Talk:Myokine

Myokines are an important but new topic, with few researchers contributing to Wikipedia at this time

In fact, myokine research is groundbreaking and highly important to exercise physiology. However, I lack the skills and knowledge to format the page in accord with Wikipedia guidelines. I am also an interested layperson in this area of research, not a practitioner. The best references are through the Danish National Research Foundation's Centre of Inflammation and Metabolism (CMI). Here is the abstract from a 2012 overview article:

Muscles, exercise and obesity: skeletal muscle as a secretory organ. Pedersen BK; Febbraio MA Nat Rev Endocrinol 2012; 8(8): 457-465

During the past decade, skeletal muscle has been identified as a secretory organ. Accordingly, we have suggested that cytokines and other peptides that are produced, expressed and released by muscle fibres and exert either autocrine, paracrine or endocrine effects should be classified as myokines. The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain. However, some myokines exert their effects within the muscle itself. Thus, myostatin, LIF, IL-6 and IL-7 are involved in muscle hypertrophy and myogenesis, whereas BDNF and IL-6 are involved in AMPK-mediated fat oxidation. IL-6 also appears to have systemic effects on the liver, adipose tissue and the immune system, and mediates crosstalk between intestinal L cells and pancreatic islets. Other myokines include the osteogenic factors IGF-1 and FGF-2; FSTL-1, which improves the endothelial function of the vascular system; and the PGC-1alpha-dependent myokine irisin, which drives brown-fat-like development. Studies in the past few years suggest the existence of yet unidentified factors, secreted from muscle cells, which may influence cancer cell growth and pancreas function. Many proteins produced by skeletal muscle are dependent upon contraction; therefore, physical inactivity probably leads to an altered myokine response, which could provide a potential mechanism for the association between sedentary behaviour and many chronic diseases.

http://www.inflammation-metabolism.dk/index.php?pageid=21&pmid=22473333

Hopefully someone who knows how could expand the entry on this very important and rapidly developing topic.

I have communicated with Dr. Pedersen, suggesting that someone from her department assist in updating and expanding this page (6 APR 2013). — Preceding unsigned comment added by Lhuntkenora (talk • contribs) 21:53, 6 April 2013 (UTC)

Laurence R. Hunt, Kenora, Canada 21:07, 6 April 2013 (UTC)

Dr. Pedersen has acknowledged my communication, and will be consulting with members of her department about reviewing and possibly upgrading the entry. Laurence R. Hunt, Kenora, Canada 17:06, 8 April 2013 (UTC)

I have considerably updated the entry, and linked it to other relevant topics on Wikipedia, and added short entries on several pages to indicate their relevance to this topic, for example Interleukin 6, physical exercise, BDNF, physical fitness, inflammation, etc.

I would be more than happy for a specialist in the field to review and improve the accuracy and completeness of my additions. Laurence R. Hunt, Kenora, Canada 00:46, 7 October 2013 (UTC)

My understanding is that myonectin was first described in 2011. That is, it is newly-discovered. There is thus no Wikipedia entry for myonectin. Starting such a page is outside the scope of my present competence and interests, but I am recommending that a page for myonectin be established.

My reference is: Marcus M. Seldin, Jonathan M. Peterson, Mardi S. Byerly, Zhikui Wei, and G. William Wong. "Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis." THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 15, pp. 11968–11980, April 6, 2012, doi: 10.1074/jbc.M111.336834 originally published online February 17, 2012.

Laurence R. Hunt, Kenora, Canada 01:47, 14 July 2014 (UTC) — Preceding unsigned comment added by Lhuntkenora (talk • contribs)

The myokine page is of undoubted importance, however, it does need a drastic overhaul. I commend the users who have contributed for their endeavours, but the page contains a very large amount of factual errors, inaccuracies and incorrect citations. I am a researcher within the field and would be happy to begin an overhaul of this topic, however it will take some time. Selorian (talk) 16:01, 23 September 2015 (UTC)

Thanks for that comment Selorian. I expanded the page from about three sentences several years ago, due to the importance of the topic. I have relied mainly on Dr. Pedersen's work, but she has not been able to become involved with this page. Revisions, updates and corrections are welcomed. My longer-term plan was to have a separate section for each identified myokine, and I think this would still be desirable. Are you in general agreement with Dr. Pedersen's findings, or do you have a different perspective? I have noted that several historical entries that altered my original text have led to confusion of dates and milestones, e.g., the date of discovery of the first myokine, etc. I have not had time to make corrections, though I know the present entry is erroneous. Laurence R. Hunt, Kenora, Canada 22:30, 24 September 2015 (UTC) — Preceding unsigned comment added by Lhuntkenora (talk • contribs)

On interleukin 15, I suggest keeping in the information from Dr Pedersen pertaining to reduction of visceral fat mass, as distinctive health problems arising from visceral fat accumulation are a primary focus of her work. That is, the reduction of trunk mass is tied to reduction in visceral fat mass, which in turn is associated with mitochondrial proliferation in white fat cells, converting some to brown fat cells. Laurence R. Hunt, Kenora, Canada 20:20, 25 October 2018 (UTC)

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Quote-heavy

Copyeditor passing by. I was preparing to give this article a workover with the writing, but I noticed that large swathes of this article are quoted from the studies themselves; as much as I like having primary sources to work with they should probably not take up the majority of the page. I am currently contemplating removing the {{copy edit}} tag from the article as the large chunks of quoted text are a bigger problem. —Tenryuu 🐲 ( 💬 • 📝 ) 23:56, 19 May 2020 (UTC)

I think you should proceed as suggested. I contemplated going over it myself, but having seen your comment, I change my mind. — BroVic (talk) 11:16, 20 May 2020 (UTC)