Talk:Sodium thiopental

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How exactly are the names and ages of victims of the convicts executed with sodium thiopental relevant to the drug itself? 91.62.14.47 (talk) 20:09, 29 September 2010 (UTC)

Reworded the part about Ohio and capital punishment to fit the current situation more appropriately. -chris- —Preceding unsigned comment added by 158.104.7.155 (talk) 18:17, 8 December 2009 (UTC)

I have deleted the second reference - it was a link to some Dutch kid's birthday page. Not appropriate for a page on Sodium Pentathol.

How can one tell?

How can one tell if he was submitted to pentathol i.e. while he was committed and given shots of antipsychotics. I have memory blanks and other difficult symptoms that are not on adverse list for neither Risperdal nor Haloperidol?

Thanks -- Mtodorov 69 13:14, 10 May 2006 (UTC)

Barbituate, or Benzo?

"Barbiturates, with the exception of intravenous diazepam, do not have analgesic effects."

I would assume that diazepam is a bezodiazepam and not a barbituate, no matter how it is administered?

Doh, wow... my mistake. I was writing on barbiturates so much... Thanks. ER MD 05:03, 20 June 2006 (UTC)

Speaking of that line, It says they have anaesthetic effects, but not analgesic effects. What's the difference?

An-algesic - means 'no algesia', no pain.

An-aesthetic - means 'no aesthetic', no awareness.

You can be under an anaesthetic but without being given an analgesic, the body will still respond as if it is in pain (ie increase heart rate, increase blood pressure, release adrenaline etc). —Preceding unsigned comment added by 165.118.1.50 (talk) 00:24, 7 January 2008 (UTC)

Half life and zero order elimination kinetics

If sodium thiopental is eliminated according to zero order kinetics, I would say it is not appropriate to refer to a half life (under 'medically induced coma'). According to zero order kinetics, the amount of time required to reduce the blood concentration by one half is a function of the amount initially present.

Asteen 19:05, 12 March 2007 (UTC)

1. Thiopental is eliminated according to zero order kinetics at higher doses. It is eliminated via 1st order kinetics at lower doses.

2. I agree, elimination half-life is not appropriate. Thiopental is not used by infusion becuase of it's Context Sensitive Half Time (CSHT). ie. The longer the infusion continues (time = context), the more drug deposited in preipheral tissues. When the infusion is stopped, the drug re-distributes to the plasma, continuing the effect (they take a much longer time to wake up). This is added to the Zero Order Clearance at high doses (CSHT takes this into account).

3. Zero Order Kinetics: Clearance is independent of concentration of drug. First Order Kinetics: Clearance is dependent on concnetration of drug. —Preceding unsigned comment added by 165.118.1.50 (talk) 00:22, 7 January 2008 (UTC)

NPOV

The use of the term "retentionist" may violate WP:NPOV. Unimath (talk) 05:35, 26 March 2009 (UTC)

Truth serum

I have modified the word "lie" to "relate a false story". It is a lie, of course, to relate a falsehood in knowledge of its falsehood. To state a falsehood that one believes true is not itself a lie. Such is possible if one one is brainwashed or has faulty knowledge. --Pbrower2a (talk) 20:57, 8 December 2009 (UTC)

note on my slight changes

i have been having pentathol the last two weeks, and several anesthesiologists have told me the reported sensation is a taste of garlic, and in truth it is likely one of the two sensations, and neither is experienced universally.--24.150.153.160 (talk) 05:38, 8 January 2010 (UTC)

Reference link 11 is defect

--88.66.250.250 (talk) 01:05, 17 January 2010 (UTC)

Fixed. Fortunately WebCite has the page archived. Svick (talk) 01:41, 17 January 2010 (UTC)

Routes: oral

It's mentioned but the text doesn't contain the doses and their effects when someone eats it.--79.121.56.99 (talk) 12:07, 24 June 2010 (UTC)

"Fact" not mentioned in the cited article?

In §2.4, it is stated:

Executions using the three-drug combination are usually effective in approximately 10 minutes, but have been known to take several times this amount of time. The use of thiopental alone is hypothesized to cause death in approximately 45 minutes.

The following article is cited as its authority:

http://www.breitbart.com/article.php?id=D9CF8Q2G6&show_article=1&catnum=0

Maybe it's just me, but I read the cited article and don't see any statement of the sort. The only mention of execution time (as opposed to preparation time) is:

The actual execution appeared to last just 10 minutes

No mention of "hypothesizing", no mention of "but have been known to take several times...". Anyone see it differently? Did I miss something?

Not to be picky but I really dislike inaccurate quotes. — UncleBubba ^{( T @ C )} 00:14, 12 February 2011 (UTC)

Update Request

The most recent execution in Ohio in now Frank Spisak. Please update page109.253.183.58 (talk) 21:37, 17 February 2011 (UTC)

Update it yourself! That's the Wiki way! — UncleBubba ^{( T @ C )} 00:22, 18 February 2011 (UTC)

Anesthesia section

In "Anesthesia" section: "...but it will be sometime before it is entirely removed (metabolised) from their bodies."

The time for removal is missing in the sentence. --EJF — Preceding unsigned comment added by 216.99.185.50 (talk) 12:49, 16 January 2015 (UTC)

I agree and have marked it with the {{vague}} tag. -- Ed (Edgar181) 13:23, 16 January 2015 (UTC)

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Controversy section - FDA warning issued to Hospira

The controversy section starts with an explanation and a September 2010 quote from Hospira regarding Sodium thiopental being unavailable for capital punishment. A reading of that gives the impression that Hospira withdrew sodium thiopental from the market due to moral objections over its use.

A reading of the following article suggests that the above may not have been Hospira's motive: http://www.theatlantic.com/magazine/archive/2015/06/execution-clayton-lockett/392069/

Everything currently listed in the Controversy section appears to be accurate - I propose that we add a section with additional information from The Atlantic's article that is relevant to sodium thiopental. Perhaps the following along with a new reference link:

In April 2010, the Food and Drug Administration sent a warning letter to Hospira after discovering that some of the drugs manufactured at its pharmaceutical plant in Rocky Mount, NC were contaminated. Hospira responded by stopping manufacture of sodium thopental. No other company in the U.S. was approved by the FDA to make sodium thiopental. — Preceding unsigned comment added by NewFrzr (talk • contribs) 05:55, 23 May 2016 (UTC)

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Shouldn't this article be called just "Thiopental"?

WP:PHARMMOS states we should use the INN for the name of drug articles like this one, which does not include the salt name, just the active moiety name which in this case is thiopental. Is there a reason why this article doesn't follow the INN? Is it due to how common the name "sodium thiopental" is vs. the INN "thiopental" or is it just an oversight? Fuse809 (contribs · email · talk · uploads) 09:28, 20 August 2017 (UTC)

deprograming

Pentothol can be used to hypnotize and deprogram people from religion for one and other possible areas of use to modify behavior in a person for a life time. — Preceding unsigned comment added by 2601:602:9A01:5E70:8010:B3BD:48DE:2C7 (talk) 17:30, 28 September 2018 (UTC)