Talk:Kupffer cell

Untitled

Page moved moved from Kuppfer cell to Kupffer cell (named for Karl Wilhelm von Kupffer). Rd232 21:48, 16 October 2005 (UTC)

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Note:

Kupffer cells are thought to express little MHC class II and no TLR-4 (Toll like receptor). This is because they are resident in the liver and their job is to remove the large numbers of dying cells from the blood. This means they are taking up a lot of self antigens. Hence, it is vital for them to not be easily activated (to express co-stimmulatory signals e.g. through TLR-4) because otherwise they could easily cause an autoimmune response.

-> I don't have time to put it in.... can someone else phrase it better and do it? The information is up to date and correct. thx

TLR4 is expressed on Kupffer cells.

See Tsung et al 'Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells' Journal of Immunology (2005) 175: 7661–7668.

WikiProject class rating

This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 16:28, 10 November 2007 (UTC)

Kupffer cells <> sternzellen/stellate cells?

This reference [[1]] indicates that Kupffer cells (the monocyte-derived phagocytic cells found in hepatic sinusoids) are not the cells that Kupffer called sternzellen. We may need to rewrite the History section - I will do this when I get the chance, if no one else does it first. --Scray (talk) 04:10, 14 October 2008 (UTC)

Possibly involved in tumour metastasis

[2] says "that resident macrophages called Kupffer cells take up exosomes from the original tumor" as an early step in the formation of a metastasis. - Rod57 (talk) 20:50, 15 April 2016 (UTC)

Function

The function section does not mention how Kupffer cells are a part of what is being described. Can I request an expert to clarify? Aglo123 (talk) 23:52, 26 September 2016 (UTC)