Talk:Homology directed repair

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Please add info on "Use in gene editing"

Latest comment: 2 years ago1 comment1 person in discussion

See Talk:CRISPR gene editing#Please add info on non-viral delivery methods & homology-directed repair.

I think there probably should be info on "Use in gene editing" in this article.

For example, it could include some info on this study or its broader type of usage, included in 2022 in science (25 August) like so:

Researchers report the development of a highly effective CRISPR-Cas9 genome editing method without expensive viral vectors, enabling e.g. novel anti-cancer CAR-T cell therapies.^[1]^[2]

Looks like the first reference in this article is about the use in gene editing too, but the article doesn't even mention it.

References

^ Williams, Sarah. "A cellular engineering breakthrough: High-yield CRISPR without viral vectors". Gladstone Institutes. Retrieved 15 September 2022.
^ Shy, Brian R.; Vykunta, Vivasvan S.; Ha, Alvin; Talbot, Alexis; Roth, Theodore L.; Nguyen, David N.; Pfeifer, Wolfgang G.; Chen, Yan Yi; Blaeschke, Franziska; Shifrut, Eric; Vedova, Shane; Mamedov, Murad R.; Chung, Jing-Yi Jing; Li, Hong; Yu, Ruby; Wu, David; Wolf, Jeffrey; Martin, Thomas G.; Castro, Carlos E.; Ye, Lumeng; Esensten, Jonathan H.; Eyquem, Justin; Marson, Alexander (25 August 2022). "High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails". Nature Biotechnology: 1–11. doi:10.1038/s41587-022-01418-8. ISSN 1546-1696. PMID 36008610. S2CID 251843150.

Prototyperspective (talk) 11:47, 8 November 2022 (UTC)Reply

Add topic

[1] Williams, Sarah. "A cellular engineering breakthrough: High-yield CRISPR without viral vectors". Gladstone Institutes. Retrieved 15 September 2022.

[2] Shy, Brian R.; Vykunta, Vivasvan S.; Ha, Alvin; Talbot, Alexis; Roth, Theodore L.; Nguyen, David N.; Pfeifer, Wolfgang G.; Chen, Yan Yi; Blaeschke, Franziska; Shifrut, Eric; Vedova, Shane; Mamedov, Murad R.; Chung, Jing-Yi Jing; Li, Hong; Yu, Ruby; Wu, David; Wolf, Jeffrey; Martin, Thomas G.; Castro, Carlos E.; Ye, Lumeng; Esensten, Jonathan H.; Eyquem, Justin; Marson, Alexander (25 August 2022). "High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails". Nature Biotechnology: 1–11. doi:10.1038/s41587-022-01418-8. ISSN 1546-1696. PMID 36008610. S2CID 251843150.

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