Talk:Polyaminopropyl biguanide

Where's the data to support this article?

When I look on PubMed, I find criticisms of its safety, e.g., it causes reduced viability of human corneal epithelial cells at very low concentration (0.0001%) within minutes, and was not deemed safe for use in spray-on personal care products at 0.3%. When used it wet wipes, it caused sensitization and contact uticaria. Although it's good as a bacteriostatic at 0.0001%, it doesn't work against encysted acanthamoebas at less than 5x that concentration, and then takes 10 hours to work. I'm left with the impression that it's useful, but that safety isn't well established. This article, by contrast, reads like an infomercial. If it stays that way much longer, I may pare out statements which have long been marked an needing a citation, which is to say, most of it. 173.228.54.186 (talk) 20:44, 10 December 2015 (UTC)

errata and/or missing data

the given CAS number is non-existant — Preceding unsigned comment added by 84.50.211.64 (talk) 13:06, 20 January 2016 (UTC)

The given CAS number is correct. The website that it links to is a database of only the most common chemicals, not a complete database of all CAS numbers. -- Ed (Edgar181) 13:08, 20 January 2016 (UTC)

tnx for correcting. another confusion is that the article refers to PHMB as in 'Purista is a PHMB-based preparation' without linking to PHMB page of telling how are they related.

Proposal for merging with PHMB article

I have been reading about this ad it seems that polyaminopropyl biguanide (PAPB) is just a synonym for polyhexamenthylene biguanide (PHMB) or polyhexanide. In fact, EU regulation statements on PHMB (see 2015 report and 2016 report) list PAPB as a synonym for PHMB that is used for cosmetic applications (PAPB is the approved INCI name for the same molecule). This can be verified by a quick search at the SpecialChem database: PHMB is used as the abbreviation for polyaminopropyl biguanide, which is listed under the same CAS number as PHMB (32289-58-0). Thus, I propose merging the polyhexamethylene biguanide and polyaminopropyl biguanide articles. Please, let me know if you have any objections. Luis Bentolila (talk) 23:11, 7 February 2020 (UTC)

I have opened a merger discussion on the destination page. Please redirect there for any comments. Luis Bentolila (talk) 00:17, 8 February 2020 (UTC)

Article is misleading. As mentioned polyaminopropyl biguanide is wrongly used for PHMB in many documents. PAPB is likely not used / registered as antimicrobial. All citations in this article refer to hexanid (PHMB) Dominik-jan (talk) 17:28, 5 May 2024 (UTC)