Talk:Inositol/Archive 1

Energy drinks

"It is used as a component of energy drinks. However, several studies show that it has no effect at all."

Reference links? I do not belive in this statement! —Preceding unsigned comment added by 212.37.99.138 (talk • contribs) 08:40, 30 September 2005 I have seen that inositol can have a calming effect on a person. It is transformed to gaba in the brain which is a inhibitor neuro tansmitter. Why they put it in energy drinks I could not say - maybe to counter or calm the energy effect. Reference : The "Edge Effect" by Dr. Eric Braverman. GABA is copied by alcohol and valium. —Preceding unsigned comment added by 68.116.237.77 (talk • contribs) 18:04, 4 December 2005

The cited book doesn't even care to cite the literature, as far as I can see on Google Books. This book is certainly not a reliable source. (The statement about energy drinks currently isn't in the article, and I think it's better that way. For any claims, provide reliable sources). Icek 21:11, 5 July 2007 (UTC)

Inositol decreases iron absorption

Some studies show that inositol phosphates are responsible for lessening the amount of iron that the body can absorb, so use with caution. Unfortunately I have no way of verifying this, no references; please post some if you have access to relevant studies. If this is true, it may be best if inositol is not taken daily but only three times a week for example, and taken with the afternoon snack or a light dinner.

I wonder if a standard issue blurb should be added to articles on chemicals, drugs and alternative remedies about how this information is not to be considered medical advice. Even articles written by doctors can not take in to account every person's possible reactions, side effects and complications from other medications. Apple Rancher 02:22, 23 September 2006 (UTC)

Phytate, not inositol, decreases iron absorption, and mineral absorption in general. — Preceding unsigned comment added by 96.239.87.245 (talk) 23:47, 11 August 2016 (UTC)

Why take inositol in the first place, when the body can easily synthesize it from glucose? -- Boris 13:32, 28 December 2005 (UTC)

It is concevible that the body is not synthesizing enough of it (a key theme in biochemistry is conscentrations and management of balances between chemicals). Many disorders result from some chemical either not being produced at optimal levels or not being recognized like insulin. If inositol is as said needed for

1. controlling intracellular calcium ion (Ca++) concentration
2. maintaining membrane potential of the cell.
3. enhancing the activity of serotonin

It could easily be a potential target for treating neurological conditions. Apple Rancher 02:06, 23 September 2006 (UTC)

Is inositol supposed to taste somewhat like powdered sugar?

Showjumpersam 21:31, 17 February 2007 (UTC) You don't really need a reference, other than an understanding of basic inorganic chemistry -- polyols like the inositols are know to chelate to metal ions like Fe++, making them less soluble.

Inositol may taste sweet - it is a fairly similar structure to simple saccharides and though I work with it I can't say I've tucked in. A number of things taste sweet though -- I've breathed in chlorinated solvents (by accident, and only very briefly) and they are sweet tasting.

The references

Both references pointed, although not directly, to the same research material. -- Boris 18:57, 3 February 2006 (UTC)

Picture

There should be hydroxyl groups instead of single oxygens substituted on that ring. (there is an hex-OL in the end of the IUPAC name too) Can someone correct that? - I don' know how. -- 80.171.18.224 07:59, 24 March 2006 (UTC)

Certain variants of Inositol ameliorate Alzheimer's-like disease in mice, according to a new study by Canadian researchers. http://www.medicalnewstoday.com/medicalnews.php?newsid=45078&nfid=nl 68.227.227.29 20:28, 19 June 2006 (UTC)

Why isn't the picture in the (more obvious) chair configuration? --moof 17:25, 12 September 2006 (UTC)

I've added new images. I hope this helps. --Ed (Edgar181) 19:24, 26 September 2006 (UTC)

My concern isn't with the contents of the picture but rather its location. Could the Synthesis and Function sections be reversed, or the picture edited to make a block that doesn't cover part of the sidebar with the graphic image? If the graphic is accurate I can perform the conversion, but I have some concern of its accuracy because of the comments above. --rj 05:10, 1 May 2008 (UTC)

Misplaced references

Strangely enough, there were a large number of references in the middle of the article. Specially, they were under the Synthesis section and were in plain text. I'm now moving them here below. --AB (talk) 02:08, 27 July 2008 (UTC)

---

1: Eisenberg F Jr, Parthasarathy R. Measurement of biosynthesis of myo-inositol from glucose 6-phosphate. Methods Enzymol. 1987;141:127-43. No abstract available. PMID: 3600356 [PubMed - indexed for MEDLINE]

2: Parthasarathy R, Eisenberg F Jr. The inositol phospholipids: a stereochemical view of biological activity. Biochem J. 1986 Apr 15;235(2):313-22. Review. No abstract available. PMID: 3017301 [PubMed - indexed for MEDLINE]

3.Subcell Biochem. 2006;39:293-314. Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent.

