Talk:Methylenedioxybenzylpiperazine

Two things

I added MDMA to the see also section despite the fact that the main topic of the intro that it wasn't the methylenedioxy ring but rather the piper group that causes it's effects. I think they are closely related enough to include. On a side note, I believe studying the effects of this drug could lead to more evidence of the hangover effects of MDMA.

Also, I'm going to add a sentence in the intro stating something along the lines of how little research has been done due to it being so relatively insignificant. — Preceding unsigned comment added by Aglo123 (talk • contribs) 01:54, 24 May 2013 (UTC)

First Comment

This "drug" should not be taken by anyone. MDBZP gives you headaches, nausea and makes you dizzy but it is neither pleasant or enjoyable. The stimulant effects are weak at best and at high doses it causes convulsions. Do not assume that the effects will be similar to ecstasy just because it has a methylenedioxy ring. The effects of this compound are not anything like ecstasy, and anyone who says they are, is probably trying to sell it to you. Do not take this drug! Meodipt 05:12, 25 April 2007 (UTC)

Second Comment

This article cites absolutely NO sources, and the one source that it does cite, PIHKAL, has no mention of MDBZP as far as I can tell. I've read through the whole book, looked through the indexes and skimmed through every entry a second time and found no mention of this drug. Secondly, what clinical trial came to the conclusion that it had only negative side effects? Who is the person who has stated this and how did they come to this conclusion? Did they take a drug that they were told contains this compound? What was the dosage, and how did they know its purity or even whether or not it contained this drug?

Honestly, it probably is good that there is a warning against taking this drug, but there needs to be some quality control on this article, especially considering the fact that a great number of entries on pharamacologically active drugs contain medical information or advice, and that people often make decisions regarding their health based on wikipedia articles.

Finally, the structure of this drug does suggest that it would be active. BZP by itself shares many similarities with the effects of amphetamine and has some effects similar to MDMA. The methylenedioxy component of this compound would very likely increase its lipid permeability and increase its uptake into serotonergic vessicles and more than likely either enhance its 5HT agonist properties or enhance its SERT inhibiting properties. That relationship is seen through a great majority of psychoactive compounds including antidepressants like peroxetine. If someone wants to claim that this compound has no activity, that really needs to be cited, because that would make this compound very unique among a variety of compounds that have increasing activity and selectivity for the SERT (serotonin transporter) and activity as 5HT agonists. Simplistic Linguist (talk) 20:02, 23 February 2010 (UTC)