Talk:Osteoclast

Why would we need dissolving cells in our bones?

Bone mass is a pokemon home worm digital constantly renewed to ensure maintainece of strength - If bone was formed and left it would lose much strength over time. When bones break they are built again and scuplted away by osteoclasts based on the mechanical stress points on the bone, so these bone cleaving cells also play an important role in fracture healing.

Why would there be a need to decrease osteoblast activity in the event there is a bone fractre?Krob2001 18:28, 15 October 2007 (UTC)

Acid mechanism

In the article: The osteoclast releases hydrogen ions (H2O + CO2 → HCO3- + H+) through the ruffled border into the cavity, acidifying and dissolving the mineralized bone matrix into Ca2+, H3PO4, H2CO3 and water.

How does H2CO3 (a weak acid) somehow dissolve CaPO4 into making H3PO4 (a stronger acid)? —Preceding unsigned comment added by 194.82.50.2 (talk) 15:44, 27 October 2008 (UTC) jy983uyexquwyeuyreuheifuwjfbkjshwuyeeuriwjbjfisducs feyrwe7xwneyrwueyierfbdgifuwgiiergjwisudfdiugfwerowienbdfgsidvgisduvw8mer9efx — Preceding unsigned comment added by 71.194.219.1 (talk) 21:52, 20 January 2013 (UTC)

Merge suggestion

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

The result of this discussion was to merge Odonotoclast into Osteoclast Klbrain (talk) 22:35, 31 March 2016 (UTC)

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It seems that there is enough material to warrant a separate article for Odontoclast, but could absolutely be integrated, as well (i.e.., I don't have an opinion which is better).

But, either way, it would be helpful to expand the discussion of odontoclast. I posted some potential sources in a Odontoclast#Further reading section, but I don't have subject matter expertise to write it.--CaroleHenson (talk) 19:17, 21 December 2013 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Cell size

The text says that osteoclasts are typically 150-200 micrometers in diameter, and that sometimes very large cells with a diameter up to 100 micrometers may occur. Surely the diameter of the "typical" cells is not larger than that of the "very large" cells, so there must be an error somewhere? Nikolaj1905 (talk) 09:10, 20 December 2017 (UTC)

Protein ELM01 involved in regulation

"ELMO1 protein ... promotes the activity of the bone-removing osteoclasts." Bone-loss discovery points to treatment for osteoporosis - could mention when find better/additional source/ref. - Rod57 (talk) 23:44, 28 September 2021 (UTC)