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Talk:Myristicin

Latest comment: 1 year ago by 71.114.47.49 in topic assorted problems
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Source question

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"It causes brain damage." Is there a source for this claim, is it an absolutely known and demonstrated fact, or just a supposition, and even if supposed, what studies support this? Whig 04:07, 7 Jun 2005 (UTC)

NPOV dispute

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Latest comment: 10 years ago3 comments3 people in discussion

The "probable neurotoxic effects" also need to be properly sourced, and while I would rather not remove information which may in fact be well-established, there seems to be a POV here against use of nutmeg for psychoactive effects, based on the claim that it causes permanent harm, which may or may not even be true. Whig 04:12, 7 Jun 2005 (UTC)

I agree, and think that if nothing else the statement "It causes brain damage." needs to be removed until a reliable source can be found saying that it does. I did a Google search, and the only articles I can find which contain "myristicin" and "brain damage" are unrelated, forum discussions, or WP mirrors. Mistercow 20:33, 20 September 2005 (UTC)Reply


Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells. from pubmed see that, is not an evidence but...


in order to further the completeness of this article there must be information dealing with isolation and solubilities as well as decomposition temperature, method of action, LD50, perhaps a copypasta of the history of the uses. —Preceding unsigned comment added by 68.101.16.212 (talk) 15:14, 23 March 2008 (UTC)Reply


The drug made me extremely sensitive to my senses. Sudden unexpected things caused intense pain. I will never forget lying in bed trying to chill out WHEN SUDDENLY PHONE RINGS PAIN!!!!!!!!!!!!!!! 124.191.134.10 (talk) 12:14, 11 December 2013 (UTC)Reply

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Latest comment: 6 years ago1 comment1 person in discussion

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Material from "Uses" section moved here for further review

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Latest comment: 5 years ago1 comment1 person in discussion

...and editing and return to article, if other editors warrant its inclusion. Here are the parts that were removed, as noted in the Edit summaries, because the content was poorly sourced, or distorted the scope away from many studies of licit uses, to illicit uses of the compound. As well, placing long lists of primary sources at end of paragraph was seen to be a problem, because it ignores WP guidelines (requiring secondary sources), and reduces reader confidence because it makes verifiability of individual facts very difficult. Here is the portion of text moved here:

Nutmeg has psychoactive properties at doses much higher than used in cooking.[citation needed] Although these intoxications may be ascribed to the actions of myristicin, it is likely that other components of nutmeg may also be involved, as ingestion of pure myristicin has been found not to produce the same results obtained from ingestion of the entire nutmeg.[citation needed] ...

Intoxications with nutmeg had effects that varied from person to person,[citation needed] but were often reported to be an excited and confused state with headaches, nausea and dizziness, dry mouth, bloodshot eyes and memory disturbances. Nutmeg was also reported to induce hallucinogenic effects, such as visual distortions and paranoid ideation. Most patients with accidental nutmeg intoxication experience high anxiety and an impending sense of doom after the initial excitation. In the reports, nutmeg intoxication took several hours before maximum effect was reached. Effects and after-effects lasted up to several days.[1][2][3][4][5][6][7][8][9][10]

  1. ^ Burroughs, William S. (1957). "Letter from a Master Addict to Dangerous Drugs". British Journal of Addiction to Alcohol & Other Drugs. 53 (2): 119–132. doi:10.1111/j.1360-0443.1957.tb05093.x.
  2. ^ Demetriades, A. K.; Wallman, P. D.; McGuiness, A.; Gavalas, M. C. (2005). "Low Cost, High Risk: Accidental Nutmeg Intoxication". Emergency Medicine Journal. 22 (3): 223–225. doi:10.1136/emj.2002.004168. PMC 1726685. PMID 15735280.
  3. ^ Quin, G. I.; Fanning, N. F.; Plunkett, P. K. (1998). "Letter: Nutmeg Intoxication". Journal of Accident & Emergency Medicine. 15 (4): 287–288. doi:10.1136/emj.15.4.287-d. PMC 1343156. PMID 9681323.
  4. ^ Brenner, N.; Frank, O. S.; Knight, E. (1993). "Chronic Nutmeg Psychosis". Journal of the Royal Society of Medicine. 86 (3): 179–180. PMC 1293919. PMID 8459391.
  5. ^ Scholefield, J. H. (1986). "Letter: Nutmeg--an Unusual Overdose". Archives of Emergency Medicine. 3 (2): 154–155. doi:10.1136/emj.3.2.154. PMC 1285340. PMID 3730084.
  6. ^ Venables, G. S.; Evered, D.; Hall, R. (1976). "Letter: Nutmeg Poisoning". British Medical Journal. 1 (6001): 96. doi:10.1136/bmj.1.6001.96-c. PMC 1638356. PMID 942686.
  7. ^ Panayotopoulos, D. J.; Chisholm, D. D. (1970). "Correspondence: Hallucinogenic Effect of Nutmeg". British Medical Journal. 1 (5698): 754. doi:10.1136/bmj.1.5698.754-b. PMC 1699804. PMID 5440555.
  8. ^ Williams, E. Y.; West, F. (1968). "The Use of Nutmeg as a Psychotropic Drug. Report of two Cases". Journal of the National Medical Association. 60 (4): 289–290. PMC 2611568. PMID 5661198.
  9. ^ Dale, H. H. (1909). "Note on Nutmeg-Poisoning". Proceedings of the Royal Society of Medicine. 2 (Therapeutical and Pharmacological Section): 69–74. PMC 2046458. PMID 19974070.
  10. ^ Cushny, A. R. (1908). "Nutmeg Poisoning". Proceedings of the Royal Society of Medicine. 1 (Therapeutical and Pharmacological Section): 39–44. PMC 2045778. PMID 19973353.

