Talk:Myosin light-chain kinase

Addition to the intro:

Numerous forms of MYLK come from the same original transcript but are then modified postranslation in vivo Thus while there are only 4 different genes for MYLK, post translation modifications account for the major diversity of MYLK amongst different cells.



Add a section about Myosin light chain kinase mutation and diseases that arise as a result of misfunctioning.

1.Pulmonary disorders: inability of MYLK to function properly in lung cells creates an imbalance in mechanical forces between adjacent Endothelial and lung tissue cells. An imbalance may result in acute respiratory distress syndrome, in which fluid is able to pass into the alveoli.

a.Within the cells, MYLK provides an inward pulling force; cell-cell adhesion via tight and adherens junctions, along with anchoring to Extra Cellular Matrix (ECM) via integrins, and focal adhesion proteins results and outward pulling force.

b.Myosin light chain pulls the actin stress fiber attached to the cadherin, resisting the force of the adjacent cell’s cadherin.



Peer review

The structure of this article flows well. It has a logical intro with supporting details in the sections following that make it easy to understand. There are a few areas lacking citations, namely the statement in the introduction about the diversity of MYLK, the entire section about function, and the paragraph under mutations discussing pulmonary disorders.

For improvements to the page, the introduction makes note of a great diversity of MYLK due to post-translational modifications to the four MYLK genes; however, the section about isoforms only lists the four genes, so it is unclear where the diversity is. Additionally, the isoform section could have some clarification as to what differences there are between the isoforms beside tissue specificity if there are any. Other than these edits, the page is very clear and well-written with appropriate information and graphics. Good luck finishing it up! Ssbusse (talk) 19:30, 6 March 2018 (UTC)

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Peer reviewers: Ssbusse.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 09:33, 18 January 2022 (UTC)