Parthasarathy LK, Seelan RS, Tobias C, Casanova MF, Parthasarathy RN. Molecular Neuroscience Laboratory, Autism Research Unit, Mental Health, Behavioral Science and Research Services, VA Medical Center (151), Louisville, Kentucky 40206, USA.

Seelan RS, Parthasarathy LK, Parthasarathy RN. E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter. Arch Biochem Biophys. 2004 Nov 1;431(1):95-106. PMID: 15464731 [PubMed - indexed for MEDLINE]

5: Parthasarathy LK, Seelan RS, Wilson MA, Vadnal RE, Parthasarathy RN. Regional changes in rat brain inositol monophosphatase 1 (IMPase 1) activity with chronic lithium treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):55-60. PMID: 12551726 [PubMed - indexed for MEDLINE]

6: Vadnal R, Heng HH, Parthasarathy L, Parthasarathy R. Human chromosomal localization of a gene for inositol monophosphatase by fluorescence in situ hybridization. Neuroreport. 1998 Mar 9;9(4):683-5. PMID: 9559938 [PubMed - indexed for MEDLINE]

7: Parthasarathy R, Parthasarathy L, Vadnal R. Brain inositol monophosphatase identified as a galactose 1-phosphatase. Brain Res. 1997 Dec 5;778(1):99-106. PMID: 9462881 [PubMed - indexed for MEDLINE]

8: Parthasarathy L, Parthasarathy R, Vadnal R. Molecular characterization of coding and untranslated regions of rat cortex lithium-sensitive myo-inositol monophosphatase cDNA. Gene. 1997 May 20;191(1):81-7. PMID: 9210592 [PubMed - indexed for MEDLINE]

9: Vadnal R, Parthasarathy R. Myo-inositol monophosphatase: diverse effects of lithium, carbamazepine, and valproate. Neuropsychopharmacology. 1995 Jul;12(4):277-85. PMID: 7576004 [PubMed - indexed for MEDLINE]

10: Parthasarathy L, Vadnal RE, Parthasarathy R, Devi CS. Biochemical and molecular properties of lithium-sensitive myo-inositol monophosphatase. Life Sci. 1994;54(16):1127-42. Review. PMID: 8152337 [PubMed - indexed for MEDLINE]

11: Parthasarathy L, Vadnal RE, Ramesh TG, Shyamaladevi CS, Parthasarathy R. myo-inositol monophosphatase from rat testes: purification and properties. Arch Biochem Biophys. 1993 Jul;304(1):94-101. PMID: 8391785 [PubMed - indexed for MEDLINE]

12: Parthasarathy R, Parthasarathy L, Ramesh TG, Devi CS, Vadnal RE. The effects of lithium isotopes on the myo-inositol 1-phosphatase reaction in rat brain, liver, and testes. Life Sci. 1992;50(19):1445-50. PMID: 1315412 [PubMed - indexed for MEDLINE]

Hair Care

This seems a little dubious, and the reference is really rather flimsy. Maybe it should be removed, or some proper reference found? --86.13.113.184 (talk) 17:32, 2 January 2009 (UTC)

Incorrect chemical structure

I have moved the following statement from the article: Please note that the synthetic scheme shown here is wrong, because it depicts L-glucose instead of D-glucose as starting material

File:Inositol biosynth.png

Inositol biosynthetic pathway.

It does appear that the diagram is incorrect, so I have removed it.-- Ed (Edgar181) 19:58, 9 January 2009 (UTC)

PEBill (talk) 04:39, 2 May 2013 (UTC)

Vitamin Declassification

While I understand that Vitamin B8 is no longer commonly used to refer to inositol, the statement that vitamins are "declassified" if found to be produced by the body is inaccurate. Vitamin D comes to mind, for example. I'm sure there's a nugget of truth to the statement, but it needs to be further clarified (though, perhaps not in the lead). — trlkly 06:41, 3 May 2009 (UTC)

Big image skewes the page

..and all the text is moved down, leaving a huge hiatus. My resolution is 1024x768. Cheers. --CopperKettle 08:17, 8 September 2009 (UTC)

The relationship between myo-inositol and Vitamin B doesn't seem to be closely associated.....

according to Google scholar

• http://scholar.google.com/scholar?hl=en&q=myo+inositol+vitamin+B&btnG=Search&as_sdt=2000&as_ylo=&as_vis=0
• http://scholar.google.com/scholar?as_q=myo+inositol+vitamin+B&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=title&as_sauthors=&as_publication=&as_ylo=&as_yhi=&as_sdt=1.&as_sdtp=on&as_sdts=5&hl=en

--124.78.210.114 (talk) 10:00, 11 February 2010 (UTC)

Look at that....

