Talk:Mefenamic acid

I suffer from episodes of gout from every 6 months to 2 years. While in Japan a pharmasist recommended Mefenamic acid and it has been a fast and effective releif for me.

Kundi Vali —Preceding unsigned comment added by 121.245.7.112 (talk) 17:24, 4 August 2008 (UTC)

Lethal Dose?

Can we get a decent reference for lethal dose please. I've checked the British National Formulary and I can't find any indication of a "lethal dose" exactly in there being 2.5g and the BNF would be the most reputible source going. Ball00naticFan (talk) 11:01, 20 January 2011 (UTC) ₩

Cost

I was just reading the Medical Letter and they gave the cost at $426.90 a week, the most expensive of the NSAIDs. Drugs for Osteoarthritis. The Medical Letter, 56(1450):80-84, September 2014. Why is it so expensive? When is it preferred to the much cheaper NSAIDs? --Nbauman (talk) 13:25, 7 September 2014 (UTC)

Alzheimer's hype

There is a bunch of media hype now about a recent study in Nature Communcations (see PMID 27509875). This work was done in transgenic mouse models of AD, not in humans. This is not even a new finding. See PMID 16223958 from 2006 which is the same result from a different angle.

There are two recent reviews of clinical trials of NSAIDs for AD treatment - PMID 25644018 and PMID 22336816 (the most recent Cochrane review). Neither have found any evidence that NSAIDs can treat AD, and found harm that did not outweigh the benefit.

PMID 25227314 is a recent review of NSAIDs for preventing AD - it found that while there is evidence from observational studies that NSAIDs may help prevent AD, randomized clinical trials have failed.

I'll add some content about this in a Research section. Jytdog (talk) 16:25, 16 August 2016 (UTC)

2c from a non-specialist: the 3 reviews of NSAIDs for AD linked in main article refer to other NSAIDs, not Mefenamic acid. The Nature's paper results explicit report that other NSAIDs (like ibuprofen) were not effective in IL-1β release as Mefenamic acid (or Flufenamic etc). So while I agree the reviews are interesting to keep the hype level sane, I think the current text implies a contradictory/negative results that are not necessarily true. 139.82.178.34 (talk) 20:01, 9 September 2016 (UTC)

PMID 22336816 (the cochrane review from 2012) used "mefenamic acid" as one of their search terms and took the published research on it into account

PMID 25644018 did not use "mefenamic acid" as a search term but did use NSAID

PMID 25227314 (the one prevention review) did not use "mefenamic acid" as a search term but did use NSAID

The big picture here is that in WP we don't hype results in animals. Many diseases have been cured hundreds of times in rodents and then failed in the clinic. Jytdog (talk) 20:13, 9 September 2016 (UTC)

The emphasis in the articles you cite is on NSAIDs in general and not Mefenamic Acid--which is what this article is about. See: https://commons.wikimedia.org/wiki/File:NSAID_Alzheimer%27s.jpg Revolveruk30 (talk) 23:44, 6 January 2017 (UTC)

That document at the commons is not a MEDRS source. See WP:SPS. Jytdog (talk) 02:11, 7 January 2017 (UTC)

New review

User:67.11.178.76 about this and this. PMID 16223958 is a ten year old primary source, and PMID 28009077, the review from 2016, discusses only rat studies done with mefenamic acid; it does nothing to change the content that is already here, which is based on a recent meta-analysis of clinical trials. We have cured many diseases in animal models and this is especially true for CNS diseases/conditions. Jytdog (talk) 17:41, 5 January 2017 (UTC)

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