Talk:Hexosaminidase

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We researched an enzyme (specifically Hexosaminidase A) for our chemistry class. All of our research is centered on HEXA, but we were directed to the general Hexosaminidase page when we tried to find Hexosaminidase A. As a result, we have now copied our information onto the HEXA page in hopes that this will clear up some of the confusion. We had previously deleted some of your additions because they did not pertain to Hexosaminidase A, but we have stopped editing the Hexosaminidase page. Please allow us to present our information on the HEXA page.

Thanks, Sarah and Cody

This message was sent to HappyInGeneral: I have been working on a Wikipedia project on an enzyme Hexosaminidase A which is an isozyme of Beta-Hexosaminidase, but you just reported my partner (SarahBarker) and I for vandalism. Originally, we were trying to update the Hexosaminidase (as a search for Hexosaminidase A directs you to Hexosaminidase), but after you and Boghog2 made changes to the last "good version." We decided to update the HexA site with all the information on the Hexosaminidase page which was information that we carefully researched, but it is now misinformative information because of the way the Hexosaminidase site is formatted. I'm just curious why you reported us for vandalism or why you keep reverting all the changes we make? We needed to research an enzyme for our end of the semester chemistry project, but we can't even publish our work online because of you. Im really confused? I wouldn't have a problem if you made minor changes, but accusing us of vandalism? Deleting all of our work? Thats ridiculous - especially when the whole page of information and figures on the Hexosaminidase site was added after a lot of careful research. I'd really appreciate it if we could just update a page for at least a few days, so then our professor could atleast accurately grade our project. Sarahebarker (talk) 03:34, 11 December 2009 (UTC)Codyshafer_2011

"Please allow us to present our information on the HEXA page." No problem, but please try to integrate your contributions with existing content rather than overwriting previous content. For example, the {{PBB}} template is much more appropriate for the HEXA page than the {{Enzyme}} template. I have restored the original {{PBB}} template. Please don't change it back. In addition, I have restored the original lead paragraph which provides a good introduction. Finally I have reformatted the references. I intend to further edit the article when I have time to fix the section headings and wiki links. Boghog (talk) 10:09, 11 December 2009 (UTC)

After further reflection, I think the material that you added is more appropriate for the hexosaminidase instead of the HEXA article since your figures refer to both HEXA and HEXB. You claim that "it is now misinformative information because of the way the Hexosaminidase site is formatted". What part of the current version is "misinformative"? Please state your concerns on the article's talk page. I am certain that we can work our a mutually agreeable compromise. Boghog (talk) 18:32, 11 December 2009 (UTC)

Our figures do not represent HEXB, which is where you are misinformed. HEXA is a heterodimer, so it has an alpha and a beta active site. Therefore both of those figures correspond to HEXA. Aside from the first paragraph on Hexosaminidase, the rest of the article pertains to HEXA, which would be confusing to the common Wikipedia user. The function, mechanism of action, and gene mutation subheadings all refer to Hexosaminidase A. There is no reference to HEXB or HEXD at all throughout the article besides in the first paragraph. Therefore, it could easily be proven that the information is better-fitted for an article on Hexosaminidase A. Cheers!

Clarification

OK. Now I clearly understand what the confusion is about. HEXA is a gene that encodes the alpha subunit while HEXB is a gene that encodes the beta subunit. In other words, HEXA ≠ β-hexosaminidase A. Rather the β-hexosaminidase A isozyme is a heterodimer composed of subunits encoded by the HEXA and HEXB genes while β-hexosaminidase B is a homodimer of beta subunits encoded by the HEXB gene. Since the material that you are adding is about the β-hexosaminidase A isozyme, this material is much more appropriate for the hexosaminidase article which contains information about both subunits that comprise the α/β heterodimer while the HEXA article only contains information about the alpha subunit (and by extension only the α/α homodimeric isozyme "S"). Boghog (talk) 20:51, 11 December 2009 (UTC)

One additional note: The confusion arises from the HUGO gene names. Much clearer are the UniProt protein names:

subunit	HUGO gene name	UniProt protein name
alpha	hexosaminidase A (alpha polypeptide)	Beta-hexosaminidase subunit alpha
beta	hexosaminidase B (beta polypeptide)	Beta-hexosaminidase subunit beta

Boghog (talk) 21:18, 11 December 2009 (UTC)

Accordingly, I have replaced the HUGO gene names with UniProt protein names in the protein templates in this article to remove the confusion between hexosaminidase isozyme and gene names. Boghog (talk) 21:39, 11 December 2009 (UTC)

What do we need all synonyms for?

Starting the article with a seemingly endless list of synonyms is a bad start. Use the most common one (move the others down into the article), explain the function, explain the importance. That would be a great start to this article.