Talk:Interleukin 4

Wrong genome location?

The gene is listed as being on chr11, but I believe it should be Chromosome 5: 132,673,986-132,682,678. Source: https://uswest.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113520;r=5:132673986-132682678 — Preceding unsigned comment added by Auton1 (talk • contribs) 20:24, 3 September 2022 (UTC)

Secretions?

What cells secrete IL-4? —The preceding unsigned comment was added by 129.81.7.252 (talk) 17:45, 6 September 2006 (UTC)

It's not known what cells produce/secrete IL-4. I'm correcting the article to state that IL-4 is NOT secreted by Th2 cells, but instead induces differentiation of Th0 cells to Th2 cells. Cajolingwilhelm 00:28, 13 June 2007 (UTC)

Last month came out an article saying Basophils produce IL4. Here is the link[1] Nunf (talk) —Preceding comment was added at 19:41, 7 May 2008 (UTC)

Article moved

I moved this article and the talk page from Interleukin-4 to Interleukin 4 in order to make this article title consistent with all the other interleukin articles. — Twisted86 - Talk - at 20:33, 28 September 2006 (UTC)

isotypes

i believe IL-4 also helps isotype switching to IgG... if this is correct, then is IgE > IgG? this doesn't make sense overall, though, because IgG is more plentiful than IgE in general... 71.234.109.192 06:53, 12 October 2007 (UTC)

Downregulation of Th2

IL-4 stimulates the Th0's to differentiate into Th2 cells. Then, the Th2 cells produce IL-10 and this is actually what downregulates the Th1 response and NOT the IL-4 itself. Please correct me if I'm wrong, but isn't this fact the case instead of what's in the article? — Preceding unsigned comment added by 131.247.244.172 (talk) 16:17, 19 November 2011 (UTC)

Suspected link with AMD

Raised levels of IL-4 associated with AMD - and may recruit bone marrow cells.[2] - Rod57 (talk) 19:19, 7 May 2020 (UTC)