Talk:Macrophage

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle53.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 03:04, 17 January 2022 (UTC)

Cleanup!

This isn't coherent at all. - Cymydog Naakka 11:22, 5 Jan 2005 (UTC)

But what are they?

Is each macrophage a white blood cell? -- postglock 15:52, 31 August 2005 (UTC)

Answer: YES

Pronunciation?

What is the proper pronunciation of "macrophage"? I have heard it pronounced as "macro-phayge" as well as "macro-phawge". Is the difference regional, or simply in error?

The former is the most common by far. JFW | T@lk 00:27, 10 March 2006 (UTC)

• Feel free to add IPA pronunciation to the article, I don't know how to do it myself. --Obli (Talk)^? 00:33, 10 March 2006 (UTC)

Macrophage division...???

What i know is that macrophages are of no division...

but this link :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2836521&dopt=Abstract

from public medicine...shows the opposite.

please if you have updated informations support me with 'em

Mohammad Abul-wafa

Image caption

I don't know much about the projection of macrophages, but is that macrophage actually trying to get two particles in one go? The directions of the "arms" looks more like it is focussing on the one "straight in front". // habj 10:40, 9 October 2006 (UTC)

"A Series of changes"

-There is not enough information about the maturation process from monocyte to macrophage. —The preceding unsigned comment was added by Owz182 (talk • contribs) 15:36, 2 January 2007 (UTC).

need abbreviations that professors use for macrophages

Isn't there a couple accepted abbreviations for macrophages? like M(then a greek letter?). What are they? —The preceding unsigned comment was added by 207.151.241.4 (talk) 01:18, 3 February 2007 (UTC).

-MΦ - the greek letter is a 'phi' and is used as an abbrevation for 'phage' --Sarah Morwood 20:49, 9 October 2007 (UTC)

A note about the videos

There appears to be a bug (reported) in the Wikimedia Player that returns an error when "Watch in browser" is attempted from the link in the article. However, the Watch-in-browser (Play-in-browser) feature does appear to work from the link provided on the image description page (i.e. the "(file info)" link).--DO11.10 18:37, 21 June 2007 (UTC)

what?
The following discussion has been closed. Please do not modify it.
Request My IRC nickname (or one of them, at least) is ANGRY_MACROPHAGE. I keep having to explain what an Angry macrophage is. Could someone please add a section to this article explaining it so I don't have to? Raul654 23:46, 1 July 2007 (UTC)

Ito Cells

Ito Cells are Hepatic Stellate Cells and not Kupffer cells.

Redirection from giant cells

The page for "giant cells" redirects to the page for "macrophage". I don't think this is a good idea. There are other "giant" cells in the body. Some multi-nucleate cells form as a result of disease, some form during implantation of the blastula during pregnancy; muscle cells could be considered "giant" (so could neurons). The "giant cells" page should probably be a disambiguation page instead. ajp (talk) 19:03, 8 February 2008 (UTC)

Reference?

Does anyone know where "Macrophages can digest more than 100 bacteria before they finally die due to their own digestive compounds." came from?

Shoko Seike —Preceding unsigned comment added by Timtamholic (talk • contribs) 01:07, 22 August 2008 (UTC)

functions of macrophages

The 24 July 2008 edition of Nature, which has a whole section on inflammation, includes the following (p. 433)

Tissue-resident macrophages constitute 10-15% of most tissues, and their functions extend beyond host defence and the removal of apoptotic cells. Examples are control of the turnover of epithelial cells, regulation of metabolic activity of adipocytes and remodelling of bone (which is carried out by osteoclasts).

Unless I am misunderstand -- and my understanding is only that of an interested amateur -- the Wikipedia article does not mention those functions, though it hints at related functions. However, I lack the expertise to add them to the article. Perhaps someone else can assist ... —Preceding unsigned comment added by 66.92.53.49 (talk) 23:12, 7 September 2008 (UTC)

Neuron?

