Talk:Hepatocyte
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Untitled
editIsolated hepatocytes represent one of the most useful in vitro experimental systems for drug discovery and development. As the liver is the major organ for drug metabolism and often a target of drug toxicity, isolated hepatocytes can be used for the evaluation of metabolic stability, metabolite identification, pharmacokinetic drug-drug interactions, and drug toxicity. Our laboratory (Li, AP et al) has over 25 years of experience in hepatocyte isolation, culturing and cryopreservation. Our most recent accomplishment is the cryopreservation of human hepatocytes to retain high viability (routinely over 90% based on trypan blue exclucion) and attachment efficiency (over 50% of our cryopreserved lots can attach and form confluent monolayer cultures after thawing). We are now working to extend this cryopreservation technique to animal hepatocytes (we will start with rat hepatocytes). I would like to welcome discussion on isolated hepatocytes from the public, especially on new science, techniques and applications.Lialbertpakhung 11:59, 24 February 2007 (UTC)
Size of a hepatocyte
editAn IP editor was caught by the edit filter when trying to ask this question, so I am adding it on their behalf: How big (in nm) is a hepatocyte? The article doesn't say... perhaps it should? 28bytes (talk) 14:33, 5 April 2011 (UTC)
Size of a hepatocyte (continued)
editMy number sense was triggered by the figures in this section. A cube with volume of 3.4 x 10-9 cm3 would have a side of about 13 μm (not 20-30). Conversely, a cube of side between 20 and 30 μm would have volume between 8 and 27 x 10-9 cm3, not 3.4. Does the reference provide both of these figures? The discrepancy might be explained if the hepatocyte is not a strict cube, but maybe has projections like a shark's egg case. Alternatively, the cell may have a thick wall, and the figure given is for interior volume. Neither of these ideas is supported by an image search for “hepatocyte”. Mathyeti (talk) 03:47, 14 September 2017 (UTC)
Text removal
editI've removed the following text, introduced by a user with COI and thought to point to the work of scientists employed by the compan, Cellectis, employing the user. See Wikipedia:Conflict_of_interest/Noticeboard#Cellectis. Please feel free to re-insert if in your judgement the article needs the removed information, and the references are appropriate. thanks. --Tagishsimon (talk) 02:23, 20 March 2016 (UTC)
- Hepatocytes can also be derived from pluripotent stem cells; the use of stem cell-derived hepatocytes has shown some promise as a model for drug-induced liver toxicity, but further research is required[1][2].
References
- ^ Sartipy, Peter; Björquist, Petter (2011-05-01). "Concise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment". Stem Cells (Dayton, Ohio). 29 (5): 744–748. doi:10.1002/stem.631. ISSN 1549-4918. PMID 21433222.
- ^ Mandenius, Carl-Fredrik; Andersson, Tommy B.; Alves, Paula M.; Batzl-Hartmann, Christine; Björquist, Petter; Carrondo, Manuel J. T.; Chesne, Christophe; Coecke, Sandra; Edsbagge, Josefina (2011-05-01). "Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project". Alternatives to laboratory animals: ATLA. 39 (2): 147–171. ISSN 0261-1929. PMID 21639679.