Talk:Phosphoinositide 3-kinase inhibitor

Initial focus

Inhibitors of gamma and delta isoforms of PI3K in particular. Rod57 (talk) 19:22, 9 July 2010 (UTC)

Need results of clinical trials

Especially any phase III or even II. Rod57 (talk) 12:32, 25 August 2010 (UTC)

Could describe effects of inhibiting different isoforms

• Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors

Rod57 (talk) 10:58, 20 October 2010 (UTC)

PI-103

[1] says "PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively." and implies there have been some clinical trials.
[2] says some derivatives of PI-103 such as GDC-0941 have been in clinical trials. Also "GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively". - Rod57 (talk) 00:10, 24 October 2012 (UTC)

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Is it ok to delete this above comment now ? Will do so if no objections - Rod57 (talk) 13:44, 30 January 2017 (UTC)

Should clarify if all are inhibitors of only class I PI3K

Should clarify if all are inhibitors of only class I PI3K - perhaps a section saying what is known about class II, III or IV PI3K inhibitors ? - Rod57 (talk) 13:20, 30 January 2017 (UTC)

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Duvelisib mentioned in commercial wording

The only drug mentioned as both 'notable example' as well as in "approvals" is Duvelisib. The other approved drugs are not referred to as noteworthy examples. It is also noteworthy that only for duvelisib the tradename is mentioned in the paragraph.

I don't find duvelisib to be an especially noteworthy drug, compared to the other two approved drugs. I also do think stuff like tradename should be part of the respective article for the substance (like it is fine for the other two approved drugs).

Please be aware I do have a COI and thus will not edit the article myself.

Wowbagger2 (talk) 10:09, 7 January 2019 (UTC)