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I don't think penicillin is strictly a I hypersensitivity reaction despite the anaphylaxis and involvement of IgE. According to Janeway's Immunology 8th ed. (pg 572) penicillin allergy is defined as a type II hypersensitivity. Is it possible that depending on the isotype of antibodies generated you get different clinical outcomes? — Preceding unsigned comment added by Porquoicum (talk • contribs) 02:10, 18 February 2015 (UTC)