Talk:Nicotinamide adenine dinucleotide phosphate

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ATP

Latest comment: 14 years ago4 comments4 people in discussion

I'm a bit confused. Are NADP and NAD related to ATP and ADP? How? Unfree (talk) 16:21, 6 December 2008 (UTC)Reply

They are all coenzymes that are made from nucleotides. Tim Vickers (talk) 20:49, 8 December 2008 (UTC)Reply

I guess NADH is involved in the production of ATP, but NADPH is mainly related to the redox system. —Preceding unsigned comment added by 218.19.163.126 (talk) 06:38, 23 January 2010 (UTC)Reply

NADPH/NADP⁺, NADH/NAD⁺, ATP/ADP/AMP and the nucleic acid adenosine all contain the purine adenine. They are related in that they all share this nitrogenous base in an N-glycosidic bond to a ribose derivative.--Dogtownman (talk) 19:31, 17 March 2010 (UTC)Reply

structural formula

Latest comment: 14 years ago2 comments2 people in discussion

The structural formula at the top of this page is inaccurate. If you compare it to the ball-and stick models at the bottom of the page or to the structural formula at [[1]], you can see that several OH functional groups have been replaced by O^- ions. Could someone please fix this? I don't have time to right now.CeresVesta (talk) 23:34, 25 February 2010 (UTC)Reply

At normal cellular pH levels, the phosphate groups you refer to are deprotonated, i.e. the hydrogens (protons) are removed by water to form hydronium ions and the phosphate ionic forms you see in the image. This is because the pH of the cytosol in a typical cell is at 7.2, whereas phosphoric acid, the fully protonated form of a phosphate, has a pKa value of 2.15 for the first hydrogen and 7.18 for the second meaning that at a pH higher than these values the hydrogens are dissociated more than 50% of the time. The images and the molecular weight are both correct because molecular weights are for the molecule in its pure form, which would be the phosphoric acid form, but illustrating the molecule in its normal environment is more useful and is a better representation.--Dogtownman (talk) 19:16, 17 March 2010 (UTC)Reply

Rename Needed

Latest comment: 10 years ago1 comment1 person in discussion

This article on NADP makes reference almost entirely to NADPH, discussing NADP only in relation to its derived metabolite. The article on NADPH need to have its redirect removed and contain the content of the present article.

This article in turn needs to discuss how NADP is derived and what if any function it serves in it's own right. The cycling of NADPH and NADP also needs discussion.

As it stands it would be very confusing for non expert readers that an article on NADP discusses the high energy hydrogen version of the metabolite almost entirely. --Leopardtail (talk) 19:57, 14 June 2014 (UTC)Reply

Difference between NADP+ and NADPH unclear. Comparison between NAD and NADP would also be helpful.

Ok I think I understand the differences now from google image searching. However, this article did not help and caused some confusion for me.

Seems whether there is a P or not refers to phosphate group at bottom of the ribose. Whereas the H vs + refers to how many double bonds (2 vs 3) occur on the the pyridine ( not sure if that's what you call it, the ring on the other nucleotide that doesn't get the extra phosphate).

It would be helpful if this article clearly spelled this out and showed a structure picture comparing all four of these molecules. I'm not confident in my knowledge of this info and I don't want to use a copyrighted picture, so I'm not going to edit the article myself, but hopefully my comments here are helpful.

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