Talk:Phenylpropanolamine
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Comparison to the methylated amines
editI removed the "citation needed" flag from the section comparing the secondary to the primary amines. It's a basic chemical fact thus needing no further reference. The difference between norephedrine and ephedrine, amphetamine and methamphetamine, cathinone and methcathinone is the methyl group at the nitrogen. —Preceding unsigned comment added by Bur (talk • contribs) 19:35, 5 July 2008 (UTC)
This is simply not correct - the difference between amphetamine and PPA has nothing to do with a methyl group, it has to do with the hydroxy group. When you reduce PPA, it saturates that carbon with a hydrogren. That's the 'meth' in methamphetamine and methcatinone - the methyl group on the nitrogren. Amphetamine is still a primary amine, go read the actual structure. Furthermore, ephedrine is a secondary amine. This article is plain wrong as it stands. —Preceding unsigned comment added by 128.120.66.227 (talk) 22:40, 2 February 2009 (UTC)
I removed the citation needed tags in the chemistry section. The difference between a primary and secondary amine is not "original research." The reduction of a ketone to an alcohol is also extremely well documented and basic, and does not need citation. Apophenic (talk) 10:53, 23 March 2009 (UTC)
Legal Status
editJust wondering if phenylpropanolamine is banned in any major countries, and if so, where? — NRen2k5 13:36, 31 October 2006 (UTC)
I have just added into the article that here in the United Kingdom, it is completely derestricted, saleable by anyone, and actually features in many many every-day cough/cold meds - I'm shocked that there has been so much hassle with it worldwide (to the extent that it has been pulled off shelves!)!! :o Dvmedis (talk) 06:22, 14 March 2009 (UTC)
- Its available everywhere outside the US because the US FDA relied on a single, poorly powered trial to fuel their lawsuit feared ban.Fuzbaby (talk) 19:00, 21 May 2009 (UTC)
It's completely withdrawn for human use in the UK and the rest of Europe, and is no longer listed in the British National Formulary. It's unclear whether it's still legal to import it for personal use. W4rd3n (talk) 16:30, 1 September 2011 (UTC)
Textbox Removed
editThat second textbox starting with Indicated for: wasn't very useful with just one field ("side effects") listed. Unless someone wants to revert and fill in some of the 19 other fields, I've removed it. Also, while I fixed several References, I don't know where to find the data missing from the drugInfoBox, so I placed an {{expert}} tag on the page. — VoxLuna 
(talk) 02:41, 23 September 2006 (UTC)
Optical Isomer Images
editI have created a diagram with the four optical isomers. They are not labeled, however I plan on labeling them very soon. I didn't want to place them on the page yet because of this, and I don't know exactly where they should be placed. Any ideas? Here's the image: Ccroberts 03:17, 18 October 2006 (UTC)
Dexatrim & Phenylpropanolamine
editI'm not a regular poster...so excuse the anonomous post. I wanted to look up dexatrim, and I was redirected to this page. From what I gather on the Dexatrim labels, this is not one of its ingredients. —The preceding unsigned comment was added by 69.129.125.31 (talk) 17:55, 25 April 2007 (UTC).
- I was surprised by this, too. As of 2001, dexatrim no longer seems to contain phenylpropanolamine. [1] [2] !jim 02:03, 10 May 2007 (UTC)
Europe
editI am somewhat annoyed by this article that 'Europe' seems to be repeatedly mentioned as if it is one country, and it is somewhat 'poor' to blanket it, especially when every country is so so so different. Needless to say, Europe has countries such as the UK, France, Spain and Germany - as well as places further east such as Bulgaria, the Czech Republic and some even consider western Russia to be part of Europe. We really need some clarification. I've mentioned the UK specifically in the article, but anyone fancy clearing up what the legal statuses are in other countries of Europe? Dvmedis (talk) 06:27, 14 March 2009 (UTC)
- I was just prescribed 30 tabl. of 50mg Rinexin for use over 14 days, 2 x day (min 8h). Supposed to drain excessive fluids in the inner ear, improving my hearing.
- - Norway —Preceding unsigned comment added by 212.33.129.244 (talk) 08:37, 15 May 2009 (UTC)
For future reference
editI'm offering up the following tidbit in the event those more familiar with the article find it useful or suitable for inclusion. Cheers! Location (talk) 06:37, 5 January 2011 (UTC)
- After finishing fourth in the marathon at the 1992 Olympics, Madina Biktagirova tested positive for norephedrine and became the first Olympic marathoner disqualified for failing a drug test.[1]
- ^ Benyo, Richard; Henderson, Joe (2002). "B: BAA to Bush, George W.". Running Encyclopedia: The Ultimate Source for Today's Runner. Champaign, Illinois: Human Kinetics. p. 34. ISBN 0736037349, 9780736037341.
{{cite book}}: Check|isbn=value: invalid character (help); Cite has empty unknown parameters:|laydate=,|separator=,|laysummary=,|month=,|trans_chapter=, and|lastauthoramp=(help); External link in|chapterurl=|chapterurl=ignored (|chapter-url=suggested) (help)
Stereochemistry in the box
editThere is a 2D-formulae and a 3D-formulae in the box. Both have different absolute configuration. They are diastereomers. Regards, --Jü (talk) 19:15, 18 August 2011 (UTC)
- You are absolutely correct, the box title, the chemical name, and the structure are all at odds. A molecule lacking stereochemical R and S descriptors should not even have a chem box (or be portrayed as a stingle stereoisomer). The article title name refers to a family of related compounds, and not to a single one. I will try to attend to this soon. Le Prof Leprof 7272 (talk) 02:40, 2 June 2014 (UTC)
- File:RS-Norephedrine 2.svg and File:Phenylpropanolamine2.png look like the same stereoisomer to me. There is a conformational difference, with the ball&stick having the N "in the plane" vs wedged forward from C2 in the skeletal. For the stereochemistry to match, the methyl (C3) needs to be coming forward in the ball&stick, which it is, and likewise the H on C2 going away, which it is. One confusion at first glance is that the H on C2 is not the prominent one that looks like it is almost directly in front of C2 (that H has a visible bond to C3), but instead the one that is partly obscured by C3 (that H's bond is also mostly obscured, but is visibly oriented towards C2 when looking at a larger rendering than in the infobox). DMacks (talk) 18:02, 3 June 2014 (UTC)
Is it worth pointing out in this article that Ayds contained PPA? RJFJR (talk) 20:17, 19 December 2011 (UTC)
Use in Canines/Veterinary Use
editI was surprised to find nothing on veterinary use. My vet prescribed this for our dog to help with incontinence and it seems like it is often used for this. I'd like to see a section on this and any potentially adverse side effects in canines. — Preceding unsigned comment added by 99.109.17.32 (talk) 17:32, 29 March 2012 (UTC)
PPA used to make cathinone
editSignificant enough to add to the article? Boltushka: A Homemade Amphetamine-Type Stimulant and HIV Risk in Odessa, Ukraine http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823117/ --Custoo (talk) 01:03, 9 January 2015 (UTC)
Strange "reference notes" section?!
editWhat's up with that, how is that supposed to be useful? -- 2001:14BA:8300:0:0:0:1:624C (talk) 15:29, 3 May 2017 (UTC)
- That sources listed are the ones used for the flowchart in the Pharmacokinetics section. So it is very useful.MartinezMD (talk) 01:13, 3 December 2017 (UTC)