Talk:Lidocaine/Archive 1

Archive 1

Heading

I am a medical researcher, and am looking to find efficent ways to sterilize Lidocane. Anybody have some ideas??

Dissolve in water and filter-sterilize. If you need a solid again, then lyophilize. No offense, but if you really are a medical researcher, you should know this. ~K 17:51, 9 August 2005 (UTC)

Melting Temperature

Lidocaine's melting point is listed as 154˚F. Is it necessary to melt it for administration? Perhaps it is in suspension? I get curious about all manner of esoterica. LorenzoB 07:00, 18 March 2007 (UTC)

Side affects of Lidocaine

I was recently given an injection of lidocaine in my left knee, about 2 hrs later my right leg from the waist down is numb and tingly like it is asleep. Now 2 days later is also is affecting everything from the waist down except my left leg. I asked the doctor who gave me the shot and he said it in no way was related to the lidocaine, but I disagree. Any information would be helpful and appreciated. busdriverwithfour@msn.com

As another user has commented above, Wikipedia does not give medical advice. -60.227.33.74 07:33, 3 March 2006 (UTC)

Lidocaine is a fast-acting, fast-clearing local anesthetic. Very widely used. Anything COULD have ANY side effect! But it would be particularly odd for an injection to the left knee to have only after effects on the right leg. Systemic body-wide adverse effects such as allergy seem more likely. 69.87.194.172 18:41, 7 June 2006 (UTC)

This is an age-old question, usually to do with cars. They replace the fuel filter, and the next day the headlights won't work. It really really seems to the car's owner that, since the lights were perfectly fine until they were in the hands of those garage guys, there must be a connection. You were unlucky enough to have this numbness attack thingie happen while a doctor did something to another part of the body. Humans are naturally pattern-searching creatures. Gaviidae 13:41, 24 April 2007 (UTC)

Age-Dependent Half-Life

First off, apologies for my probable extreme ignorance of the subject. Recently undergoing toe surgery, I had to receive much more lidocaine than the normal dosage, as well as use a tourniquet to induce numbing. The lidocaine wore off after about 45 minutes. According to the doctor, the metabolism of young healthy males eats lidocaine like candy. Is the half life really that dependent on age/sex.health, or do I simply metabolize it faster than average? —Preceding unsigned comment added by Mr bowen2000 (talk • contribs)

That seems faster than normal... but then again, I usually use lidocaine with epinephrine which should help it last longer. Maybe no epinephrine was used? And maybe the surgery was in the upper jaw? Other than that, I do not have any ideas. - Dozenist talk 11:46, 20 December 2006 (UTC)

I was curious about the epinephrine myself, having noticed it listed on the label of the lidocaine ampoule at the dentist's office recently. Maybe this article, or the one on epinephrine, could explain more about this.--207.233.88.250 20:27, 15 February 2007 (UTC)

epinephrine (adrenaline) is used as a vasoconstrictor to counter the vasodilatory effects of lignocaine. This increases the duration of action as well as limits systemic toxicity since the drug is not circulating all around the body.

As an interesting side note, in the Netherlands, lidocaine is "lidocaine" when by itself until they add adrenaline. That's when it's called "xylocaine." for any of you foreign travellers out there : ) Procaine doesn't need the adrenaline added, since it's already a vasoconstrictor. Gaviidae 13:45, 24 April 2007 (UTC)

What does it look like ?

Pics or it doesnt exist k thnx. —Preceding unsigned comment added by 162.83.174.52 (talk) 22:42, 14 November 2008 (UTC)

It is just a white powder or dissolved in liquid. --74.124.187.76 (talk) 21:29, 26 March 2009 (UTC)

Effects on eyes

What effects does lidocaine have on the eyes? Is it safe to use as a topical anesthetic around the eyes? Why do some products with lidocaine say not to use around the eyes? Is it all products with lido, or just certain ones? And what are the risks? --74.124.187.76 (talk) 22:35, 26 March 2009 (UTC)

lidocaine and knee arthritis

has anyone found it effective or non-effective? —Preceding unsigned comment added by 76.24.38.125 (talk) 02:33, 26 April 2009 (UTC)

More toxicology info is needed.....

based on the following http://scholar.google.com/scholar?hl=en&q=allintitle%3A+Lidocaine+toxicity&btnG=Search --222.64.28.66 (talk) 01:23, 10 July 2009 (UTC)

Please do not combine the two chemical formula to one .....