If editors have the time, please review the material against the sources provided, decide if the material is useful in the article with the new Use content that was added, find relevant secondary sources (to substantiate what is now primary source-only material), remove any material inaccurate to good secondary sources, and return the useful and properly sourced content to the article. 2601:246:C700:2DB2:48E8:C38:B886:A274 (talk) 00:34, 9 June 2019 (UTC)Reply

Sources do not cover claim that myristicin has anticholinergic toxicity

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Latest comment: 3 years ago1 comment1 person in discussion
This is a justification of this deletion: link

In my opinion, the two references listed[1][2] do not support that myristicin has anticholigernic properties. Both are secondary sources that can be tracked back to a case report[3] that goes misrepresented:

  • The case report of hospitalization is of nutmeg intoxication, not myristicin.
  • The case report merely observes the symptoms of nutmeg intoxication resemble the presentation of anticholinergic toxidrome. In fact, the case report remarks that it should not be confused with nutmeg intoxication in the ER. It then states that myristicin is thought to be the principal cause of nutmeg intoxication, which is what the two references seem to have clung onto.

Note for editors: Conflating the effects of myristcin with those of nutmeg is common. Although myristicin is thought to be the main culprit of nutmeg intoxication in the medical world, conclusions about myristicin as an isolated chemical should not be taken from observations of nutmeg. It is not the only substance with pharmacological relevance present in nutmeg. — Tyryny (talk) 21:39, 21 June 2021 (UTC)Reply

References

  1. ^ Gunaydin, Mucahit; Tatli, Ozgur; Altuntas, Gurkan; Uslu, Zakire; Ozsahin, Faruk; Beslioglu, Necla (2017). "Nutmeg Intoxication Associated with Consumption as a Stupefacient". Journal of Emergency Medicine Case Reports. 8 (3): 64–65. doi:10.5152/jemcr.2017.1820. ISSN 2149-9934.
  2. ^ Lee, Bo Kyung; Kim, Jae Hee; Jung, Ji Wook; Choi, Ji Woong; Han, Eui Sik; Lee, Sun Hee; Ko, Kwang Ho; Ryu, Jong Hoon (2005). "Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells". Toxicology Letters. 157 (1): 49–56. doi:10.1016/j.toxlet.2005.01.012. ISSN 0378-4274.
  3. ^ Abernethy, Michael K.; Becker, Lance B. (1992). "Acute nutmeg intoxication". The American Journal of Emergency Medicine. 10 (5): 429–430. doi:10.1016/0735-6757(92)90069-A. ISSN 0735-6757.

assorted problems

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Latest comment: 1 year ago1 comment1 person in discussion

but ? (suggest "that seems") unlikely since no MMDA was found in urine, in the body it produces hallucinogenic effects, - & change both ,s to ;s

Physiological effects - Psychoactive effects - elemicin, eugenol, and safrole - capitalize Elemicin

you see everything glitch all around you, breath? (presumably should be breathe), and morph

Overall, nutmeg is more alike? to? that? of? (change to like) a cannabinoid

Metabolites - Myristicin is also formed? (suggest transformed) into demethylenylmyristicin, (change , to &) dihydroxymyristicin, (recommend changing , to . & deleting rest of sentence)

Research on breakdown of myristicin. - sentence fragment

Toxicity - P450 enzymes in humans, which is (change to are) responsible 71.114.47.49 (talk) 04:56, 3 January 2023 (UTC)Reply

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