Talk:Paratope

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 4 January 2021 and 15 March 2021. Further details are available on the course page. Student editor(s): Immcarle160.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 06:08, 17 January 2022 (UTC)

Needs more (and better) citations

While this article is succinct and contains many links, its only reference is a nearly 20-page span of a textbook published in 2003. Specifically, a citation is needed for the claimed length range of a paratope (species differences, if any, are not even mentioned), but in general this stub could benefit greatly from the addition of several independent sources - primary literature preferably, but even a couple of recent reviews (Annual Review of Immunology, Nature Reviews Immunology, Cell or one of its relatives, Journal of Immunology, etc.) would be fine. Failing even that, a couple of specific (exact page number and quote) citations from textbooks published in the last five years would work.

Expansion of the article to cover more recent research would also help. There have been quite a number of papers in the last 10 years expanding our knowledge of paratope (and CDR) structure, function, and plasticity, especially as it relates to antibody engineering and humanization, including immunogenicity reduction, for therapeutic purposes. DadOfBeanAndBug (talk) 17:58, 17 May 2017 (UTC) DadOfBeanAndBug (talk) 17:58, 17 May 2017 (UTC)

Editing and Adding Sources

Over the next few weeks, I am planning to work on this page by adding citations and updating some of the material. Here are some of the sources I have so far:

Nuttall SD, Walsh RB (2008). "Display scaffolds: protein engineering for novel therapeutics". Current Opinion in Pharmacology. 8 (5): 609-615. https://doi.org/10.1016/j.coph.2008.06.007.

Abbott WM, Damschroder MM, Lowe DC (August 2014). "Current approaches to fine mapping of antigen-antibody interactions". Immunology. 142 (4): 526-535. doi: 10.1111/imm.12284. PMID: 24635566.

Henry KA, MacKenzie CR (August 2018). "Antigen recognition by single-domain antibodies: structural latitudes and constraints". MAbs. 10 (6): 815-826. doi: 10.1080/19420862.2018.1489633. PMID: 29916758.

Rios M, Criscitiello MF, Smider VV (2015). "Structural and genetic diversity in antibody repertoires from diverse species". Current Opinion in Structural Biology. 33: 27-41. https://doi.org/10.1016/j.sbi.2015.06.002. --Immcarle160 (talk) 00:26, 30 January 2021 (UTC)