I can't help but point out that the very first thing you spot in the article is the word NEURON on the right side on top of the photo. I think this is very misleading. although they DO have some function in close proximity with PNS neurons, they are by far not as closely associated with neurons and neuroanatomy as it is being convayed. Immunity would be a more suitable word...Andrei A A (talk) 12:28, 29 May 2009 (UTC)

Resolved. Thank you--DO11.10 (talk) 18:56, 29 May 2009 (UTC)

Lead section

I found the sentence below in the lead. As the lead is there to give an accessible overview of the subject, this seems a bit too specific to me. I'd like to hear some input from others before doing anything with it.
"They can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining."
--JorisvS (talk) 19:57, 9 January 2010 (UTC)

Macrophage activation

I am a new to this subject and I wanted to find out how the macrophage is activated. (I understand that it activates lymphocytes.) I focused on "Role in adaptive immunity" paragraph but it did not address my question. I looked on the web and found this old (?) page that talks about it somewhat. I think you may want to include it in this "Macrophage" entry or create a separate entry called "Macrophage activation." Here is the address "http://www.rndsystems.com/cb_detail_objectname_SP04_MacrophageActivation.aspx". It talks there about Classically Activated Macrophages and Alternatively Activated Macrophages. It looks like this is fairly complex or still unknown problem. -‎ 24.248.198.18 - 21:03, 12 August 2011

Muscle Regeneration

While this section is interesting and provides useful information, much of it reads like an abstract. In particular, the material following

A study conducted in 2006 showcased macrophage influences on muscle repair of soleus muscle on mice [11]...

could be condensed to one or two sentences since details of a single experiment are irrelevant within the scope of the article. I'm not qualified to make such changes and will leave it to someone familiar with the material.
-- Jimmy Hers (talk) 00:49, 3 October 2012 (UTC)

I am removing it. It's lifted almost directly from a single study, it's poorly written, it's redundant, and it's relatively long. Here it is.

A study conducted in 2006 showcased macrophage influences on muscle repair of soleus muscle on mice.[16] The first procedural step was to make sure macrophages are present in the muscle after onset of muscle injury, and then decrease their presence to see what effects were had on the muscle. By using anti-F4/80 to bind to macrophages and render them useless, it was seen that when the second wave of macrophages were depleted, there were many more lesions in the muscle cell membrane between the second and fourth day – showing muscle damage when repairing is supposed to occur. After testing for membrane lesions in both the total amount of muscle fibers present, it was noticed that most of the damage occurred in muscle cells that did not have the second subpopulation of macrophages present. Macrophages depletion prevents muscle membrane repair. When examining muscle regeneration, a significant reduction was found in the amount of myonuclei. Depletion of macrophages was found to cause, between the second and fourth day of repair, much less muscle regeneration compared to muscle with macrophage population.[16] Macrophages promote muscle regeneration between the second and fourth day. To determine the influence of macrophages in muscle growth, muscle cross-sectional area in macrophage-depleted muscle area was measured against two muscle sets: muscle that was injured and had macrophage presence and muscle that was not injured and had macrophage presence. The macrophage-depleted muscle showed less growth after four days, and injured muscle with macrophages nearly grew back to the level of uninjured muscle.[16] Macrophage depletion reduces muscle growth during a growth period. The study attempted to examine the appearances of Pax7 and MyoD, but data was not consistent with previous findings.

173.25.54.191 (talk) 00:50, 10 May 2014 (UTC)

Orphaned references in Macrophage

I check pages listed in Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of Macrophage's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.

Reference named "Santoro":

• From Wound healing: Santoro, M.M.; Gaudino, G. (2005). "Cellular and molecular facets of keratinocyte reepithelization during wound healing". Experimental Cell Research. 304 (1): 274–286. doi:10.1016/j.yexcr.2004.10.033. PMID 15707592.
• From Isothermal microcalorimetry: Santoro, R (2011). "Real-time measurements of human chondrocyte heat production during in vitro proliferation". Biotechnology & Bioengineering. 108 (12): 3019–3024. doi:10.1002/bit.23268. PMID 21769860. {{cite journal}}: |access-date= requires |url= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)

I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 06:11, 5 October 2013 (UTC)

Fixed ? - No Santoro ref any longer - Rod57 (talk) 11:38, 5 August 2017 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Macrophage/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Under the heading of "Role in specific immunity" it mentions that it is the TH1 response which promotes the humoral response (B cell maturation). Last time I checked it was the TH2 response which is capable of this. The TH1 response actually inhibits B cells from maturing and producing antibodies.

