Talk:Oskar (gene)

Learn more about this page

This article is rated Stub-class on Wikipedia's content assessment scale.
It is of interest to the following WikiProjects:

Molecular Biology: MCB

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Low-importance).

Diptera Low‑importance

	This article is within the scope of WikiProject Diptera, a collaborative effort to improve the coverage of flies on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.DipteraWikipedia:WikiProject DipteraTemplate:WikiProject DipteraDiptera articles
Low	This article has been rated as Low-importance on the importance scale.
	This article has been automatically rated by a bot or other tool because one or more other projects use this class. Please ensure the assessment is correct before removing the `\|auto=` parameter.

Addition of Information

I would like to add this section based off of a new study from eLife.

P Granule Formation

Latest comment: 5 years ago1 comment1 person in discussion

oskar plays role in recruiting other germ line genes to the germ plasm for PGC (primordial germ cell) specification. oskar mRNA locates to the posterior end of an oocyte and, once translated, the short isoform of oskar (Short oskar) recruits germ plasm components such as the protein Vasa and the RNA-binding proteins of the Piwi family, among many others. The long isoform of oskar (Long oskar) has been implicated in creating an actin network on the posterior pole end.

A second role has been discovered that relates to the formation of P granules, or germ granules. These ribonucleoprotein granules are found in every species' germ line cells. Although they are mobile, they typically localize to the nuclei and sit on nuclear pores. This positioning makes them ideal mRNA regulators, as the mRNA must pass through to exit the nucleus. Translational regulation also makes sense due to the granules' close association with ribosomes. These P granules are phase-transition entities, which means that they can display both liquid-like and hydrogel-like properties. This allows them to be very versatile structures, able to dissolve, condense, and exchange their protein content with their environment at will. Recent studies have shown that the short isoform of oskar has another function as the nucleator of nuclear germ granules. oskar recruits vasa to these round granules, then promotes the localization to the nucleus. oskar was ablated to explore the function of these nuclear germ granules. The results showed that the division of PGCs was compromised without oskar, meaning that the P granules play a role in the cell cycle of germ cells. It is still unclear exactly how the nuclear granules interact with certain factors and what factors (proteins, regulators, inhibitors) they interact with in order to regulate cell division.

Elemp46 (talk) 22:04, 8 December 2018 (UTC)Reply

Add topic