Talk:Paracrine signaling

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First off, thanks for your interest in paracrine signaling! We worked tirelessly to produce this page for your educational purposes. This page was created for our Developmental Biology class at our university. In this Wikipedia page, you will find that we described both the types of receptors and pathways of paracrine signaling -in addition to what paracrine signaling is all about, of course. Moreover, we described how paracrine signaling affects these receptors and pathways, in terms of transcription of genes and the subsequent responsive function of the induced cell. However, you will also read about the aberrant responses when things go wrong (which we all know can result in serious anomalies and malignancies). Please feel free to contribute to the article, whether it be through content or layout editing, and note any changes in this talk page!

We hope you enjoy the page and learn more about the wonderful world of cell-cell communication.

Best, Developmentalbio (talk) 17:03, 4 April 2013 (UTC) chingla 17:16, 4 April 2013 (UTC) User:jeenah92(talk) 17:28, 4 April 2013 (UTC) — Preceding unsigned comment added by Chingla (talk • contribs)

chingla 07:08, 1 March 2013 (UTC) — chingla 16:10, 14 March 2013 (UTC)

As this article reads ("a form of signalling in which the target cell is close to the signal releasing cell"), the neural synapse would be a form of paracrine signalling. Is this this case? If so, it should probably be mentioned because it's so important; if not, then it should be specifically excluded.

User:karn

Well, neurotransmission could be classified as such, except nobody does so. JFW | T@lk 15:38, 11 January 2006 (UTC)

Also neurotransmission and paracrine signalling is differentiated by the time course and molecular arrangement of the transmission. Therefore while the target cell and releasing cell are relatively proximal in both, the biological nature of the two transmissions are quite discernible. SteveD. —Preceding unsigned comment added by 58.166.82.170 (talk) 23:43, 14 March 2008 (UTC)

Autocrine

The introduction to this article says that autocrine signaling is signaling to other cells of the same type. The Autocrine signalling, on the other hand, says that it's to the same cell, and the definition at Dictionary.com appears to agree with this latter definition. Is the definition given in this article accurate but broader? An out-of-date usage? Just simply incorrect? A correction and/or clarification appears to be in order, but I am not familiar enough with the subject to make the necessary changes. --Icarus ^(Hi!) 00:33, 21 May 2008 (UTC)

I agree with Icarus. Autocrine signaling, as commonly used and as defined in the standard textbook Molecular biology of the cell, is the process of cells "sending signals to themselves". Clearly that signal can also be received by other identical cells, and indeed this is a thought to be a mechanism for differentiation or a 'community effect' where groups of cells respond to a signal better than an isolated cell. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=autocrine&rid=cell.section.3835#3843

Perhaps the introduction can be revised to ' Both affect neighboring cells, but whereas autocrine signaling affects the signal-producing cell and identical cells, paracrine signaling affects cells different from the signaling cell.' CG (talk) 06:15, 10 September 2008 (UTC)

Autocrine factors are secreted or cell surface bound growth factors and cytokines that are expressed by a cell to act on itself or adjacent cells of the same lineage. The emphasis is on the same cell lineage. Therefore this means the same cell type. If the target of action is on adjacent cells of different lineage then it is regarded as juxtacrine actioning. SteveD 13th June 2010 08:24 a.m. —Preceding unsigned comment added by 220.239.124.4 (talk) 22:24, 12 June 2010 (UTC)

Peer Review for Developmental Biology Course

The article provides very specific summaries of the different pathways involved with paracrine signaling factors, especially the major families that pertain to early developmental processes. The language is very scientific and may not be perfectly clear to the average layperson, and there are several basic concepts that may benefit from further explanation. The introduction section should include a brief overview of how a transcription factor works by binding to the promoter or enhancer of the target gene. Clarify that this protein binding is necessary for attachment of RNA polymerase. The section on receptor tyrosine kinases might also specify that IP3 is a derivative of the phospholipids in the plasma membrane. Depalmal (talk) 20:29, 13 April 2013 (UTC)

