Talk:Immunoglobulin superfamily

Structure pic does not show an IgSF domain

I just noticed that the nice structure picture of the single immunoglobulin domain is actually a fibronectin domain from tenascin. Although technically it has the same beta sandwich structure it does not belong to the immunoglobulin superfamily.Alexbateman (talk) 15:52, 20 January 2009 (UTC)

Thanks for the heads-up Alex, although the fibronectin type III domain is Ig-like, I have changed image to an antibody fragment to avoid confusion. Best Wishes, ~ Ciar ~ _{(Talk to me!)} 05:20, 21 January 2009 (UTC)

Comment on introduction

In the introduction it mentions that Ig domains are cell surface or soluble. While this is largely true there are a few rare cases of intracellular Ig domains such as in the giant muscle protein titin. I'm not sure that this really needs explicitly mentioning in the introduction. But a slight reword could be useful.Alexbateman (talk) 11:41, 12 June 2009 (UTC)

Leukocyte immunoglobulin-like receptors

Article makes no mention of the LIR family of receptors (e.g. LILRB4, LILRA4, etc.). SteveChervitzTrutane (talk) 23:28, 22 November 2010 (UTC)

Hi Steve,

Thanks for the comment. I don't think the article about the Ig superfamily should be comprehensive. There are literally thousands of example proteins to choose from. However, if there was some aspect of the LIR family biology that was illustrative of the superfamily then they might be worth a mention. Any thoughts on that or other ways to improve this article? Alexbateman (talk) 10:45, 23 November 2010 (UTC)

Hi Alex -- Why not strive for comprehensiveness? (This is an encyclopedia after all :-). Actually, I don't think we need to document each protein here, but the LIL's are a sizable subfamily that seem worth mentioning. Perhaps we could point to a separate article (which doesn't yet exist) that covers the LIL subfamily and reference that from here? The killer cell immunoglobulin receptors might also fit into this subfamily since they are located in the same gene cluster as the LIL's on 19q (e.g. KIR3DL1). (Note: I'm not an expert on these receptors.) SteveChervitzTrutane (talk) 19:58, 2 December 2010 (UTC)

A page for the LIL subfamily has since been created (thanks Arcadian!). I created a category for the Ig-like receptors and placed the existing sub-pages into it (LIL's and KIR's). Also added a new row in the table in this article for the LIL's. SteveChervitzTrutane (talk) 08:19, 4 December 2010 (UTC)