Talk:Mebendazole

Different Dosage advice, lack of citation

The dose section is contrary to what my Pediatrician just prescribed for my child's pinworm infection. We were prescribed 2 x 100mg tablets to be taken two weeks apart. This at least partially contradicts the dose section. It appears inaccurate and has no citations.

—Preceding unsigned comment added by 72.85.131.243 (talk) 02:46, 11 June 2009 (UTC)

I too had a different dosage... My doctors have given me 2x100 mg a day, for 3 days

70.164.194.201 (talk) 15:47, 24 August 2010 (UTC)

Mechanism of action is poorly written

Mebendazole blocks polymixin based microtubule formation, destroying the glucose uptake receptor in the nematode. This article is poorly written and incorrect.

What exactly is the mechanism of action of this drug, the article mentions both glucose uptake inhabition and preventing spindle formation, vastly different actions. Which is it? Both?

Onco_p53 00:00, 16 March 2006 (UTC)

Information from the manufacturers website

I agree that this is an incredibly badly written page. What does "selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestine where helminths dwell" mean? That the drug prevents the host's intestine from absorbing these nutrients? So it kills the patient?

The manufacturers website says that it prevents the worms taking up glucose and they die because of lack of energy.

Comrinec (talk) 01:51, 1 August 2008 (UTC)

Image filenames ends in .svg.png which trigger some email malware scanners

Image filenames ends in .svg.png which, when the content is emailed, is identified as an attempt to hide the file ending by some email malware scanners. Please re-name all the image files, removing the .svg parts! --Leif Erlingsson (talk) 15:45, 16 October 2012 (UTC)

CAS registry have no information about history of discovery of this medicine

The main links, like CAS registry, have no information about history of discover and/or massive use. PS: the "Date of Entry" (1974) of CAS is not the "entry year". --Krauss (talk) 19:05, 29 December 2013 (UTC)

Cost in Brazil

In Brazil 400 mg Albendazole costs about US$2.00.

— Preceding unsigned comment added by 177.105.203.119 (talk) 00:10, 24 January 2017 (UTC)

Inconsistent single dose cost in the USA

Which is it? Currently the article claims both:

“In the United States a single dose is about 18 USD.[3]”

“In the United States a single dose is about 440.00 USD as of 2016, while in Australia and the UK it costs about 5 USD.[8]”

— Preceding unsigned comment added by Polarbear ed (talk • contribs) 13:30, 25 February 2018 (UTC)

Yes in 2015 it was 18 USD in the USA and than it increased to 440 USD in 2016.

Have clarified.

Doc James (talk · contribs · email) 07:37, 26 February 2018 (UTC)

Please leave the see also section there.....

It will be beneficial to the future of international standardization

Links are off topic IMO. Doc James (talk · contribs · email) 05:56, 2 August 2018 (UTC)

Information relating to Ovex Suspension containing Mebendazole

Product information from Boots https://www.boots.com/ovex-suspension-30ml-family-pack-10068980

Information leaflet by Ovex https://www.medicines.org.uk/emc/files/pil.1766.pdf

Pharmaceutical page by emc https://www.medicines.org.uk/emc/product/1766/smpc

2.124.248.60 (talk) 17:13, 13 May 2019 (UTC)

Toxicity of Mebendazole (Toxicology Data Network)

https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3232

Human Health Effects

Human Toxicity Excerpts

Drug Warnings

Populations at Special Risk

Probable Routes of Human Exposure

Animal Toxicity Studies

Non-Human Toxicity Excerpts

Non-Human Toxicity Values

Metabolism/Pharmacokinetics

Metabolism/Metabolites

Absorption, Distribution & Excretion

Biological Half-Life

Mechanism of Action

Interactions

2.124.248.60 (talk) 18:38, 13 May 2019 (UTC)

Regarding UK price in the "cost" subcategory.

Under the Cost subcategory there is this line: "In Australia 6 x 100mg costs approximately US$9 while in the UK this would cost around US$19.[20] and about US$5 in Europe." With the citation linking to an FT article locked behind a paywall. Currently in the UK Mebendazole under the Ovex brand (100mg x 4 tablet dose) are sold online for £6, £6 is about $8 US or just over $11 Australian.

(https://ayp.healthcare/ovex-family-pack-4-threadworm-treatment-tablets) for an example.

In pharmacies in the UK it is often cheaper, but I cannot give you an exact figure. So it seems as though if the $18 price is written in that FT article, it is either incorrect or out of date.

Giardiasis

There is no indication in the use of mebendazole for the treatment of giardia — Preceding unsigned comment added by 87.117.189.244 (talk) 17:39, 6 January 2022 (UTC)

? "In conclusion, the use of mebendazole, which is less toxic with no side-effects, is available and effective on Giardia intestinalis as well as intestinal nematodes, is recommended especially in the areas where giardiasis and intestinal nematodiasis are prevalent and overlap." Sadjjadi, S. M. (2001-06-01). "Comparative Clinical Trial of Mebendazole and Metronidazole in Giardiasis of Children". Journal of Tropical Pediatrics. 47 (3): 176–178. doi:10.1093/tropej/47.3.176. ISSN 0142-6338. Largoplazo (talk) 17:47, 6 January 2022 (UTC)