Talk:Post-polio syndrome

Arthur C. Clarke post-polio

Okay -- the two sources contradict themselves. One says he contracted it in 1984, the other one in 1988. Which is right? --Rhombus (talk) 07:22, 21 July 2010 (UTC)

A seriously defective article

This article is defective in many respects and needs to be rewritten from the ground up. There is now no debate as to the cause of post-polio syndrome, owing in great measure to the pioneering work of Lauro Halstead. The article cites the important contemporary work of Halstead and Silver without crediting Halstead. 12.214.52.191 (talk) 19:23, 22 August 2008 (UTC)

I totally agree with this commenter. I have neither the expertise nor WIKI ability to do it myself, somebody else would do it. When they do, they will stress that this condition is markedly similar to neurodegenerative disorders and should respond similarly. PietrH (talk) 23:50, 6 April 2010 (UTC)

Erm, upon consideration of shingles and its previous relationship with a certain pox, one may ponder the relationship with a damaged virus proliferating in the victim. Of course, one's mind may wander in ANY direction, but HERE, the topic must remain encyclopedic. For in fact, one could argue, without evidence or references for evil spirits.Wzrd1 (talk) 06:05, 16 February 2012 (UTC)

https://www.sciencedirect.com/science/article/pii/S1201971215001058 Does anyone know more about this article? It assets there are a few strands of polio that might survive in vitro. The NIH site says the long-term survival of the virus was disproven but Harvard says it is controversial. This study is from 2015; has anyone followed up or discredited it? Debdelilah (talk) 16:48, 22 August 2020 (UTC)

References

A few more references for many of the statements made would be helpful, and enable the reader to verify and clarify. Jagra (talk) 08:33, 4 April 2008 (UTC)

== I had polio at about one year of age, and it left me with a paralyzed leg and hip. I'm now fifty-six and have been experiencing post-polio for about the past twenty-five to thirty years. I can't pinpoint the exact start of post-polio because I didn't realize what was happening to me the first day I could no longer step up onto a curb. The symptoms and treatments described in this article agree with my experience with both polio and post-polio. Having been a "can do" person all my life, it's distressing to have to struggle through these last years to retirement, but I'm hanging in there.

--BestWriter (talk) 05:05, 12 September 2008 (UTC)

Rewrite

I've just completely a major rewrite of the article using much better sources for the mostpart. Some parts of the original text have been left intact but a lot of it was complete garbage. I've still got to write a little more on treatment and then I'm done for now. —Cyclonenim (talk · contribs · email) 12:33, 25 December 2008 (UTC)

Sequelae of what

This edit to the lede defined PPS as a late complication of paralytic polio, with a reliable source. A subsequent edit deleted the reference and there are claims in subsequent edit summaries that PPS can be a late complication of poliomyelitis more generally. That is a peculiar claim, given that most infections with the polio virus are gastrointestinal, not involving the central nervous system. The claim that PPS can result from any form of poliomyelitis needs a reliable source. --Una Smith (talk) 16:08, 31 October 2009 (UTC)

Here are four MEDRS (two pubmed listed reviews, one article on the subject of nonparalytic polio and PPS, and one book written by the head of the Spaulding Polio Center) that discuss the issue and state that PPS does occur in patients with NPP, mild polio, and even patients that didn't realize they had polio. Rehabilitation for postpolio sequelae PMID 15373379 full text link, Paralytic vs. "nonparalytic" polio: distinction without a difference? PMID 10678596, Late functional loss in nonparalytic polio PMID 10678598,full text link of similar article by the authors and, Post-polio syndrome: a guide for polio survivors and their families Chapter 3. Ward20 (talk) 17:55, 31 October 2009 (UTC)

Upon more thought and review of the literature, the difficulty apparently lies with the diagnosis of paralytic polio as these sources discuss that polio CNS involvement may occur with a minimum or no paralysis recognized by the patient or medical professionals. Ward20 (talk) 18:14, 31 October 2009 (UTC)

Further work

I have noted Cyclonim's work from December 2008, but I think this article could still be improved further. Many of the sources are not technically WP:MEDRS, and some sections could be added and developed (e.g. diagnostic criteria). I've already got some sources available and plan to spend the next few weeks making some changes. The following are available:

• Lancet Neurol 2010 doi:10.1016/S1474-4422(10)70095-8
• Muscle Nerve 2005 doi:10.1002/mus.20259
• EFNS guideline 2006 doi:10.1111/j.1468-1331.2006.01385.x
• PPS and anesthesia Anesthesiology 2005 doi:10.1097/00000542-200509000-00029

Help will be appreciated. JFW | T@lk 19:54, 19 August 2010 (UTC)

The sections with work needed:

• Introduction
• Signs and symptoms - needs separating in symptom groups with an attempt to link them to the disease process
• Causes - this should probably go and be absorbed into the "mechanism" section
• Diagnosis - needs discussion of the criteria and differential diagnosis, as well as typical NCS/EMG and imaging appearances
• Management - should be renamed treatment, a term that people understand
• Prognosis - could do with tightening
• Epidemiology - could do with tightening
• History - needs writing

Let's see. JFW | T@lk 20:37, 19 August 2010 (UTC)

Cochrane

doi: 10.1002/14651858.CD007818.pub3 JFW | T@lk 14:27, 10 November 2015 (UTC)

Survival in vitro

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005114 Have any follow ups been done since 2015 on survival of the poliovirus long term in some infected individuals? Debdelilah (talk) 17:34, 22 August 2020 (UTC)

Prognosis Section

The Prognosis section begins by mentioning that PPS is generally not lethal, and then goes on to say that it has a mortality rate of 25%! Right after stating the mortality rate, once again the reader is told that PPS is "otherwise" not lethal. Am I missing something, or is the mortality rate downplayed in this section? I believe this section needs to be edited to more accurately represent the mortality rate of 25%.MarkParker1221 (talk) 03:23, 29 January 2024 (UTC)