Talk:Imidazenil
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The claim that imidazenil doesn't produce tolerance/dependence could be misleading
editIn the past it has been claimed a lot about new drugs that they don't produce tolerance or dependence. As far as I know, in practically all cases it turned out to be false after more rigorous trials and experiments. As far as I'm aware, there is no solid reason why a partial agonist wouldn't produce both tolerance and dependence in the long-term. It is true that partial agonists generally tend to do so slower and weaker than full agonists, but they do nonetheless produce noticeable levels of both.
I haven't time to fully examine both papers used as refs, but even looking at the title of the second ([6]) one, the title of the paper says "imidazenil...exhibits low tolerance and dependence liabilities in the rat". Key word being "low" instead of "no/lack of". Also, both experiments were performed on rodents, not human trials. So it would be too hasty to claim that it produces no tolerance and dependence (such wording implying it also applies to humans), and there needs to be more careful wording. Something along the lines of "in experiments on rodents, chronic imidazenil administration seems to produce little to no tolerance or dependence".
Since I'm a newbie contributor to Wikipedia, I haven't yet edited the page and I'm waiting for others' input. — Preceding unsigned comment added by HydroxyPCP (talk • contribs) 21:08, 23 November 2017 (UTC)
- In general, articles on medical topics should be based on references that satisfy criteria outlined in Wikipedia:Identifying reliable sources (medicine). In this case, the content was based only on studies performed in animals and it is unknown whether these effects occur in humans as well. Therefore, I have simply removed the content. -- Ed (Edgar181) 13:58, 24 November 2017 (UTC)