Last edited at 23:40, 3 March 2008 (UTC). Substituted at 22:45, 29 April 2016 (UTC)

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Lifecycle section could be expanded

It would be great if the Lifecycle section could be updated/expanded to mention the M1 & M2 phenotypes &/or the circulating? macrophages and the tissue resident subtypes. eg do M1 and M2 arise from different cell types or from different activations (clarify) of a single cell type ? - Rod57 (talk) 11:17, 5 August 2017 (UTC)

Should mention inhibition via Signal-regulatory protein alpha

Signal-regulatory protein alpha says that CD47 binding to the SIRP-a on some/all macrophages inhibits their phagocytic behaviour. Could mention somewhere here ? - Rod57 (talk) 12:44, 5 August 2017 (UTC)

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Disease

This section seems like an afterthought with many holes after a list of related diseases was incorporated. It could use additional information on each disease or simply the removal of some if further information is not available.Immcarle53 (talk) 03:03, 16 January 2018 (UTC)

Bibliography

What follows is a list of potential sources and information to add to this page. If anyone has any suggestions or concerns about these articles then please feel free to reply.

Bibliography

Ali, R. A., Wuescher, L. M., Dona, K. R., & Worth, R. G. (2017). Platelets Mediate Host Defense against Staphylococcus aureus through Direct Bactericidal Activity and by Enhancing Macrophage Activities. J Immunol, 198(1), 344-351. doi:10.4049/jimmunol.1601178

Goldberg, E. L., Smithey, M. J., Lutes, L. K., Uhrlaub, J. L., & Nikolich-Zugich, J. (2014). Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol, 193(2), 757-763. doi:10.4049/jimmunol.1400188

Grimm, M. J., Vethanayagam, R. R., Almyroudis, N. G., Dennis, C. G., Khan, A. N., D'Auria, A. C., . . . Segal, B. H. (2013). Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol, 190(8), 4175-4184. doi:10.4049/jimmunol.1202800

Hansen, F. C., Stromdahl, A. C., Morgelin, M., Schmidtchen, A., & van der Plas, M. J. A. (2017). Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria. Front Immunol, 8, 843. doi:10.3389/fimmu.2017.00843

Kim, J. H., Lee, J., Bae, S. J., Kim, Y., Park, B. J., Choi, J. W., . . . Yuk, J. M. (2017). NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection. Sci Rep, 7(1), 6361. doi:10.1038/s41598-017-06610-4

Leopold Wager, C. M., & Wormley, F. L., Jr. (2014). Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections. Mucosal Immunol, 7(5), 1023-1035. doi:10.1038/mi.2014.65

Verma, A., Kroetz, D. N., Tweedle, J. L., & Deepe, G. S., Jr. (2015). Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. Mucosal Immunol, 8(2), 380-389. doi:10.1038/mi.2014.75

Weiss, G., & Schaible, U. E. (2015). Macrophage defense mechanisms against intracellular bacteria. Immunol Rev, 264(1), 182-203. doi:10.1111/imr.12266 Immcarle53 (talk) 20:02, 28 January 2018 (UTC)

@Immcarle53:I can in no way speak to any of the technical aspects but you absolutely have the right idea. Please go ahead and be bold and if their are any issues I'm sure they will be easily handled. Thanks for working on the wiki! Gabriel syme (talk) 07:55, 29 January 2018 (UTC)

I went ahead and added a new section to this article titled "Intestinal Macrophages" and a subheading of its role in disease. Immcarle53 (talk) 00:44, 7 March 2018 (UTC)

Wiki Education assignment: Immunology 2023

This article was the subject of a Wiki Education Foundation-supported course assignment, between 4 January 2023 and 10 March 2023. Further details are available on the course page. Student editor(s): Immcarle188 (article contribs).

— Assignment last updated by Immcarle198 (talk) 16:48, 28 January 2023 (UTC)

what are “larges?”

Should the second paragraph start with “these phages” or just “macrophages” instead of “these larges?” It looks like autocorrect failure. James.d.carlson (talk) 12:34, 16 February 2023 (UTC)

Just go ahead an correct it. Looks weird to everyone. Jonnyboy5 (talk) 08:38, 22 February 2023 (UTC)

Inches

I am sympathetic to the need to present different measurement systems, but in science even in the US, the inch is not used and is not very useful as a unit of measurement when compared to microns. I would suggest removing the reference to inches, since it doesn't really add anything to the article. Jonnyboy5 (talk) 08:40, 22 February 2023 (UTC)

Expression of galectins

The article is lacking discussion of macrophage expression of galectins, such as galectin-3 and the role in disease. There are many research studies that implicate macrophages in disease via the galectin-3 pathway. 107.194.133.235 (talk) 02:55, 29 November 2023 (UTC)

Wiki Education assignment: Academic Writing II

This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 March 2024 and 13 May 2024. Further details are available on the course page. Student editor(s): JJ,1of1, AUS (article contribs).

— Assignment last updated by JJ,1of1, AUS (talk) 18:04, 14 March 2024 (UTC)