Talk:Reference genome

A fact from Reference genome appeared on Wikipedia's Main Page in the Did you know column on 22 June 2010 (check views). The text of the entry was as follows:

Did you know... that the current human reference genome (pictured) is a mosaic of DNA sequences from thirteen volunteers recruited in Buffalo, New York?

A record of the entry may be seen at Wikipedia:Recent additions/2010/June.

Wikipedia

Molecular Biology: Genetics / MCB / COMPBIO

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Genetics task force (assessed as Mid-importance).
	This article is supported by the Molecular and Cell Biology task force (assessed as Low-importance).
	This article is supported by the Computational Biology task force (assessed as Low-importance).

Untitled

Latest comment: 2 years ago5 comments4 people in discussion

Add table of human genome releases from here? https://genome.ucsc.edu/FAQ/FAQreleases.html#release1 Hdash (talk) 12:11, 30 July 2014 (UTC)Reply

Have started this table. Jmc200 (talk) 14:01, 18 August 2016 (UTC)Reply

I would like to know how the transition from NCBI to GRC happened, but I'm struggling to find any good sources on this. Jmc200 (talk) 12:54, 23 August 2016 (UTC)Reply

Where is the claim about "GRCh38 in 2017.[15] This build only has 120 gaps" from? I could only find the reference about GRCh37 having 250 gaps.

Meanwhile, GRCh38.p14 is out, and the claim about GRCh39 indefinitely postponed is gone. — Preceding unsigned comment added by Mltam (talk • contribs) 23:15, 18 August 2022 (UTC)Reply

Hi Mltam,

About the first claim "GRCh38 in 2017.[15] This build only has 120 gaps". After reading the reference more carefully, it looks like an misunderstanding. In the reference 15, the table 1, there's a comparison between GRCh37 and GRCh38 and that number doesn't appear at all, but in the reference [18], the table 1, which is a comparison GRCh38 vs T2T-CHM13v1.1, it does shows that GRCh38 has 120.31 gap Mbp (not 120 individual gaps). So, i'll try to fix it.

About GRCh39. Yes, it may be that there's no demand for its release now that GRCh38.p14 has been published, but currently GRCh39 is still expected to release in the near future. So, I think it is important to, at least, mention it. Aarón Mayo (talk) 10:43, 19 August 2022 (UTC)Reply

Expansion of the article

Latest comment: 2 years ago1 comment1 person in discussion

Hi,

I've been adding content to the article, which, I believe, has greatly improved since its state in May (Reference genome - Wikipedia) and I just wanted to invite anyone interested to edit any new content if they consider it necessary and to expand the rest of the article. I see three topics with expansion potential: "Properties of reference genomes", where we could talk about contigs and scaffolds and how they are constructed, and gap types (scaffold nonbreaking gaps between contigs and scaffold breaking gaps); "Mouse reference genome", where the structure of the "human reference genome" section could be replicated, adding a little of history of its assemblies and patches; "Other genomes", where we could talk about some specific model organism and its reference genome.

Regarding, Aarón Mayo (talk) 08:08, 21 August 2022 (UTC)Reply

Add topic