Talk:Isoflurane

Alzheimers?

Isoflurane is implicated in causing Alzheimers. See the related articles:

http://www.delnor.com/blank.cfm?print=yes&id=154&action=detail&ref=17193 Anesthetic Linked to Alzheimer's Risk

http://www.medpagetoday.com/Neurology/AlzheimersDisease/tb/5008 Cell Culture Experiments Link Florane to Dementia

http://www.rxpgnews.com/alzheimersdisease/isoflurane-may-set-off-a-process_printer.shtml Alzheimer's Isoflurane may produce Alzheimer's-like changes in the brain By Massachusetts General Hospital, Feb 8, 2007 - 3:56:30 AM

http://news.bbc.co.uk/2/hi/health/6334263.stm Anaesthetic linked to Alzheimer's —Preceding unsigned comment added by NescioNomen (talk • contribs) 18:40, 2 October 2007 (UTC)

There are many other articles that support this research. Please add to this list, along with your comments and personal experience.

When talking about science "Cause" is a very big word. When you say "there are many other articles that support this research", probably you are not really aware what a primary font is. The links that you gave are just from some news websites, and they all refer to the same study.

That isoflurane *may* increase the risk of Alzheimer is still very debatable.

1) When looking at properly peer-reviewed articles (i.e. not just news site, but for instance by searching Pubmed) you will see that a query "isoflurane alzheimer" only returns 18 articles most of which do not refer to isoflurane causing Alzheimer's.

2) There are only 2 main articles that "prove" the link: they are from one single group, and the study have been made on cell cultures, not in vivo.

3) In a real situation is a) very unlikely that a person would be exposed to the same doses of isoflurane for so long (6h) and b) very unlikely that this exposition would be continued in time.

So, definitely I would not say it is so indispensable to add that to the article. Gould80 (talk) 15:15, 11 June 2010 (UTC)

Analgesia

The article claims that isoflurane has an analgesic effect without citing any source. This is very disputed (e.g. a study that claims the opposite: http://bja.oxfordjournals.org/content/75/1/55.short), in general inhalational anaesthetics are not considered to be analgesic.

The article you link specifies "subanaesthetic" concentrations. But other reports indicate that in the concentrations used for anesthesia, there is also an analgesic effect. See for example: Improved postoperative analgesia with isoflurane than with propofol anaesthesia. -- Ed (Edgar181) 13:25, 30 August 2011 (UTC)

References

The following list of references was added to the article, but they were not used to support specific content in the article. So I am moving them here in case anyone wants to use them to improve this article. -- Ed (Edgar181) 13:28, 30 August 2011 (UTC)

1. Bigger sized anesthetics may be better Scientific American Mind 7 April 2007
2. Anesthetics and Alzheimer disease probed JAMA April 23, 2007
3. Pravat K. Mandal*, J. W. Pettegrew,” Abeta Peptide interactions with Isoflurane, Propofol, Thiopental and combined Thiopental with Halothane: A NMR Study” Biochemica Biophysica Acta, Biomembrane, (1778: 2633-2639 , 2008).
4. Pravat K. Mandal*, J. W. Pettegrew,” Clinically relevant concentration determination of inhaled anesthetics (halothane, soflurane, sevoflurane and desflurane) by 19F NMR” Cell Biochemistry and Biophysics, (52:31-35, 2008)
5. Pravat K. Mandal* and Vincenzo Fodale :" Smaller molecular-sized anaesthetics oligomerize Abeta peptide simulating Alzheimer’s disease: a relevant issue" European Journal of Anesthesiology, Vol 26(10) Page 805-806 , 2009 - Editorial
6. Pravat K. Mandal*, Daniela Schifilliti, Federica Mafrica, and Vincenzo Fodale "Inhaled Anesthetics and Cognitive Performance" Drugs of Today, (45: 47-54, 2009).
7. Pravat K Mandal*, Vincenzo Fodale "Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: An NMR study" Biochemical and Biophysical Research Communications. (379: 716-720, 2009)
8. Pravat K Mandal*, Virgil Simplaceanu and Vincenzo Fodale : "Intravenous Anesthetic Diazepam does not induce Amyloid beta-peptide Oligomerization but Diazepam Co-administered with Halothane Oligomerizes Amyloid Beta-peptide: An NMR study" Journal of Alzheimer Disease April, 2010
9. V. Fodale, L.B. Santamaria, D. Schifilliti and P. K. Mandal : "Anaesthetics and post-operative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s Disease" Anesthesia Journal (Vol 65(4) page 388-395, April 2010)
10. Juan Perucho1, Isabel Rubio2, Maria J. Casarejos1, Ana Gomez1, Jose A. Rodriguez-Navarro1, Rosa M. Solano1, Justo Garcia De Yébenes2, Maria A. Mena1 Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer'S Disease, Journal of Alzheimer Disease, March 2010