Talk:Plasma protein binding
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New article hand written.
Therapeutic Index
editThe last paragraph is talking about drugs with a low therapeutic index, not high as stated incorrectly. See the link to therapeutic index for clarification. Drugs with a low therapeutic index must be monitored more carefully. —The preceding unsigned comment was added by 74.140.184.67 (talk) 23:05, 22 April 2007 (UTC).
pH of drugs binding albumin
editFair enough, albumin is basic I'll take your word on that; electrostatic charges mean that acidic drugs will bind warfarin. But I can't see that neutrally charged drugs at physiological pH will bind any more than they'd bind acidic proteins. —Preceding unsigned comment added by 90.152.14.118 (talk) 10:29, 17 September 2008 (UTC)
As far as i can tell, albumin is acidic (on every other website i have viewed) eg. [1] [2] though i can't find any defintive sources. please enlighten me if you have such a source :) Mursy (talk) 16:04, 9 October 2013 (UTC)
Warfarin % binding
editIt says here that it's 97%, but on the warfarin article, it says it's 99.5%. Which is correct? --193.128.72.68 (talk) —Preceding undated comment was added at 16:08, 29 January 2009 (UTC).
No article yet for Protein Binding ?
editI am not involved in pharmacology. I am looking at the article Lorazepam and the pharmacology section says:
... its uniqueness,[24][25] advantages and disadvantages are largely explained by its pharmacokinetic properties (poor water and lipid solubility, high protein binding and non-oxidative metabolism to a pharmacologically inactive glucuronide form)...
By protein binding, is it referring to this article? If so then a redirect should be created: protein binding -> Plasma protein binding
As a non-expert I am going to leave this to someone more knowledgable to answer and to create the redirect if necessary.
Incorrect math
editThe article says, "Higher drug concentrations would lead to a higher fraction unbound, because the plasma protein would be saturated with drug and any excess drug would be unbound." This is mostly wrong - the fraction unbound is not (heavily) dependent on the drug concentration. The fraction unbound equals 1/(1 + constant*[Protein]), and is independent of [Drug]. "Constant" depends on the affinity of that drug for plasma proteins. This is a formula I have committed to memory, but I could perhaps source it from a kinetics textbook.67.189.250.201 (talk) 07:58, 18 November 2010 (UTC)
Protein binding drug-drug interactions are probably not clinically relevant
editTo my knowledge, there has never been any good evidence of protein binding causing drug-drug interactions in a clinical setting. It is theoretically interesting, but probably not relevant.
The only clinically relevant aspect of plasma protein binding: When plasma protein concentrations fall (e.g. due to liver failure), fraction unbound rises, the volume of distribution rises, and the concentration at target tissues rises. Efficacy, toxicity, metabolism, and excretion are all increased/quickened by low plasma protein. This is most pronounced for drugs with a small volume of distribution and a high amount of plasma protein binding (which often occur together).67.189.250.201 (talk) 07:58, 18 November 2010 (UTC)
Pregnancy
editWould someone be willing to write something on the effects of pregnancy on protein binding? — Preceding unsigned comment added by 130.123.108.22 (talk) 04:01, 31 August 2013 (UTC)
Impact of the altered protein binding
editThe first sentence in this paragraph is missing a word. Please insert the relevant word. Thanks Hydra Rain (talk) 22:41, 12 March 2015 (UTC)