Talk:Miglustat

Latest comment: 1 year ago by Kmwittko in topic Mechanism of Action

Price

edit

£4015 for pack of 84! £47.80 per capsule. Most expensive capsule purchased by a children's hospital in the London area. There should perhaps be a mention of the high cost of the drug, can somebody explain why the cost is so high? 82.211.83.9 (talk) 14:17, 22 May 2009 (UTC)Reply

Developing, manufacturing and distributing a drug that brings benefit for only a few hundred patients world wide explains the high price. Especially developing a drug takes years and pharmaceutical companies have to follow stict protocols imposed by health authorities and requiring costly clinical studies. Once approved and authorized for sale, the money gained serves to pay back the money previously spent during the years of development. 212.27.185.253 (talk) 08:27, 23 April 2010 (UTC)Reply
At our children's hospice we have provided suport for a small number of children who have been prescribed this medication. A number of them have had diarrhoea that has responded reasonably well to a lactose free diet. I think this would be worth a mention on this page. 217.41.3.106 (talk) 15:37, 5 March 2013 (UTC)Reply
edit

Hello fellow Wikipedians,

I have just modified one external link on Miglustat. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

  • If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
  • If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 22:50, 29 January 2018 (UTC)Reply

Mechanism of Action

edit

As (correctly) stated under “Chemistry”, “Miglustat is an iminosugar” of glucose, i.e., the O (oxygen) in the sugar ring is replaced by an N (nitrogen). With many enzymes that use glucose (not only glucocerebrosidase), it binds the active side binding glucose, but the enzyme then cannot act, resulting in a reversible inhibition. Other enzyme affected u alpha-galactosidases A (α-GalA), which causes the known gastrointestinal side effects (diarrhea, …). Kmwittko Reference: https://www.ema.europa.eu/en/documents/scientific-discussion/zavesca-epar-scientific-discussion_en.pdf (talk) 19:45, 30 April 2023 (UTC)Reply