Talk:Pelargonium sidoides
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If anyone is interested, this is an information leaflet found in the UK formulation, "Kaloba". http://img9.imageshack.us/img9/1636/dsc00845l.jpg http://img836.imageshack.us/img836/760/dsc00844v.jpg http://img827.imageshack.us/img827/8003/dsc00843ec.jpg http://img824.imageshack.us/img824/3360/dsc00842le.jpg Anareon (talk) 12:12, 25 January 2011 (UTC)
The article needs some informations about the plant. 178.213.166.118 (talk) 16:31, 7 September 2012 (UTC)
Many human studies done in Germany. Are they reliable or biased?
editWikipedia article about Pelargonium sidoides now says:
"A 2013 Cochrane review found tentative evidence of benefit with Pelargonium sidoides root extract for the symptoms of acute bronchitis, the common cold and acute rhinosinusitis; however, the quality of the evidence was low to very low.[1]
A summary of this review found that all studies were "from the same investigator (the manufacturer) and performed in the same region (Ukraine and Russia)".
I haven't read the Cochrane review so I don't know why only Ukraine and Russia are mentioned.
However! I found several very large human studies (hundreds or thousands of humans in each study) that were done in Germany
For example, here are the human studies of Pelargonium & Bronchitis.
https://www.ncbi.nlm.nih.gov/pubmed/12807337 Phytomedicine. 2003;10 Suppl 4:7-17. Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. Matthys H1, Eisebitt R, Seith B, Heger M. Author information. Lungs at Home, Freiburg i. Br., Germany. hmatthys@t-online.de
https://www.ncbi.nlm.nih.gov/pubmed/17184981 Phytomedicine. 2007;14 Suppl 6:69-73. Epub 2006 Dec 20. Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children. Matthys H1, Kamin W, Funk P, Heger M. Author information. Department of Pneumology, University Hospital, Freiburg, Germany. hmatthys@t-online.de
https://www.ncbi.nlm.nih.gov/pubmed/17288687 Curr Med Res Opin. 2007 Feb;23(2):323-31. Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre study. Matthys H1, Heger M. Author information. Department of Pneumology, University Hospital Freiburg, Freiburg, Germany. hmatthys@t-online.de
https://www.ncbi.nlm.nih.gov/pubmed/16781588 Explore (NY). 2005 Nov;1(6):437-45. Treatment of acute bronchitis in adults with a pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trial. Chuchalin AG1, Berman B, Lehmacher W. Author information. Russian Research Institute of Pulmonology, Moscow, Russia.
https://www.ncbi.nlm.nih.gov/pubmed/22360575 Pediatr Int. 2012 Apr;54(2):219-26. doi: 10.1111/j.1442-200X.2012.03598.x. Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents. Kamin W1, Ilyenko LI, Malek FA, Kieser M. Author information. University Hospital Paediatrics, Mainz, Germany'Bold text'. wkamin@evkhamm.de
https://www.ncbi.nlm.nih.gov/pubmed/20387996 Curr Med Res Opin. 2010 Jun;26(6):1413-22. doi: 10.1185/03007991003798463. Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides. Matthys H1, Lizogub VG, Malek FA, Kieser M. Author information. Department of Pneumology, University Hospital Freiburg, Freiburg, Germany. hmatthys@t-online.de
https://www.ncbi.nlm.nih.gov/pubmed/20070280 Acta Paediatr. 2010 Apr;99(4):537-43. doi: 10.1111/j.1651-2227.2009.01656.x. Epub 2010 Jan 11. Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. Kamin W1, Maydannik VG, Malek FA, Kieser M. Author information. University Hospital Paediatrics, Mainz, Germany. wkamin@evkhamm.de
https://www.ncbi.nlm.nih.gov/pubmed/20197012 Int J Clin Pharmacol Ther. 2010 Mar;48(3):184-91. Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots. Kamin W1, Maydannik V, Malek FA, Kieser M. Author information. University Hospital Pediatrics, Mainz, Germany. wkamin@evkhamm.de
https://www.ncbi.nlm.nih.gov/pubmed/18449849 Planta Med. 2008 May;74(6):686-92. doi: 10.1055/s-2008-1074519. Epub 2008 Apr 30. EPs 7630 improves acute bronchitic symptoms and shortens time to remission. Results of a randomised, double-blind, placebo-controlled, multicentre trial. Matthys H1, Funk P. Author information. Department of Pneumology, University Hospital Freiburg, Freiburg, Germany. hmatthys@t-online.de
https://www.ncbi.nlm.nih.gov/pubmed/17184984 Phytomedicine. 2007;14 Suppl 6:65-8. Epub 2006 Dec 20. EPs 7630-solution--an effective therapeutic option in acute and exacerbating bronchitis. Matthys H1, Heger M. Author information. Medical Dir. emeritus, Department of Pneumology, University Hospital Freiburg, Freiburg, Germany. hmatthys@t-online.de <hmatthys@t-online.de>
https://www.ncbi.nlm.nih.gov/pubmed/18222667 Phytomedicine. 2008 May;15(5):378-85. doi: 10.1016/j.phymed.2007.11.023. Epub 2008 Jan 28. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Agbabiaka TB1, Guo R, Ernst E. Author information. Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, UK. taofikat.agbabiaka@pms.ac.uk Erratum in Phytomedicine. 2009 Aug;16(8):798-9. ...
The conclusion from the Timmer paper
editHere is the conclusion from the abstract: "P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified." — Preceding unsigned comment added by 128.178.41.16 (talk) 09:11, 26 October 2021 (UTC)