Talk:JoAnne Stubbe

Notability

Stubbe is Distinguished Professor at MIT and is being honored with a prestigious award from the pre-eminent Chemistry society of the USA, for her pioneering work in researching enzymes. Her work is cited as being directly responsible for the development of drugs now being used in the fight against pancreatic cancer. She is a member of a small but significant minority - women who have excelled in one of the more arcane scientific fields. She is listed or cited on several other wikipages now in existence. She is completely worthy of being included in the Wikipedia.Raymondwinn (talk) 05:20, 21 March 2009 (UTC)

References

Another editor seems to think that Chemical & Engineering News, a highly respected and peer-reviewed journal of the American Chemical Society, is a Wikipedia page (possibly because it shows up in blue print on the screen?), and the quote from Dr. Nocera citing the influence of her work also comes from that journal, NOT FROM WIKIPEDIA. Please leave the references in.Raymondwinn (talk) 00:21, 22 March 2009 (UTC)

You need to link to outside sources, not just another Wikipedia page! I've already told you twice, that you can't just link to a wiki page!!! CTJF83Talk 06:33, 22 March 2009 (UTC)

Why in the world do you think I am linking to another Wikipage? What is it about Chemical & Engineering News (a JOURNAL, for crying out loud) that makes you think that it is a wikipage?Raymondwinn (talk) 06:49, 22 March 2009 (UTC)

The wikilink to the journal may have been the cause of the confusion. I've reformatted the reference. If possible, could you include the volume and issue number, the author of the article, and could you make sure that the title of the article is correct? Thanks. --RegentsPark (Maida Hill Tunnel) 08:44, 22 March 2009 (UTC)

Ok, I guess I was just confused by the linking to the Wikipedia articles. My apologies! CTJF83Talk 15:49, 22 March 2009 (UTC)

Awards and Honors Changes

I want to make a new section for the society memberships and remove them from this section.

Also there are additions/corrections to her awards as follows: • 1986 Pfizer Award in Enzyme Chemistry

• 1989 ICI – Stuart Pharmaceutical Award for Excellence in Chemistry

• 1990 MIT teaching award

• 1991 American Academy of Arts and Sciences Fellow Award

• 1992 Myron L. Bender and Muriel S. Bender Distinguished Summer Lecturer, Northwestern University

• 1993 Arthur C. Cope Scholar Award[7] of the American Chemical Society

• 1996 Richards Medal from northeastern section of ACS

• 1997 F.A. Cotton Medal

• 1997 Alfred Bader Award in Bioinorganic or Bioorganic Chemistry[8] of the American Chemical Society

• 1998 F.A. Cotton Medal for Excellence in Chemical Research of the American Chemical Society

• 2004 Repligen Award

• 2005 John Scott Award

• 2008 Protein Society Emil Thomas Kaiser Award

• 2008 National Academy of Sciences Award in Chemical Sciences

• 2008 Kirkwood Medal

• 2009 American Chemical Society's Nakanishi Prize for identifying the role of radical intermediates in ribonucleotide reductase functions.

• 2009 National Medal of Science "for her groundbreaking experiments establishing the mechanisms of ribonucleotide reductases, polyester synthases, and natural product DNA cleavers — compelling demonstrations of the power of chemical investigations to solve problems in biology." [10]

• 2009 Prelog Medal, Laboratory of Organic Chemistry at the Swiss Federal Institute of Technology, Zurich[11]

• 2010 Benjamin Franklin Medal in Chemistry of The Franklin Institute for uncovering the intricate processes by which cells safely use free radicals, for developing new cancer treatments, and for improving the production of environmentally-friendly polymers.[12]

• 2010 Welch Award for "fundamental research in biochemistry and enzymology."[13]

• 2010 Murray Goodman Memorial Prize

• 2014 Penn Chemistry Distinguished Alumni Award

• 2015 American Chemical Society Remsen Award

I have references for the additions, but I am not sure what to do with them on the talk page. Only when to add into the article itself.

Gorrkari (talk) 19:45, 28 March 2016 (UTC)

Scientific Societies - Memberships

I want to make a new section titled: Scientific Societies - Memberships, unless someone else has a better idea.

