Talk:ISRIB

Study observes that ISRIB reverses age-related mental decline

This is about a primary source that, as such, does not meet WP:MEDRS & is thus not usable in this article.

Please be on the watch for review articles (especially systematic reviews) published in reputable medical journal (from WP:MEDRS) that discuss this article.

• Weiler, Nicholas (2020-12-01). "Drug Reverses Age-Related Mental Decline Within Days". Drug Reverses Age-Related Mental Decline Within Days | UC San Francisco. Retrieved 2020-12-07. (an areticle about the primary source)
• Krukowski, Karen; Nolan, Amber; Frias, Elma S; Boone, Morgane; Ureta, Gonzalo; Grue, Katherine; Paladini, Maria-Serena; Elizarraras, Edward; Delgado, Luz; Bernales, Sebastian; Walter, Peter; Rosi, Susanna (2020-12-01). "Small molecule cognitive enhancer reverses age-related memory decline in mice". eLife. 9. eLife Sciences Publications, Ltd. doi:10.7554/elife.62048. ISSN 2050-084X.{{cite journal}}: CS1 maint: unflagged free DOI (link) (the primary source itself)

The eLife article states that it is a selective, not for profit peer-reviewed open access scientific journal for the biomedical and life sciences. Peaceray (talk) 23:48, 7 December 2020 (UTC)

@Peaceray This article never mentions efficacy is in rodents only. 2603:6000:D700:194D:B9AA:2612:8AE3:60A2 (talk) 17:55, 31 January 2023 (UTC)

I beg to differ. When one reads the first citation, its second heading is Rapid Rejuvenation of Mental Faculties in Aged Mice Implicates Reversible Physiological ‘Blockage’ Behind Age-Related Cognitive Losses & the second citation mentions mice in the title. Peaceray (talk) 18:06, 31 January 2023 (UTC)

JSmol link seems to be broken

I get:

ERROR opening https://cactus.nci.nih.gov/chemical/structure/O%3DC%28COC1%3DCC%3DC%28Cl%29C%3DC1%29N%5BC%40%40H%5D2CC%5BC%40%40H%5D%28NC%28COC3%3DCC%3DC%28Cl%29C%3DC3%29%3DO%29CC2/file?format=sdf&get3d=True -- O%3DC%28COC1%3DCC%3DC%28Cl%29C%3DC1%29N%5BC%40%40H%5D2CC%5BC%40%40H%5D%28NC%28COC3%3DCC%3DC%28Cl%29C%3DC3%29%3DO%29CC2 could not be loaded.

Is this temporary? If not, is it wide spread to other molecules? — Preceding unsigned comment added by 27.32.95.28 (talk) 08:52, 13 December 2020 (UTC)

There's no link to cactus.nci.nih.gov on the generated page, and that link also seems to work now. I'm not sure what was broken, but it looks to be fixed now. grendel|khan 18:28, 9 February 2021 (UTC)

Rewording required.

Cognitive improvements are in murine(rat and mouse) studies only. Absolutely No Human Studies (should be in bold letters) before any claims of efficacy. 2603:6000:D70A:BC00:CD7B:5C6:9C43:B886 (talk) 17:09, 28 May 2022 (UTC)