Talk:Spliceosome
Latest comment: 4 years ago by Rich Farmbrough in topic Type II introns
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Spliceome listed on Wikipedia:Votes for deletion Feb 20 to Feb 26 2004, redirected to Spliceosome.
Untitled
editDiscussion pasted from vfd:
- Spliceome - a freshly invented term, as far a I can tell. (44 google hits, of which most are misspellings of spliceosome or about a database named SpliceOme) Stewart Adcock 22:34, 20 Feb 2004 (UTC)
- I have heard it used in the bioinformatics literature. I suggest that spliceome redirect to spliceosome, and incorporate that material into a new section in spliceosome. --Lexor|Talk 23:41, 20 Feb 2004 (UTC)
-- Graham :) 21:05, 26 Feb 2004 (UTC)
- My guess is, that spliceOme (like genOme/transcriptOme/proteOme...) is a collection of all splicing variants of all pre-mRNAs & mRNAs, and maybe even some other RNAs which are modified by the splicing reactions (like tRNA editing?). Kazkaskazkasako (talk) 11:13, 30 July 2009 (UTC)
LSm
editThe article lacks everything included in the LSm article. Who dares the courageous merge? --Ayacop (talk) 18:43, 13 April 2009 (UTC)
Type II introns
editI have removed the following:
In 2008 new evidence derived from the first crystal structure of a group II intron suggested that the spliceosome is actually a ribozyme, and that it uses a two–metal ion mechanism for catalysis.[1]
- ^ Toor N, Keating KS, Taylor SD, Pyle AM (April 2008). "Crystal structure of a self-spliced group II intron". Science. 320 (5872): 77–82. Bibcode:2008Sci...320...77T. doi:10.1126/science.1153803. PMC 4406475. PMID 18388288.
- The intron in question is self-splicing, and may not comprise the spliceosome in its entirety.
- Its not clear if the reverse transcriptase ORF is considered part of the ribozyme or not. (The ORF was replaced for the crystallisation, so is not discussed in the paper.)
- The importance of this paragraph is in the evolutionary development of the spliceosome, so should be part of a progression in that context.
All the best: Rich Farmbrough, 20:40, 29 December 2019 (UTC).