Talk:Gonadotropin-releasing hormone agonist

the most imp section is flare effect and down regulation

it explains the mechanism. we could expand on this section... —Preceding unsigned comment added by 68.61.150.75 (talk) 18:57, 27 December 2009 (UTC)

Control Aging

GnRH treatment represents a potential means of slowing the progress of aging or age-related diseases, the researchers say.

http://news.yahoo.com/brain-region-found-control-aging-191717771.html — Preceding unsigned comment added by 76.176.108.8 (talk) 05:11, 22 January 2014 (UTC)

Proposed deletion of specific drug links from External links section

The specific ones belong on the individual articles (unless any discuss the agents in general) - deleting those 5 would leave just 2. - Rod57 (talk) 16:34, 17 March 2016 (UTC)

External links modified

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Penile atrophy

I heard Dr. William Powers talk about it during his presentations, as well as some anecdotal evidence. But I've been unable to find any other academic sources. Has anyone found any?

Masslan (talk) 18:34, 5 May 2021 (UTC)

Expense

This is bad economics:

GnRH analogues are available as generic medications. Despite this, they continue to be very expensive.

The problem here is that it simply assumes that R&D cost dominates in the case of every medication, and production and distribution are never a primary cost driver.

But quite possibly some drugs are indeed hard to synthesize, or don't have a large usage base to amortize the facilities cost, or are not entirely shelf stable, requiring complex just-in-time manufacture, to pluck a few possibilities out of thin air rather effortlessly.

If there was no cost drop at all between proprietary and generic, then maybe there's some smoke here. — MaxEnt 03:38, 2 November 2021 (UTC)

Rationale for puberty blockers

@Snokalok Taylor et al (2024) says:

Rationales for puberty suppression in the Dutch treatment protocol, which has informed practice internationally, were to alleviate worsening gender dysphoria, allow time for gender exploration, and pause development of secondary sex characteristics to make passing in the desired gender role easier. Practice guidelines propose other indications for puberty suppression, including allowing time and/or capacity for decision-making about masculinising or feminising hormone interventions, and improving quality of life.

This is a recent systematic review and it states that there are multiple reasons for blockers, beyond the straightforward "time to think", and cites the originating Dutch Protocol in support. This is not a new perspective - it is the original perspective, restated in a recent, high quality MEDRS.

This is a complex and highly controversial area with disagreement between MEDRS. I don't think an unsourced claim in wikivoice that it is simply about "pending treatment decisions" does justice to this, and I would suggest keeping references here as blandly factual and neutral as possible and confining the disagreement between MEDRS to the main page. Void if removed (talk) 20:21, 3 May 2024 (UTC)

Then how bout "for a variety of reasons". Saying nothing at all risks them being confused with testosterone blockers like cyproacetate Snokalok (talk) 11:17, 4 May 2024 (UTC)

How about "to delay development of secondary sex characteristics"? I think all reasons agree that's why, but leaves out the more varied why of the why of it (improve mental health/time to think/better "passing" in adulthood). Void if removed (talk) 12:44, 4 May 2024 (UTC)

Reasonable, I'll take that deal. Snokalok (talk) 13:41, 4 May 2024 (UTC)