Talk:Immunoglobulin E

Very long run-on sentence

Beginning with "Although IgE is typically the ..." This whole paragraph is a single sentence packed with a broad variety of punctuation. As a reader who is not formally skilled in Immunology, it makes comprehension between difficult and onward to impossible.

Cleanup

Someone has greatly expanded the article, but it is now almost exclusively about allergy. Scientific articles in this field should really follow the form (1) Physiology (normal function), (2) Genetics/molecular biology (ultrastructure and DNA), (3) Role in disease (allergy, in this case), (4) Therapeutic role (e.g. cromoglycate or omalizumab).

In its present form, the article is off-balance. Could the new contributor kindly do some tidying up and avoid speculation as much as possible? JFW | T@lk 21:26, 8 October 2005 (UTC)

I've tried to reword it so the article is more centred on IgE rather than drifting into slightly irrelevent stuff. Obviously IgE and allergy are intimately connected topics, but hopefully this is an acceptable improvement?

AIT

The article continues to contain highly biased and incomplete information. Unfortunately I have only the knowledge to recognize this, and do not feel I have the knowledge to correct it. I suggest the reader take this article with a grain of salt and consider alternate sources such as MedLine.

LNB

The "Allergy Misconceptions" segment is highly subjective and suspicious of personal agenda. It should be designated as such by a moderator or, preferably, removed completely as it has nothing to do with IgE.

GPG, NREMT-P

^ Yes I just removed it a few minute ago. People are confusing mild immune responses to foods (IgG or not) with truly allergic life-threatening illness mediated by IgE. Anonywiki 23:20, 5 August 2007 (UTC)

[LKP:] Someone got the history of the discovery of IgE wrong, the author seemingly confused Norman's and Lichtenstein's work on AgE (antigen E from ragweed, an allergen component) with IgE, the immunoglobulin identified during the same period: I posted this correction which was removed after 4 minutes. Please read the suggested literature ( Allergol Int. 2013 Mar;62(1):3-12. doi: 10.2332/allergolint.13-RAI-0537.Mast cells and IgE: from history to today. Saito H1, Ishizaka T, Ishizaka K. ) and the original references and the mistake should be clear to all:

IgE was simultaneously discovered in 1966-7 by two groups: Dr.s Kimishige and Teruko Ishizaka and Dr. Margaret M. Hornbrook in the Children's Asthma Research Institute and Hospital in Denver, CO. and by Gunnar Johansson and Hans Bennich in Uppsala, Sweden — Preceding unsigned comment added by 213.83.135.20 (talk) 06:26, 24 February 2016

So my correction was live 4 minutes before (Personal attack removed) removed it. Now 2 days have passed. Have you had time to read the documentation, and will you take responsibility to leave the former version on the page? Or can we start moving towards what really happened with IgE? Otherwise, please see http://www.eaaci.org/resources/scientific-output/global-atlas-of-allergy.html and find chapter 2, where Johansson tells more or less the same story as Ishizaka. This what is generally believed in the allergy community. — Preceding unsigned comment added by 80.198.37.130 (talk) 22:28, 25 February 2016 (UTC)

In case you continue to have reading comprehension issues, my username is "the wolf child" (de ulven barn). I see you reverted your edit back in again, but that's not how Wikipedia works. (see WP:BRD) The reason you take your issue to the talk page is so that is can be discussed with other contributors. If a consensus is reached supporting your edit, then you can re-add it. You can't just simply re-write your edit summary here, insult another editor then cram your edit back in. The content you are trying to change is properly supported by a reliable source. If you don't achieve consensus here, (or don't want to wait), you can challenge the attached sources at the WP:RSN. Please read Wikipedia's editing policies and guidelines, especially WP:EW, so that you can learn to contribute more effectively. - ^theWOLFchild 23:24, 25 February 2016 (UTC)

Hello. The changes made by the IP user are correct, according to his references cited and this additional [and powerful] Review article: The discovery of IgE, Stanworth DR. Allergy 1993: 48: 67-71]. The literature is in agreement in that the two teams that independently discovered IgE were: Johansson & Bennich (mostly), and Ishizaka's team. And it is evident that Lichtenstein and Norman made a subsequesnt discovery on myeloma using the already discovered IgE. Cheers, BatteryIncluded (talk) 04:50, 26 February 2016 (UTC)

@BatteryIncluded: - So with the current version, the source attached does not support the content? Or is the source itself not RS? - ^theWOLFchild 23:36, 26 February 2016 (UTC)

The source quoting Lichtenstein and Norman is not about the IgE discovery, but a type of myeloma. All sources indicate 2 teams: Johansson & Bennich and Ishizaka's team. I took the liberty to edit the portion on the discovery. Cheers, BatteryIncluded (talk) 01:48, 27 February 2016 (UTC)