This article is comprehensive in outlining and discussing the different pathways that are made up of paracrine signaling factors. Each family is described in how they work, what molecules are involved, and how they are relevant in biology, different organisms, and why the are important to study. Much of it is technical and scientific, ok for us in the class, but to the average viewer that may arrive at the page, it might eb overwhelming to be reading all the different terms. Some terms frequently referred to as some sort of acronym and that an average person would not know immediately could be explained a little bit before they are used frequently in the following detailed explanations. Overall, very thorough article, tying together how the pathways work and are important in current research and how it is relevant to human growth and development. Few minor grammatical errors were present. Great article! Olefsky (talk) 22:16, 13 April 2013 (UTC)

References

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<Darnell J.E. Jr , Kerr I.M., Stark G.R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415–21>[2]

<Jiang, J. & Hui, C.C. (2008) Hedgehog signaling in development and cancer. Dev. Cell 15, 801–812.>[3]

<Hooper, J. E. & Scott, M. P. (2005) Communicating with Hedgehogs. Nature Rev. Mol. Cell Biol. 6, 306–317.>[4]

<Rawlings J.S., Rosler K.M., Harrison D.A. (2004) The JAK/STAT signaling pathway. J Cell Sci 117 : 1281 –1283>[5]

<Robbins D.J., Fei D.L., Riobo N.A. (2012) The hedgehog signal transduction network. Sci. Signal., p. re6>[6]

<Nybakken, K. & Perrimon, N. (2002) Hedgehog signal transduction: recent findings. Curr. Opin. Genet. Dev. 12, 503–511>[7]

<Schindler C & Darnell J.E. Jr . (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621–51>[8]

<Yu, H. & Jove, R. (2004) The STATs of cancer — new molecular targets come of age. Nature Rev. Cancer 4, 97–105.>[9]

Developmentalbio (talk) 03:31, 20 March 2013 (UTC)

Cadigan, K., and Nusse, R. "Wnt signaling: a common theme in animal development", "Genes & Development", 1997 11: 3286-3305.

You, Z., Saims, D., Chen, S., Zhang, Z., Gutteridge, D. C., Guan K., Mac Dougald, O. A., Brown, A. M. C., Evan, G., Kitajewski, J., Wang, C. "Wnt Signaling Promotes Oncogenic Transformation by Inhibiting c-Myc-Induced Apoptosis", "The Journal of Cell Biology", Vol 157, No. 3, 29 April 2002, pp. 429-440.

De, A. ["Wnt/ Ca^2+ Signaling Pathway: a brief overview"], "Acta Biochim Biophys Sin" Vol 42, Issue 10, pp. 745- 756, 27 July 2011.

Steitz, S. A., Tsang, M., Sussman D. J. ["Wnt-mediated relocalization of dishevelled proteins"], "In Vitro Cellular & Developmental Biology." Animal, Vol 32, No. 7, pp. 441-445, 22 Nov 1995.

Dale, T. C. "Signal transduction by the Wnt family of ligands", "Biochem J", 329: pp. 209-223, 1998.

Chen, S., Guttridge D. C., You, Z., Zhang Z., Fribley, A., Mayo, M. W., Kitajewski, J., Wang, C. ["Wnt-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor-Mediated Transcription"], "The Journal of Cell Biology", Vol. 152, No. 1, pp. 87-96, 8 Jan 2001.

Chen, X., Yang, J., Evans, P. M., and Liu, C. "Wnt Signaling: the good and the bad", "Acta Biochim Biophys Sin", Vol. 40, Iss. 7, pp. 577-594, 2008 chingla 00:21, 22 March 2013 (UTC) — Preceding unsigned comment added by Chingla (talk • contribs)

Paracrine

Paracrine 27.63.179.136 (talk) 12:34, 15 June 2022 (UTC)