This is what would be in this section:

• 1991 American Academy of Arts and Sciences[5]

• 1992 United States National Academy of Sciences (Biochemistry section)[6]

• 2004 American Philosophical Society[9]

• American Chemical Society

• American Society for Biological Chemists

• Protein Society

Gorrkari (talk) 19:51, 28 March 2016 (UTC)

Personal Life

I also want to make a new section titled: Personal Life

I couldn't find much about JoAnne's personal life at all, but this is what I did find:

JoAnne’s parents were teachers, and that is why she thought teaching is what she originally wanted to do as a career. JoAnne currently has a pet dog named Dr. McEnzyme Stubbe.

If anyone knows where I can find more personal information about her, please let me know.

Gorrkari (talk) 19:54, 28 March 2016 (UTC)

Edits to Research Section

Addition:

Her first two publications in scientific journals showed the mechanisms for reactions that involved the enzymes enolase that metabolizes carbohydrates, and pyruvate kinase.(6) Her first groundbreaking experiments were carried out in the late 1970s and early 1980s, while she was at Yale, then the University of Wisconsin. She was trying to understand how the hydroxyl group at the 2’ position of the ribonucleotide’s sugar was replaced by the hydrogen found in deoxyribonucleotides. To perform these experiments, she had to synthesize nucleotides that carried a heavy isotope at specific positions. Stubbe reportedly kept a bed in her office since she worked around the clock on her experiments.

Already there:

Stubbe pioneered the use of spectroscopic investigations of enzyme interactions[2] and has devoted most of her career to elucidating the biochemical mechanisms behind free radicals. Stubbe discovered how enzymes called ribonucleotide reductases use free-radical chemistry to convert nucleotides into deoxynucleotides, an essential process in DNA repair and replication

Addition:

These enzymes catalyze the rate-determining step in DNA biosynthesis.

Already there:

Her analysis of the nucleotide reduction process led to a number of applications, including the anti-cancer drug gemcitabine, which is used to treat various carcinomas, such as pancreatic cancer, breast cancer, and non-small cell lung cancer.[1] Stubbe, in collaboration with John Kozarich, also elucidated the structure and function of bleomycin, an antibiotic that is commonly used to treat cancer. They discovered how bleomycin induces DNA strand breaks in tumor cells, which in turn induces apoptosis.[1] In her current research, Stubbe continues to study the function of ribonucleotide reductases and the mechanisms of clinically useful drugs. She has also extended her research into polyhydroxybutyrates, a class of biodegradable polymers that can be synthesized by bacteria under certain conditions and then converted into plastics.

Addition:

Stubbe’s other research interests include the design of so-called suicide inhibitors and mechanisms of DNA repair enzymes.

Gorrkari (talk) 19:58, 28 March 2016 (UTC)

Additional References

1. Patterson, L. (2009, December 14). JoAnne Stubbe’s free radical chemistry | EarthSky.org. Retrieved March 16, 2016, from http://earthsky.org/human-world/joanne-stubbes-free-radical-chemistry

2. Hopkin, K. (2007). JoAnne Stubbe - Making life possible. The Scientist, 21(2), 56-58.

3. Iii, A. B., & Potuzak, J. (2014). The 2010 Benjamin Franklin medal in chemistry presented to Joanne Stubbe. Journal of the Franklin Institute, 351(1), 1-11.

4. Narins, B. (2001). Notable scientists from 1900 to the present. Farmington Hills, MI: Gale Group.

5. JoAnne Stubbe Research Group - MIT. (n.d.). Retrieved March 16, 2016, from http://web.mit.edu/biochemistry/people.htm

6. DCH. (2008). Retrieved March 16, 2016, from http://www.chem.uzh.ch/static/events/dch/2008/Stubbe.html

7. https://biology.mit.edu/people/joanne_stubbe

8. http://cen.acs.org/articles/93/i18/2015-Remsen-Award-JoAnne-Stubbe.html?type=paidArticleContent

9. http://www.chemistry.illinois.edu/events/lectures/Rinehart/2010-11_JoAnne_Stubbe.html

10. https://www.chem.upenn.edu/content/distinguished-alumni-award

Gorrkari (talk) 16:02, 4 April 2016 (UTC)

External links modified

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