Talk:Radiation-induced lung injury/Archive 1

Source list, to be worked in

edit

Please feel free to add or cross off the list:

  • General overviews:
    • Lung toxicity following chest irradiation in patients with lung cancer. PMID 11804681.
    • Radiation effects in the lung. PMID 3549278.
    • Injury to the lung from cancer therapy: clinical syndromes, measurable endpoints, and potential scoring systems. PMID 7713782.
    • Radiation and the lung: a reevaluation of the mechanisms mediating pulmonary injury. PMID 7836090.
  • Pathophysiology:
    • Link to our articles on biological effects of ionizing radiation in general
    • Role of oxygen free radicals and superoxide dismutase? Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. PMID 9578839. Mouse study, >10 years old, ? anything more recent?
    • Cytokines: probably a whole separate topic, ? too much detail. Maybe focus on TGF-beta as the most studied cytokine in radiation injury: PMID 9719112, mention prospective clinical trials incorporating TGF-beta: PMID 12829134, PMID 16979900, PMID 17905467.
    • Early vs. late effects (inflammation vs. fibrosis, need to find refs)
    • ? mention bilateral hypersensitivity phenomenon, or too obscure? PMID 10362031.
  • Etiology/Risk factors:
    • Susceptibility: Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. PMID 18006824.
    • Volume of lung irradiated, total dose of radiation, fractionation, concurrent chemo as risk factors (find refs).
    • Predictive models: PMID 17921108, PMID 17926943.
  • Signs/symptoms
  • Diagnosis
  • Treatment/prognosis
  • History?

Feel free to add or cross off - this is intended as a starting point to develop the article. MastCell Talk 18:55, 20 May 2009 (UTC)Reply