One CAS number identifies one chemical, which is a common practice in pharmacopoeial monographes. The reason behind this concept is that sometimes, one form is toxic and another is not, similar to the casees of mushroom species--222.64.28.66 (talk) 01:36, 10 July 2009 (UTC)

What do you mean? Fvasconcellos (t·c) 01:41, 10 July 2009 (UTC)

Several topics have been added based on the following....

http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=L5783%7CFLUKA&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&F=SPEC --222.64.28.66 (talk) 01:53, 10 July 2009 (UTC)

http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=L5647%7CSIGMA&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&F=SPEC --222.64.28.66 (talk) 01:54, 10 July 2009 (UTC)

Citations

Is it really necessary to have the 'missing citation' markers on everything? Just makes the article look like garbage. bryan986 (talk) 15:35, 28 July 2009 (UTC)

THe CITATION NEEDED everywhere is a bit excessive. And Im not sure what exactly need to be referened in some cases. 82.33.48.96 (talk) 20:02, 24 August 2009 (UTC)

Legality of Lidocaine II

I did a search of controlled substances of California, Michigan and Ohio. Lidocaine was not to be found. While not exhaustive, I believe this section to have gross contradictions to the record. additionally, the citation for WADA is a negative citation - it doesn't mention lidocaine. Perhaps I'm looking in the wrong place, but I beleive this entrie section to be wrong. Comments? 71.31.150.102 (talk) 16:54, 6 June 2010 (UTC) I read someone below who makes a similar claim. I am removing the section. If someone knows what the legal status is, please fix. Thx 71.31.150.102 (talk) 17:03, 6 June 2010 (UTC)

Legality of Lidocaine

I believe the legality of lidocaine recently changed in the USA. I seem to remember that topical aloe vera with lidocaine burn treatments were once illegal, but have recently appeared in stores. Can someone make a comment about this? --Mdwyer 19:58, 30 November 2005 (UTC)

Yes, I bought some topical sunburn relief with lidocaine 1%. — Preceding unsigned comment added by 173.74.44.207 (talk) 07:08, 23 August 2011 (UTC)

Clarification or duplication?

What is the difference between these two modes of administration? Aren't they really the same?

Injected local anaesthetic (sometimes combined with epinephrine to reduce bleeding)

Intravenous injection (sometimes combined with epinephrine to reduce bleeding)

Nutster (talk) 23:12, 15 September 2011 (UTC)

I would think Muscular injection vs Venous injection, though I could be wrong on that. Agree that it is somewhat confusing, though it does seem to be the correct terminology. (forgive lack of log in, just a quick fly-by) VulpineLady 71.51.185.84 (talk) 13:51, 1 October 2011 (UTC)

Lidocaine and Cocaine

What's with the part about Lidocaine mixed with cocaine? I've never heard anything about that. If there is a reference, can someone post it? It sounds like someone is just trying to scare people out of using drugs. —Preceding unsigned comment added by Caribou1107 (talk • contribs) 01:39, 15 October 2007 (UTC)

I don't see how it would scare people off, it just describes a process in which the lidocaine is cut into coke, and the explanation makes sense. --George The Man (talk) 06:14, 19 August 2008 (UTC)

The 'lidocaine' and 'lignocaine' names suggest something based on, derived from, or modelled on cocaine, and I suspect that is exactly what the drug is
Laurel Bush (talk) 18:57, 24 February 2012 (UTC)br

Lidocaine and Bee Stings

Is it okay to put Lidocaine on bee stings?

I and a couple of friends got stung by some yellow jackets yesterday. They were suddenly everywhere. They were incensed!

All of us were stung, but none of us were allergic, so that makes me wonder. Can Lidocaine (Solarcaine) be applied on the site of a bee sting to prevent or delay the sudden swelling (being a symptom of the venom injected, this swelling being an allergic reaction) that some people have to bee stings? Next time I travel into that area, I think I should bring a can of Solarcaine with me.

Is there some other substance that is commercially available that is equally effective? And equally important, is the ready availability of this chemical. 216.99.198.247 (talk) 06:29, 31 July 2012 (UTC)

Mixed with epinephrine

The article says that it is sometimes mixed with epinephrine "to prevent bleeding". I had always heard that the main reason for wanting vasoconstriction (the effect of epinephrine) was to delay the removal of the lidocaine from the area by blood flow - thus prolonging the duration of anesthesia without having to administer a larger dose. Can anyone clarify this?Sbreheny (talk) 03:31, 5 June 2015 (UTC)

Does both. Doc James (talk · contribs · email) 04:50, 5 June 2015 (UTC)

