Talk:Pemoline

Wow... somebody messed up. They placed a link on this page linking to the "official site" of Pemoline. Pemoline is a generic name for a drug.... how can an "offical" site exist? That's like the "Official site" of A.S.A., it makes no sense. (Even if they register a clever domain!) I have to wonder what information they provide when they make a claim like that. I replaced the link with a link to the product monograph. -WH

I wanted to point out, in the article it says it does not cause the loss of appetite that other stimulants do? Well, I took Pemoline from 6 years of age up until 13, and besides putting me in the hurt bag psycologically (which is why I am against giving these drugs to children now), it almost completely suppressed my appetite. In fact, up until I stopped taking it, I was relatively thin. After I ceased taking it, I gained almost 200 pounds over the course of about 3 years and also started to struggle with depression disorders and other mental health disturbances. The fact that a doctor could still find a way to circumvent the FDA recommendation that it not be prescribed on 'sympathetic grounds' is not only appalling, but baffling. —Preceding unsigned comment added by 68.112.156.69 (talk) 02:01, 10 February 2011 (UTC)

External links modified

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• Added archive https://web.archive.org/web/20051205125434/http://www.incb.org/pdf/e/list/green.pdf to http://www.incb.org/pdf/e/list/green.pdf

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No direct evidence for releasing agent activity?

Hello,

I've been trying to verify the claim that pemoline is a releasing agent of dopamine. While I see that this is clearly mentioned in the provided secondary source, the primary source it cites (Iijima 1986) does not make this claim. Furthermore, the actual published FDA pamphlet (FDA 2002) states that pemoline's MOA with regards to dopamine has not been elucidated.

If someone has an original source demonstrating releasing-agent activity, please let me know. At the moment I'm inclined to believe that this is pharmacological hearsay from a time when psychopharmacology was less mature and people were more eager to state mechanistic inferences as fact in their research. Oro Temp (talk) 17:02, 14 July 2024 (UTC)

Found it! https://pubmed.ncbi.nlm.nih.gov/24701/ Oro Temp (talk) 17:17, 14 July 2024 (UTC)