Talk:RBBP4

Sources of RBBP4

Does anyone have anything on sources for RBBP4? Prof Scott Small at Columbia University has said that physical exercise, dietary supplements or pharmaceuticals could possibly be used to increase RbAp48 in the hippocampus of the human brain. JCJC777JCJC777 (talk) 20:41, 2 September 2013 (UTC)

References

The key word here is possibly. Currently there are no known sources of RBBP4. RBBP4 is not like a vitamin or food supplement that one can ingest to increase its levels. RBBP4 is a protein and if ingested, would be broken down in the digestive track just like any other protein. Increasing the levels of an intracellular protein found in the brain would be extremely difficult. Perhaps a way could be found to decrease the rate of its break down and thereby increase its steady state levels, but no one including Scott Small has a clear idea how this could be accomplished. Boghog (talk) 00:32, 3 September 2013 (UTC)

Now after reading the original paper (PMID 23986399), I notice that the authors themselves mention a possible therapeutic strategy. RBBP4 works at least in part through the PKA-CREB1-CPB pathway. The author have previously shown (PMID 10220457) that dopamine D1/D5 agonists such as 6-Br-APB and SKF-38,393 that are positively coupled to adenylyl cyclase and the cAMP phosphodieserase inhibitor rolipram reduce meomory defects in aged mice. Boghog (talk) 14:33, 6 September 2013 (UTC)

One additional note. The authors (PMID 23986399) used lentiviral gene transfer to increase the expression of RbAp48 in older mice. I have edited the text to add more details about the RbAp48 experiments including the gene transfer results. Please note that lentivirus gene transfer has only been used experimentally and has not been approved for human use. Please also note that the lentivirus was injected directly into the brains of older mice. Even if it were an approved treatment, I am not sure too many people would agree to this type of therapy ;-) Boghog (talk) 07:39, 8 September 2013 (UTC)