Talk:Radiation-induced lung injury/Archive 1

Source list, to be worked in

Please feel free to add or cross off the list:

• General overviews:
  • Lung toxicity following chest irradiation in patients with lung cancer. PMID 11804681.
  • Radiation effects in the lung. PMID 3549278.
  • Injury to the lung from cancer therapy: clinical syndromes, measurable endpoints, and potential scoring systems. PMID 7713782.
  • Radiation and the lung: a reevaluation of the mechanisms mediating pulmonary injury. PMID 7836090.
• Pathophysiology:
  • Link to our articles on biological effects of ionizing radiation in general
  • Role of oxygen free radicals and superoxide dismutase? Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. PMID 9578839. Mouse study, >10 years old, ? anything more recent?
  • Cytokines: probably a whole separate topic, ? too much detail. Maybe focus on TGF-beta as the most studied cytokine in radiation injury: PMID 9719112, mention prospective clinical trials incorporating TGF-beta: PMID 12829134, PMID 16979900, PMID 17905467.
  • Early vs. late effects (inflammation vs. fibrosis, need to find refs)
  • ? mention bilateral hypersensitivity phenomenon, or too obscure? PMID 10362031.
• Etiology/Risk factors:
  • Susceptibility: Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. PMID 18006824.
  • Volume of lung irradiated, total dose of radiation, fractionation, concurrent chemo as risk factors (find refs).
  • Predictive models: PMID 17921108, PMID 17926943.
• Signs/symptoms
• Diagnosis
• Treatment/prognosis
• History?

Feel free to add or cross off - this is intended as a starting point to develop the article. MastCell ^Talk 18:55, 20 May 2009 (UTC)

• Link in article to "pulmonary insufficiency" incorrectly redirects the reader to "pulmonary valve insufficiency." —Preceding unsigned comment added by 71.102.135.35 (talk) 21:17, 9 January 2011 (UTC)