g., only one gene in the human genome that encodes a particular enzyme reaction), then I would support the merger. However in this case we have three genes (G6PC, G6PC2, and G6PC3) that encode enzymes with EC 3.1.3.9 activity. Merging only G6PC into this article does not make sense. Either all four articles should be merge or none. Furthermore including three protein infoboxes in the same article is not practical, hence I believe the four articles should not be merged. I would instead propose to edit the present article to include more information on how the three isozymes differ (e.g., tissue distribution, structure, function, etc.). PMID 23266497 looks like a good review for this purpose. I will try to work on this weekend. Boghog (talk) 05:24, 15 August 2014 (UTC)

Thanks, I agree. Gccwang (talk) 21:27, 16 August 2014 (UTC)

Page edited for clarity and merger proposal withdrawn. Gccwang (talk) 18:17, 21 August 2014 (UTC)