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I believe that when someone says 'a pox on him' the meaning is the same as the disease - it's just expressing the hope that he will get a serious disease. DJ Clayworth 15:29, 14 Oct 2003 (UTC)

It can mean both according to http://www.m-w.com

Cowpox

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There does not seem to be any entry about cowpox.

POX software tool

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Also missing an entry for the POX software tool for OpenFlow.