Talk:Selenium and Vitamin E Cancer Prevention Trial
Latest comment: 4 years ago by Ee1518 in topic Speculation why Selenium didn't help
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Speculation why Selenium didn't help
edithttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022975/ Published online 2010: SELECT was a phase III randomized, placebo-controlled trial of selenium (200 μg/d from L-selenomethionine), vitamin E (400 IU/d of α-tocopheryl acetate) or both. Possible reasons Selenium didn't work:
- The use of L-selenomethionine rather than high-selenium brewer’s yeast was influenced by logistic factors. L-selenomethionine is only one of >20 selenium-containing species in brewer’s yeast.
- The NPC study participants who clearly benefited from selenium administration had lower baseline selenium levels, but the relevance of this finding to SELECT is unclear.
- Too large daily dose of Selenium. Much over daily requirement.
More about Selenium & Health: https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/#h7 This section focuses on four diseases and disorders in which selenium might play a role: cancer, cardiovascular disease, cognitive decline, and thyroid disease.