Lidocaine and snake root

I have been told that lidocaine is derived from a plant called Snakeroot. I have now researched both and have not found a connection. I have been told by multiple sources that people here in Kansas U.S.A. go out and pick wild growing Snakeroot and make good money selling it to buyers who use it in Lidocaine manufacturing. Does anyone know or have information in this regard? Please send any info to brmktg@live.com — Preceding unsigned comment added by 98.191.130.139 (talk) 05:48, 5 May 2015 (UTC)

Agree there is no clear connection. "Snake root" is a very imprecise term, with plants carrying this name as diverse as Indian snake root (the origin of reserpine), white snake root (the source of tremetol, the cause of Milk sickness), and Black snakeroot - which is a disambiguation for at least two plants, one of which (Actaea_racemosa) is found in the midwest but does not seem to include lidocaine as a constituent). So, this seems not to belong to the lidocaine article. soupvector (talk) 17:57, 5 September 2015 (UTC)

Freeze versus anaethesia

I prefer the simpler term. Others thoughts? [1] Doc James (talk · contribs · email) 02:46, 5 September 2015 (UTC)

I think "freeze" used like this would puzzle most British readers, & needs further explanation. Anaethesia is a relatively well-understood term, but could be explained a bit too. Johnbod (talk) 02:54, 5 September 2015 (UTC)

The words "freezing" and "anesthesia" are like the words "hot" and "spicy". A food can be hot or spicy or neither or both. Likewise, a patient can be frozen or anesthetized or neither or both. For anesthesia, I recommend the word "anesthesia".

—Wavelength (talk) 03:03, 5 September 2015 (UTC)

"Freeze" is not a synonym for "anesthetize" as far as I know. Certainly, one can anesthetize by freezing (i.e. by applying cold), but that's not what is happening if you use lidocaine above 4°C. I am so puzzled by this I wonder if I'm misunderstanding your intent. soupvector (talk) 03:26, 5 September 2015 (UTC)

I think I've had dentists use "freeze" this way to me ("I'm just going to freeze this tooth"), but I agree it is not right here. Johnbod (talk) 03:31, 5 September 2015 (UTC)

in my view "freeze" is inapt, especially as some aesthetics actually do cause paralysis (what i think when I hear "freeze"). There is a difference between local anesthetic nerve blockers and neuromuscular blockers and lidocaine is the former. what about "numbing" instead of freezing, with a wikilink? Jytdog (talk) 03:46, 5 September 2015 (UTC)

Great suggestion User:Jytdog. I like numbing. Anesthesia generally means putting someone to sleep. Doc James (talk · contribs · email) 04:07, 5 September 2015 (UTC)

[2] several options--Ozzie10aaaa (talk) 08:22, 5 September 2015 (UTC)

the third kind of agent used in anesthesia is a sedative. General anesthesia generally involves all three - pain killer (no pain), paralytic (stays still), and sedative (knocked out).Jytdog (talk) 11:06, 5 September 2015 (UTC)

• "Freeze" is bad, "numb" is good, at least for local anesthetics such as lidocaine. General anesthetics usually don't cause numbness; but that probably isn't relevant to this article. Looie496 (talk) 18:24, 5 September 2015 (UTC)
• Definitely not "freeze". That word should only be used when cold temperatures are involved. It may be colloquial (i.e., something you'd expect an under-educated native speaker to understand) but it will be a disaster for English language learners. Numb is okay. Anesthetize (make numb) might be better. WhatamIdoing (talk) 02:37, 6 September 2015 (UTC)

Yes, go with numb, also with mention of/link to anesthesia. Johnbod (talk) 18:19, 6 September 2015 (UTC)

Supporting math

I updated a sentence that's indirectly supported by this citation. As I needed to calculate the cost per dosage of a 20ml vial here's a table:

Source	Package	Package Price	Unit Price	Num	ml	Total ml	$/ml	$/vial
MEG	20 Amp (20 ml)	$8.96	0.0224/ml	20	20	400	$0.0224	$0.45
SCMS	20 Vial (20 ml)	$9.05	0.0226/ml	20	20	400	$0.0226	$0.45
MEDEOR/EU	20 Vial (20 ml)	$10.16	0.0254/ml	20	20	400	$0.0254	$0.51
AMSTELFAR	20 Amp (20 ml)	$12.00	0.0300/ml	20	20	400	$0.0300	$0.60
IMRES	25 Vial (20 ml)	$18.00	0.0360/ml	25	20	500	$0.0360	$0.72
IDA	10 Vial (20 ml)	$10.42	0.0521/ml	10	20	200	$0.0521	$1.04
MEDEOR/TZ	1 Vial (30 ml)	$0.58	0.0192/ml	1	30	30	$0.0193	$0.58
ASRAMES	25 Vial (50 ml)	$23.44	0.0188/ml	25	50	1250	$0.0188	$0.94
UNFPA	25 Vial (50 ml)	$23.63	0.0189/ml	25	50	1250	$0.0189	$0.95
DURBIN	25 Vial (50 ml)	$26.12	0.0209/ml	25	50	1250	$0.0209	$1.04
AMSTELFAR	25 Vial (50 ml)	$28.95	0.0232/ml	25	50	1250	$0.0232	$1.16
MSD/TANZ	10 Vial (50 ml)	$14.52	0.0290/ml	10	50	500	$0.0290	$1.45

