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Tetrahydropapavarine
editFor anyone looking at the pharmocore of this class of opioid, it is worth noting that tetrahydropapavarine is known to be a moderate-potency opioid analgesic[1] with the (R) isomer also being the active isomer. Laudanosine (N-methyl tetrahydropapavarine) is also a known analgesic but is reported to be weaker suggesting that normethopholine may be the active compound. — Preceding unsigned comment added by 86.30.243.179 (talk) 14:28, 6 June 2012 (UTC)
- No, they are talking about N-(1-butyl-4-phenyl-4-piperidinoyl) tetrahydropapaverine. 70.137.133.242 (talk) 19:27, 1 July 2012 (UTC)
Potent derivatives
editTetrahydroisoquinolines. I. The Preparation and Analgetic Activity of Some 1-Thiophenoxyethyltetrahydroisoquinolines and 1-Phenoxyethyltetrahydroisoquinolines THOMAS A. ; MONTZKA, NANCY, CLADEL AND JOHN D. MIATISKELLA
Inseerting an S=O between the ethyl and the p-Cl benzene drops ED50 to 0.3mg/kg compared to 15mg/kg for codeine. There is no example of the p-NO2 derivative being thus modified - a further search has to be carried out. It could result in a potent opioid. — Preceding unsigned comment added by 213.106.56.145 (talk) 15:11, 8 October 2015 (UTC)
Spelling
editWhy "metofoline"? I always saw "methopholine" in literature. --FK1954 (talk) 23:16, 8 March 2016 (UTC)