• http://www.commonchemistry.org/ChemicalDetail.aspx?ref=83-86-3

--124.78.210.114 (talk) 10:11, 11 February 2010 (UTC)

• http://search.ccinfoweb.ccohs.ca/ccohs/jsp/search/search.jsp?QueryText=83-86-3&Search.x=51&Search.y=15&Search=Search&MaxDocs=500&ResultStart=1&SortSpec=Score+desc&hTab=7&vTab=1&hideTabs=F&Coll=cid

--124.78.210.114 (talk) 10:13, 11 February 2010 (UTC)

The two new sections of T & C are based on the following....

• http://www.google.com/search?hl=en&q=inositol+site%3Awww.usp.org&btnG=Search&aq=f&aqi=&oq=

--124.78.210.114 (talk) 10:30, 11 February 2010 (UTC)

confusing "Psychiatric conditions"

Does (my bolding)

"Some preliminary results of studies on high dose inositol supplements show promising results for people suffering from problems such as..."

conflict with

"Research suggests that lithium functions primarily by decreasing myo-inositol concentrations in bipolar patients",

because of the contrast between "high dose" and "decreasing",

or do the qualifiers "some" and "suggests" make this seemingly illogical logic, logical again?

SalineBrain (talk) 03:44, 25 August 2010 (UTC)

Sweetness

That inositol is "sweet" seems to be beyond dispute, that was already in the article. What I've removed is that it is "almost tasteless" which is both contradictory with its being anyways sweet and judgmental/POV. As it's a common food additive, I'm sure its sucrose equivalence can be found for the common pure form. Anything that is "sweet" is obviously not "tasteless" nor nearly so. 72.228.177.92 (talk) 02:11, 28 January 2012 (UTC)

If in fact it is "nearly tasteless' then (so far as sweetness is concerned) it should have a sucrose equivalence of near zero. My WAG is that it will turn out to be a more than half as sweet. 72.228.177.92 (talk) 02:36, 28 January 2012 (UTC)

The correct term is "relative sweetness." What inositol's relative sweetness is, is not commonly available on the web. This site [1] says it is about 50% that of "sugar" (whatever "sugar" means-- probably common sucrose). This other Chinese manufacturer does say 50% of sucrose [2] Inositol tastes far less than half as sweet as table sugar to me, but I freely admit that this is the kind of thing that is likely to vary from person to person, and concentration to concentration. Nothing wrong with my sense of taste that I know of (and no, I don't smoke). SBHarris 04:51, 28 January 2012 (UTC)

I'm satisified that the matter of fact, illucidated by me has been confirmed by you, you and jan1138 can go ahead and push your spin on those facts without further involvement from me. If in your minds half as sweet as sugar is "nearly tasteless" well alrighty then. 72.228.177.92 (talk) 13:16, 28 January 2012 (UTC)

No, the best cite I can find is "half as sweet," So that's what I'll go with for now. I'm not going to push my personal taste-experience on this article. I only did that because that was the best could do at the time. Again, this is NOT a commonly known or easly-found fact. SBHarris 17:22, 28 January 2012 (UTC)

Actually it is quite easy to taste it. The current article also doesn't mention, nor did I above that it has a folk name, viz. "muscle sugar". 98.4.112.204 (talk) 23:44, 17 December 2021 (UTC)

Chemical Structure

Can someone adapt/redraw this: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=656792 for the chemical structure of the inositol? Looks awfully profesional. Maybe it's not copyrighted.

Showjumpersam 21:25, 17 February 2007 (UTC) This is not inositol. It's distearoylphosphatiylinositol, a metabolic derivative of inositol. It's not that professional and the structural image is not copyrightable. Additionally, it is incorrect. It would appear that one of the fatty acids should be oleoyl (as opposed to stearoyl) however this is not drawn correctly.

Why does "cyclohexitol" redirect here?

Not used or explained in article. 86.159.197.174 (talk) 14:55, 22 August 2014 (UTC)

Is this substance formerly (in 1950s era) known as vitamin-I

I come across on old finnish tradegoods and their chemistry book (published 1954) shortly noting that vitamin I would have protective effects againts pneumonia. With short googling I found my self at this page. Also were pointed out that good source for vitamin-I would be Ribes nigrum, Blackcurrant (locally I assume). I do lack of chemistry knowledge so I just write this note here. LV 2015.

Precision

This article is about inositol, not just myo inositol so to begin it by stating that inositol is more precisely myo inositol is incorrect and confusing because, as is explained later in it, there are forms of inositol that are not myo inositol. The article should begin by discussing inositol in general and then describing myo inositol under a separate heading 209.93.146.3 (talk) 03:39, 30 October 2022 (UTC)