Thanks for that. I'm glad it got sorted out. Cheers - ^theWOLFchild 02:06, 27 February 2016 (UTC)

[LKP] Thanks, @BatteryIncluded:, the text here is now correct. However, the link to Gunnar Johansson is not. Now two different Johanssons have been merged into a single person. The original article describes a psychologist who died 1998. The immunologist Gunnar Johansson (in the scientific society and literature mostly known as SGO Johansson) is alive and well, and I am sure he will be sorry to read about his death. He still serves as a kind of professor emeritus at the Karolinska Insituttet in Stockholm, Sweden. http://ki.se/en/people/sgojoh I checked the Swedish Wiki, and he is recognized as a person that needs an article, but it has not yet been written. I'm obviously not well aquainted with the Wiki etiquette, I just happen to have known and worked with the persons that have been discussed. — Preceding unsigned comment added by 80.198.37.130 (talk) 12:19, 27 February 2016

In that case it's probably best to confine your comments and suggestions to the related talk pages as you may have a conflict of interest. - ^theWOLFchild 19:01, 27 February 2016 (UTC)

Thewolfchild is correct; it is best you continue your valuable feedback in these talk pages and not edit the articles. I am currently busy with real life but I will make the point of separating both biographies on Gunnar Johansson. I thank you both for working together with me. Cheers, BatteryIncluded (talk) 19:36, 27 February 2016 (UTC)

I made a new article on him: Gunnar Johansson (biochemist). Please feel free to give feedback at THAT talk page. Thank you. BatteryIncluded (talk) 16:10, 29 February 2016 (UTC)

References

Request for rewriting run-on sentence

Can someone, not necessarily an expert, please rewrite this run on sentence;
"IgE that can specifically recognise an "allergen" (typically this is a protein, such as dust mite DerP1, cat FelD1, grass or ragweed pollen, etc.) has a unique long-lived interaction with its high-affinity receptor FcεRI so that basophils and mast cells, capable of mediating inflammatory reactions, become "primed", ready to release chemicals like histamine, leukotrienes, and certain interleukins, which cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis, and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis."
Thanks very much 220.101.92.34 (talk). —Preceding undated comment added 07:50, 11 May 2011 (UTC).

What's the normal adult and/or children's level of IgE?

i added a citation needed label to the value that's already in the article.

i spent a long time googling and haven't found any quotes of "normal" levels (neither with nor without a description of how many standard deviations "normal" actually means!).

If somebody can find this, then we could add one or both of the following refs and also give the value in IU/mL (or kIU/L, which is the same thing). The conversion according to these two references is: 1 IU/mL = 1kIU/L = 2.44 ng/mL. The polish reference gives 2.44, the US one 2.4, so presumably the polish one just goes to higher precision and the US one is a rougher approximation.

• http://www.mp.pl/artykuly/index.php?aid=24925
• http://www.aruplab.com/guides/ug/tests/0050345.jsp

These would put 75 ng/mL = 30.7 kIU/L or 31 kIU/L to keep about the same level of precision.

However, until we get a reference, i don't see much point in adding the kIU/L value.

Boud (talk) 19:32, 7 August 2008 (UTC)

Irrelevant/unexplained?

This hardly seems relevant - when its there with out further introduction?

"In 1975, Robert N. Hamburger, M.D. published "Peptide Inhibition of the P-K Reaction" based on blocking up to 89% of the IgE receptors on mast cells by the pentapeptide representing amino acids 320 to 324 on the epsilon chain of IgE.[13] Confirming the IgE binding site, in 1979 he published in Immunology "Inhibition of IgE binding to tissue culture cells and leucocytes by pentapeptide" (ref).

I'll remove unless someone objects? — Preceding unsigned comment added by Radicularia (talk • contribs) 21:25, 4 March 2012 (UTC)

Needs to be comprehensible to the intelligent layman

This article is full of technical terms, explained only by links to other pages, which themselves are full of other technical terms. This page may (?) be well written for biologists and doctors. Someone please make it accessible by the average parent who is looking up information for their hyperallergic children. I do *NOT* mean to "dum it down". Make it as comprehensive as possible. Just leave some of it within reach of non-experts. 69.247.14.176 17:17, 5 February 2015 (UTC)

Came here to say exactly the same thing. Take the third sentence of the article as an example: "Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4)."Faff296 (talk) 06:52, 11 September 2017 (UTC)

Is spelling dumb as 'dum' an example of dumbing down?Andrew ranfurly (talk) 07:54, 18 May 2018 (UTC)

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Explanation of where / how IgEs are produced?

I don't see in the article any meaningful explanation of the production of IgEs. There's a graphic and a few allusions to the fact that they are specific to specific antigens, and I'd be curious to have more information about how that comes to be. Unfortunately I don't have the knowledge to add this myself, but if someone else would be able to add it would be appreciated! zplizzi (talk) 16:30, 14 September 2022 (UTC)