The first four columns are directly from the source document. Num and ml are extracted from the Package column. Total ml is Num times ml. $/ml is Package Price divided by Total ml and was used to check that Unit Price is accurate. $/vial was the number we are interested in and is Package Price divided by Num. I then sorted the table by ml and then $/vial to get the range of prices for 20ml vials. --Marc Kupper|talk 01:25, 17 October 2015 (UTC)

How long does it last?

The lead has "When used as an injectable it typically begins working within four minutes and lasts for half an hour to three hours." The "Pharmacokinetics" section has "The onset of action of lidocaine is about 45 to 90 seconds and its duration is 10 to 20 minutes."

The lead and Pharmacokinetics sections conflict quite a bit in terms of the speed of onset and how long it's effective. I don't understand the subject and technical nomenclature well enough to know which is right or if both are right how to have them make sense to a lay person.

The Pharmacokinetics section also has "The elimination half-life of lidocaine is biphasic and around 90–120 minutes in most patients." This is confusing to me, and likely others that do not have a background in pharmacology. I suspect it's necessary information for a medical text but do we need it on Wikipedia? The word "biphasic" is not defined. See Talk:Drug metabolism#Biphasic where I wrote a note about this. --Marc Kupper|talk 01:00, 17 October 2015 (UTC)

The local numbing effect's duration will depend on a wide variety of factors that could vary from site to site, even in the same person, including rate of fluid exchange, pH, local metabolism, and other factors summarized here: PMID 17175824 . The effect when injected intravenously is governed by the cited half-lives, which depend more on metabolism. The ref I provided may help; I will try editing for clarity when I get a chance. — soupvector (talk) 03:13, 17 October 2015 (UTC)

U.S. schedule

I have looked and can't find the U.S. schedule for this...it's not in schedule lists that I could find. It is prescription, and that's all that I could verify. -Nathan J. Yoder 06:48, 24 March 2007 (UTC)

It is not a DEA scheduled drug in the U.S., it is available in both over-the-counter and Rx preperations. -- Dougie WII (talk) 15:27, 2 April 2017 (UTC)

External links modified

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How do you verify a removal?

@Whywhenwhohow: you seem to want verification that the AAN has been updated to lidocaine, but how am I meant to verify a removal? If I added something it'd be easy to know how to verify, simply put the ref after what I added, but if there's nothing there because I removed what was, how am I meant to verify that? I have a source if all you need an informal verification mentioned in the edit summary, namely https://www.tga.gov.au/updating-medicine-ingredient-names-list-affected-ingredients shows that the preferred name is now lidocaine with lignocaine, the old name, shown in brackets. The Australian Medicines Handbook also has an entry on it, that specifically mentions that AANs are being changed to INNs where possible. Fuse809 (contribs · email · talk · uploads) 07:29, 16 February 2020 (UTC)

Thanks. Missed that. I updated the article. Whywhenwhohow (talk) 19:40, 16 February 2020 (UTC)

Side effects of Lidocaine

Shortly after receiving an injection of Lidocaine as a anesthetic to remove a splinter in my finger, I had a gout attack. I have been on Allopurinal for 15 years and have not had any attacks. Is this just coincidence or could there be any connection between the two?

My last gout attack happened after a dental procedure. However, I had NO anathesia. So, if there is a connection, I suspect it was the stress involved, and not the drugs. --Mdwyer 19:58, 30 November 2005 (UTC)

Please also remember that Wikipedia does not give medical advice. 65.95.235.43 22:17, 1 December 2005 (UTC)

Effect on acetylcholine in human body. Like the release of histamine.

That's interesting ! In terms of modern educational methods, the "XXL Governement".

 :Cher Admin de la Web site. Dear friends, Wikipedia.org.  Pleass .Dichlorfoss Victime (talk) 15:22, 28 April 2021 (UTC)

Adrenaline vs epinephrine

The subject of the article, and of the reference to additions thereof, is a medication. Epinephrine has its own medication page, so shouldn't this article reference the medication page and not the one for the endogenous hormone adrenaline? Morgan Phoenix (talk) 21:59, 10 May 2023 (UTC)