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Need to clarify the HER2-negative
editIs approval only for ER+ if patient/tumour also HER2-negative ? - Rod57 (talk) 04:22, 30 December 2015 (UTC)
What next - PALOMA-2 - EU
editWhen is PALOMA-2 due to report data ? Is it needed for an EU application ? When is an EU application expected ? - Rod57 (talk) 18:02, 30 December 2015 (UTC)
History - Chemistry
editHow was this molecule found ? Is it a derivative or analogue of a natural molecule ? - Rod57 (talk) 19:17, 30 December 2015 (UTC) To partially answer your question, a sustained medicinal chemistry effort was made to identify selective Cdk4/6 inhibitors. A description of the work conducted over many years can be found in the following references: https://pubs.acs.org/doi/abs/10.1021/jm049355%2B Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4, Scott N. VanderWel, Patricia J. Harvey, Dennis J. McNamara, et al, Adapted with permission from the Journal of Medicinal Chemistry, American Chemical Society, Apr 1, 2005, Copyright © 2005, American Chemical Society. (full article is paywall protected). Additional information may be available in the references contained in the footnotes. Continued synthetic work prepared and identified PD 0332991 which would later be named Palbociclib, the Cdk4-inhibiting component in (IBRANCE®, Pfizer Inc.). Structural similarity of the earlier leads to PD 0332991 can be seen: https://pubs.acs.org/doi/10.1021/jm049354h Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6, Peter L. Toogood, Patricia J. Harvey, Joseph T. Repine, et al., Adapted with permission from the Journal of Medicinal Chemistry, American Chemical Society, Apr 1, 2005, Copyright © 2005, American Chemical Society. (full article is paywall protected).JTR26 (talk) 15:32, 21 May 2018 (UTC)
How is it administered
editHow is it administered (oral?, IV?, SC?). How often ? - Rod57 (talk) 17:36, 25 November 2016 (UTC)
Theory/motivation
editWhy is it added to other therapies ? Is it to kill cancer cells, avoid resistance, or reduce side-effects ? - Rod57 (talk) 17:40, 25 November 2016 (UTC)