Talk:Minocycline

General discussion

I added Solodyn to the list of trade names, but I am not 100% exactly sure if it is a minocycline itself or not... I don't have any expertise in the field. Aaronw 02:52, 18 October 2006 (UTC) (forgot to sign the first time)

Yes, it is. It's just minocycline formulated in extended release form.WolfKeeper 02:19, 18 October 2006 (UTC)

Good stuff, Aaronw and Wolfkeeper. I'm not too sure about all the trade names because some were never used in the UK.

I see someone wants to tidy this article up. OK, but, as far as I can see, the information is more or less right. It's pretty much a question of moving the references down to the bottom and changing the order a bit.

—Preceding unsigned comment added by Evieconrad (talk • contribs) 20:29, 1 November 2006

Should Dentomycin be added to the list? http://www.dental-news.net/prdetail.asp?id=241

I take Minocycline as a treatment for acne, and the side of the bottle contains the warning, "prolonged or excessive exposure to direct and/or artificial sunlight *SHOULD BE AVOIDED* while taking this medication." Perhaps an explanation of this should be added.

"It has also been linked to cases of Lupus, although rarely" Which Lupus? you end up on the disambig page... 81.86.65.92 (talk) 18:05, 28 November 2007 (UTC)

I took minocycline for about two years for my acne and I developed auto immune arthritis at age 17. I added that little bit under the cautions.Mouthforwar17 (talk) 16:49, 10 January 2008 (UTC)

Minocycline and autoimmune hepatitis

My 16 year old twin daughters have developed autoimmune hepatitis as a result of taking minocycline for adolescent acne. Minocycline is listed as one of the triggers of autoimmune hepatitis on the Wikipedia entry for autoimmune hepatitis, yet is missed on the description of Cautions under the entry for minocycline. —Preceding unsigned comment added by 64.228.71.93 (talk) 16:05, 2 February 2008 (UTC)

In that case, add it and cite it! Dmarquard (talk) 22:49, 30 March 2009 (UTC)

Minocycline and Rheumatoid Arthritis

My fifteen-year-old daughter just developed rheumatoid arthritis. She had been taking Minocycline for acne (irregularly- she's not good about taking pills) for several months. This is the only source I have found that states Minocycline can cause RA rather than treat it. Is there any research to support this claim? —Preceding unsigned comment added by 24.161.230.66 (talk) 14:49, 27 June 2008 (UTC)

Side Effects

A full listing from the FDA about Solodyn is here. This is a time-released version of minocycline and is not completely bioequivalent, but it mentions the arthritis and autoimmune hepatitis that others said they were experiencing. There is other information in the document as well.--76.251.253.161 (talk) 16:15, 5 January 2009 (UTC)

Changed the UK words to US words; colour to color, due to reference being in US English. Full version of reference here Maynard ar (talk) 18:15, 18 June 2014 (UTC)

Image

The image with the balls has mixed up an alcohol with a ketone on the far right of the structure. The oxygen should be illustrated as double-bonded to the carbon in the hexane ring, rather than the carbon attached to said ring with nitrogen. That latter carbon's current double-bonded oxygen should be replaced by an alcohol group. I would have changed it but I don't know how. —Preceding unsigned comment added by 134.197.22.120 (talk) 10:35, 11 March 2009 (UTC)

I made the image. The structure is from X-ray diffraction (Nature (2006) 443, 173-179, PDB 2DRD), but I had to put in the bond orders and hydrogen atoms myself. I used the skeletal formula from this 2008 paper to assign the bond orders. Do you have a reference that gives a different structure? If so, post a link to it here so it can be discussed.

Ben (talk) 16:37, 11 March 2009 (UTC)

Depersonalization

I just happened to stumble across the Wikipedia article on depersonalization today and was completely and utterly surprised to see that depersonalization is a side effect of Minocycline. I'm so glad I found this, as I've been having some really uncomfortable experiences lately, but had no idea that it was because of this medication. Anyway, I've added the fact and cited it so others can be warned! Dmarquard (talk) 22:52, 30 March 2009 (UTC)

Incorrect citation of study article in fourth (4th) paragraph of "Anti-inflammatory and neuroprotective" section

I would like to bring attention to a discrepancy in the aforementioned paragraph. According to the abstract for citation #25, (from which, also interestingly, the 4th paragraph borrows amply from) reads that "despite a moderately high pretreatment annualized relapse rate (1.3/year pre-enrolment [sic]; 1.2/year during a three-month baseline period) prior to treatment, no relapses occurred between months 6 and 24. Also, despite very active MRI activity pretreatment (19/40 scans had gadolinium-enhancing activity during a three-month run-in), the only patient with gadolinium-enhancing lesions on MRI at 12 and 24 months was on half-dose minocycline." The second sentence from this quote (which comments on "very active MRI activity") is missing from the article's section.

I call for an amendment of this paragraph to include all pieces of information (the sentences about relapses, about MRI activity and the caveat regarding the half-dose) that are relevant to minocycline's beneficial effects in MS patients.

Cited: http://www.ncbi.nlm.nih.gov/pubmed/17463074 — Preceding unsigned comment added by 98.221.223.26 (talk) 23:34, 21 November 2011 (UTC)

Okay, I'll add the interesting great decrease in MRI enhancing lesions, but you can make such changes yourself. See WP:SOFIXIT. You, too, can edit. SBHarris 03:58, 22 November 2011 (UTC)

Adding a section on use as an antipsychotic

I don't have the vocabulary and background knowledge to write this up myself, but hopefully someone who's watching this page does: There seems to be a lot of press about the possible use of minocycline in treating negative symptoms of schizophrenia ([1] [2] and much more - a quick google search for 'minocycline schizophrenia' turns up an abundance). The coverage seems easily reliable and long-lasting enough to warrant a section in this article, I just don't feel comfortable trying to stick it in myself. ∴ ZX95 ^[discuss] 15:00, 25 February 2014 (UTC)

Minocycline#Research - David Gerard (talk) 17:12, 25 February 2014 (UTC)

Derp. Never mind me... ∴ ZX95 ^[discuss] 19:32, 25 February 2014 (UTC)

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Minocycline Accelerates Neurodegenration in TBI

According to this study: https://www.ncbi.nlm.nih.gov/pubmed/29272357, don't have the brainpower to add this to the article but someone else can. — Preceding unsigned comment added by 2605:6000:EB40:3A00:4D27:6B:E119:C485 (talk) 06:41, 30 August 2018 (UTC)

Scrub typhus

It is also prescribed for scrub typhus. Jidanni (talk) 11:49, 27 November 2019 (UTC)

Side Effect Warning

Please add a similar warning to this article, as well as any other antibiotic article that causes a similar problem. I have permanent slight-yellowing of my teeth caused by some antibiotic when I was very young. Too much time has gone by to know exactly which antibiotic caused it, but I would like to ensure it doesn't happen to other children in the future.

"Children should not take this medication. Minocycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old." from https://www.drugs.com/minocycline.html

Thanks 67.143.180.27 (talk) 03:02, 14 April 2023 (UTC)