Talk:Lymphocytic choriomeningitis

Untitled

Lymphocytic choriomeningitis

Definition

Lymphocytic choriomeningitis (LCM) is a viral infection of the membranes surrounding the brain and spinal cord and of the cerebrospinal fluid.

Description

Lymphocytic choriomeningitis virus infection is relatively rare and recovery usually occurs spontaneously within a couple of weeks. Many cases are probably not even identified because the symptoms range from extremely mild to those resembling severe flu. A few patients develop symptoms of meningitis. In some rare cases, the LCM viral infection can spread throughout the central nervous system, and may even be fatal.

Causes and symptoms

LCM is caused by an arenavirus, which is an RNA virus and is a mild cousin in the family containing the much more threatening arenaviruses that cause hemmorrhagic fever. Humans acquire LCM virus from infected rodents by coming in contact with the animals or their excretions. Exposure to the virus is not as unlikely to occur as it seems, because the viral hosts can be common house mice and even pets, such as hamsters and chinchillas. Most cases of LCM occur in fall and winter, when mice seek warmth inside dwellings. Food and dust can become contaminated by the excretions of rodents infected with LCM virus. In 1997, French scientists alerted physicians to suspect LCM viral infection in people who had contact with Syrian hamsters.

The symptoms of LCM occur in two phases. The first (prodrome) stage can produce fever, chills, muscle aches, cough, and vomiting. In the second phase, characteristic meningitis symptoms of headache, stiff neck, listlessness, and nausea and vomiting may occur. In adults, complications are rare and recovery may even occur before the second phase.

The virus is not spread from person to person, except through pregnancy. LCM virus is one of the few viruses that can cross the placenta from mother to child during pregnancy and may be an underrecognized cause of congenital infection in newborns. Infection with cytomegalovirus, Toxoplasma gondii,or LCM virus can appear similar enough in infants to be confused when diagnosed. In cases that have been recognized among infants, LCM viral infection has a high mortality rate (about one-third of the babies studied died).

Diagnosis

LCM can be distinguished from bacterial meningitis by the history of prodrome symptoms and the period of time before meningitis symptoms begin, which is about 15-21 days for LCM.

Treatment

No antiviral agents exist for LCM virus. Treatment consists of supporting the patient and treating the symptoms until the infection subsides, generally within a few weeks.

Possible Australian organ donation cluster

Probably verging on WP:NOR at the moment but might be worth keeping an eye on this story. [1] - cyclosarin (talk) 03:12, 2 March 2011 (UTC)

Correction: it's a new virus related to LCMV. http://www.nbc.columbia.edu/pdfs/Palacios_Arenavirus.pdf cyclosarin (talk) 03:19, 2 March 2011 (UTC)

Seroprevalence estimates

The article states: Seroprevalence is approximately 5% (0.7–4.7%) of the US population. Is the range in brackets supposed to be a confidence interval for the seroprevalence? If so, why doesn't it include the 5% point estimate? If not, it might be necessary to clarify exactly what range those figures refer to. — Preceding unsigned comment added by 137.158.153.203 (talk) 13:14, 3 August 2012 (UTC)

External links modified

Hello fellow Wikipedians,

I have just modified one external link on Lymphocytic choriomeningitis. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

• Added archive https://web.archive.org/web/20060514034908/http://www.cbwinfo.com/Biological/Pathogens/LCMV.html to http://www.cbwinfo.com/Biological/Pathogens/LCMV.html

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

• If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
• If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 17:00, 9 January 2018 (UTC)